rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2013-9-3-311-315rpcardio-10Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИCLINICAL SIGNIFICANCE OF DRUGINDUCED INTERVALS QT AND QTC PROLONGATIONКЛИНИЧЕСКОЕ ЗНАЧЕНИЕ УДЛИНЕНИЯ ИНТЕРВАЛОВ QT И QTC НА ФОНЕ ПРИЁМА ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВФурманН. В.FurmanN. V.

Кандидат медицинских наук,  зав. лабораторией неотложной кардиологии

furman.nikolay@gmail.comШматоваС. С.ShmatovaS. S.

Кандидат медицинских наук, младший научный сотрудник лаборатории неотложной кардиологии

furman.nikolay@gmail.comСаратовский научно-исследовательский институт кардиологии, СаратовРоссияSaratov Research Institute of Cardiology, SaratovRussian Federation20131809201593311315Copyright © Furman N.V., Shmatova S.S., 20152015Фурман Н.В., Шматова С.С.Furman N.V., Shmatova S.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/10

Interval QT prolongation is a predictor of the life-threatening cardiac arrhythmias — polymorphic ventricular tachycardia (torsade de pointes). Long QT syndrome may be congenital or acquired. It is known that a wide range of both antiarrhythmic and non-cardiac medications might lead to QT interval prolongation. List of drugs that cause QT prolongation is constantly growing and being updated. The review contains current data on the clinical significance of the control of QT interval duration within drug therapy. Clinical conditions associated with an increased risk of QT interval prolongation are described. Drugs that can induce QT prolongation are also discussed.

Увеличение длительности интервала QT является предиктором развития жизнеугрожающего нарушения ритма сердца — желудочковой тахикардии типа «пируэт» (torsade de pointes). Наряду с врождённым, существует и приобретённый синдром удлиненного интервала QT. Известно много лекарственных препаратов, как антиаритмических, так и «некардиальных», которые могут привести к удлинению интервала QT. Список препаратов, вызывающих удлинение интервала QT, постоянно увеличивается и обновляется. В обзоре содержатся современные данные о клиническом значении контроля длительности интервала QT на фоне медикаментозной терапии, приведены примеры состояний, сопровождающихся повышенным риском удлинения интервала QT и, следовательно,  развития желудочковой тахикардии типа «пируэт», а также представлен перечень лекарственных препаратов, потенциально могущих привести к увеличению длительности интервала QT.

синдром удлиненного интервала QTжелудочковая тахикардия типа «пируэт»torsade de pointesжизнеугрожающая аритмияlong QT syndromepolymorphic ventricular tachycardiatorsade de pointeslife-threatening arrhythmiasReferencesRautaharju P.M., Surawicz B., Gettes L.S. AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram Part IV: The ST Segment, T and U Waves, and the QT Interval A Scientific Statement From the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Circulation 2009;119:e241–e250Rautaharju P.M., Surawicz B., Gettes L.S. AHA/ACCF/HRS Recommendations for the Standardization and Interpretation of the Electrocardiogram Part IV: The ST Segment, T and U Waves, and the QT Interval A Scientific Statement From the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Circulation 2009;119:e241–e250Al-Khatib S.M., LaPointe N.M.K., Kramer J.M. What clinicians should know about the QT interval. JAMA2003;289(4): 2120–7.Al-Khatib S.M., LaPointe N.M.K., Kramer J.M. What clinicians should know about the QT interval. JAMA2003;289(4): 2120–7.Hannibal G.B. Hasanien A.A., Pickham D. ECG Challenges: Measurement and Rate Correction of the QT Interval. AACN Advanced Critical Care 2013;24(1):90–6.Hannibal G.B. Hasanien A.A., Pickham D. ECG Challenges: Measurement and Rate Correction of the QT Interval. AACN Advanced Critical Care 2013;24(1):90–6.Algra A., Tijssen J.G., Roelandt J.R. et al QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest. Circulation 1991;83:1888–94.Algra A., Tijssen J.G., Roelandt J.R. et al QTc prolongation measured by standard 12-lead electrocardiography is an independent risk factor for sudden death due to cardiac arrest. Circulation 1991;83:1888–94.Straus S.M., Kors J.A., De Bruin M.L. et al Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol 2006;47:362–7.Straus S.M., Kors J.A., De Bruin M.L. et al Prolonged QTc interval and risk of sudden cardiac death in a population of older adults. J Am Coll Cardiol 2006;47:362–7.Chugh S.S., Reinier K., Singh T. Determinants of Prolonged QT Interval and Their Contribution to Sudden Death Risk in Coronary Artery Disease The Oregon Sudden Unexpected Death Study. Circulation 2009;119:663–70.Chugh S.S., Reinier K., Singh T. Determinants of Prolonged QT Interval and Their Contribution to Sudden Death Risk in Coronary Artery Disease The Oregon Sudden Unexpected Death Study. Circulation 2009;119:663–70.van Noord C., Eijgelsheim M., Stricker B.H.Ch. Drug- and non-drug-associated QT interval prolongation. British Journal of Clinical Pharmacology 2010;70 (1):16–23.van Noord C., Eijgelsheim M., Stricker B.H.Ch. Drug- and non-drug-associated QT interval prolongation. British Journal of Clinical Pharmacology 2010;70 (1):16–23.Liew R. Electrocardiogram-Based Predictors of Sudden Cardiac Death in Patients With Coronary Artery Disease. Clin. Cardiol. 2011;34(8):466–73.Liew R. Electrocardiogram-Based Predictors of Sudden Cardiac Death in Patients With Coronary Artery Disease. Clin. Cardiol. 2011;34(8):466–73.Zhang Y., Post W.S., Blasco-Colmenares E. et al Electrocardiographic QT interval and mortality: a metaanalysis. Epidemiology 2011;22(5):660–70.Zhang Y., Post W.S., Blasco-Colmenares E. et al Electrocardiographic QT interval and mortality: a metaanalysis. Epidemiology 2011;22(5):660–70.Zhang Y., Post W.S., Dalal D. et al QT-Interval Duration and Mortality Rate. Results From the Third National Health and Nutrition Examination Survey. Arch Intern Med 2011;171(19):1727–33.Zhang Y., Post W.S., Dalal D. et al QT-Interval Duration and Mortality Rate. Results From the Third National Health and Nutrition Examination Survey. Arch Intern Med 2011;171(19):1727–33.Williams E.S.В., Thomas K.L.В., Broderick S.В. et al. Race and gender variation in the QT interval and its association with mortality in patients with coronary artery disease: Results from the Duke Data- bank for Cardiovascular Disease (DDCD). Am Heart J 2012;164(3):434–41.Williams E.S.В., Thomas K.L.В., Broderick S.В. et al. Race and gender variation in the QT interval and its association with mortality in patients with coronary artery disease: Results from the Duke Data- bank for Cardiovascular Disease (DDCD). Am Heart J 2012;164(3):434–41.Sauer A.J., Newton-Cheh C. Clinical and Genetic Determinants of Torsade de Pointes Risk Circulation 2012;125:1684–94.Sauer A.J., Newton-Cheh C. Clinical and Genetic Determinants of Torsade de Pointes Risk Circulation 2012;125:1684–94.Yan G.X., Lankipalli R.S., Burke J.F. et al Ventricular repolarization components on the electrocardiogram. Cellular basis and clinical significance. J Am Coll Cardiol 2001;42:401–9.Yan G.X., Lankipalli R.S., Burke J.F. et al Ventricular repolarization components on the electrocardiogram. Cellular basis and clinical significance. J Am Coll Cardiol 2001;42:401–9.Zareba W., Moss A.J., La Cessie S. Dispersion of ventricular repolarization and arrhythmic cardiac death in coronary artery disease. Am J Cardiol 1994;74:550–3.Zareba W., Moss A.J., La Cessie S. Dispersion of ventricular repolarization and arrhythmic cardiac death in coronary artery disease. Am J Cardiol 1994;74:550–3.Doschitsin VL. Clinical analysis of electrocardiograms. Moscow: Medicine; 1982. Russian (Дощицин В.Л. Клинический анализ электрокардиограммы. М: Медицина, 1982).Doschitsin VL. Clinical analysis of electrocardiograms. Moscow: Medicine; 1982. Russian (Дощицин В.Л. Клинический анализ электрокардиограммы. М: Медицина, 1982).Sagie A., Larson M.G., Goldberg R.J. et al An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study). Am J Cardiol 1992;70:797–801.Sagie A., Larson M.G., Goldberg R.J. et al An improved method for adjusting the QT interval for heart rate (the Framingham Heart Study). Am J Cardiol 1992;70:797–801.Fridericia L.S. The duration of systole in an electrocardiogram in normal humans and in patients with heart disease. Ann Noninvasive Electrocardiol 2003;8:343–51.Fridericia L.S. The duration of systole in an electrocardiogram in normal humans and in patients with heart disease. Ann Noninvasive Electrocardiol 2003;8:343–51.Meier P., Gloekler1 S., de Marchi S.F. An indicator of sudden cardiac death during brief coronary occlusion: electrocardiogram QT time and the role of collaterals. Eur Heart J 2010; 31:1197–204.Meier P., Gloekler1 S., de Marchi S.F. An indicator of sudden cardiac death during brief coronary occlusion: electrocardiogram QT time and the role of collaterals. Eur Heart J 2010; 31:1197–204.Nachimuthu S., Assar M. D., Schussler J.M. Drug-induced QT Interval Prolongation Mechanisms and Clinical Management. Ther Adv Drug Safe 2012;5(3):241–53.Nachimuthu S., Assar M. D., Schussler J.M. Drug-induced QT Interval Prolongation Mechanisms and Clinical Management. Ther Adv Drug Safe 2012;5(3):241–53.Makarov L.M., Chuprova S.N., Kiseleva I.I. Comparison of methods for measuring the QT interval and their clinical significance. Cardiology 2004;(5):71–3. Russian (Макаров Л.М., Чупрова С.Н., Киселева И.И. Сравнение способов измерения интервала Q–T и их клиническое значение. Кардиология 2004;(5):71–73)Makarov L.M., Chuprova S.N., Kiseleva I.I. Comparison of methods for measuring the QT interval and their clinical significance. Cardiology 2004;(5):71–3. Russian (Макаров Л.М., Чупрова С.Н., Киселева И.И. Сравнение способов измерения интервала Q–T и их клиническое значение. Кардиология 2004;(5):71–73)Chan A., Isbister G., Kirkpatrick C., Dufful S. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM 2007;100:609–15.Chan A., Isbister G., Kirkpatrick C., Dufful S. Drug-induced QT prolongation and torsades de pointes: evaluation of a QT nomogram. QJM 2007;100:609–15.Higham P.D., Furniss S.S., Campbell R.W.F. Q–T dispersion and components of the Q–T interval in ischemia and infarction. Br Heart J 1995;73:32–6.Higham P.D., Furniss S.S., Campbell R.W.F. Q–T dispersion and components of the Q–T interval in ischemia and infarction. Br Heart J 1995;73:32–6.Moss A.J. Measurement of the Q–T interval and the risk associated with Q–Tc interval prolongation: a review. Am J Cardiol 1993;72:23B–25B.Moss A.J. Measurement of the Q–T interval and the risk associated with Q–Tc interval prolongation: a review. Am J Cardiol 1993;72:23B–25B.Makarov L.M. Features of the dynamics and the measurement of the QT interval in Holter monitoring. Cardiology 2002;(1):98–102. Russian (Макаров Л.М. Особенности динамики и измерения интервала Q–T при холтеровском мониторировании. Кардиология 2002;(1):98–102)Makarov L.M. Features of the dynamics and the measurement of the QT interval in Holter monitoring. Cardiology 2002;(1):98–102. Russian (Макаров Л.М. Особенности динамики и измерения интервала Q–T при холтеровском мониторировании. Кардиология 2002;(1):98–102)Merri M., Moss A., Benhorin J. et al. Relation between ventricular repolarisation duration and cardiac cycle length during 24-hour Holter recordings: findings in normal patients and patients with long QT syndrome. Circulation 1992;84:1816–21.Merri M., Moss A., Benhorin J. et al. Relation between ventricular repolarisation duration and cardiac cycle length during 24-hour Holter recordings: findings in normal patients and patients with long QT syndrome. Circulation 1992;84:1816–21.Panikkath R., Reinier K., Uy-Evanado A. Prolonged Tpeak-to-Tend Interval on the Resting ECG Is Associated With Increased Risk of Sudden Cardiac Death. Circ Arrhythm Electrophysiol 2011;4:441– 7.Panikkath R., Reinier K., Uy-Evanado A. Prolonged Tpeak-to-Tend Interval on the Resting ECG Is Associated With Increased Risk of Sudden Cardiac Death. Circ Arrhythm Electrophysiol 2011;4:441– 7.Kuszakowski M.S. Cardiac arrhythmias. St. Petersburg: IKF Foliant; 1998. Russian (Кушаковский М.С. Аритмии сердца. СПб.: ИКФ Фолиант; 1998).Kuszakowski M.S. Cardiac arrhythmias. St. Petersburg: IKF Foliant; 1998. Russian (Кушаковский М.С. Аритмии сердца. СПб.: ИКФ Фолиант; 1998).Shkol'nikova M.A., editor. Long QT interval syndrome. Moscow: Medpractika; 2001. Russian (Школьникова М.А., редактор. Синдром удлиненного интервала Q–T. М.:Медпрактика; 2001).Shkol'nikova M.A., editor. Long QT interval syndrome. Moscow: Medpractika; 2001. Russian (Школьникова М.А., редактор. Синдром удлиненного интервала Q–T. М.:Медпрактика; 2001).Vatutin N.T., Sklyanov E.V., Gritsenko P.V. Long QT syndrome. Cardiology 2002;(9):83–9. Russian (Ватутин Н.Т., Склянная Е.В., Гриценко П.В. Синдром удлиненного интервала QT. Кардиология 2002;(9):83–9).Vatutin N.T., Sklyanov E.V., Gritsenko P.V. Long QT syndrome. Cardiology 2002;(9):83–9. Russian (Ватутин Н.Т., Склянная Е.В., Гриценко П.В. Синдром удлиненного интервала QT. Кардиология 2002;(9):83–9).Antzelevitch C. Cellular basis for the repolarization waves of the ECG. Ann N Y Acad Sci 2006;1080:268–81.Antzelevitch C. Cellular basis for the repolarization waves of the ECG. Ann N Y Acad Sci 2006;1080:268–81.Butaev T.D., Treshkur T.V., Ovechkin M.A. et al. Congenital and acquired long QT syndrome. St. Petersburg: INKART; 2002. Russian (Бутаев Т.Д,. Трешкур Т.В. Овечкина М.А. и др. Врожденный и приобретенный синдром удлиненного интервала QT. СПб.: ИНКАРТ; 2002).Butaev T.D., Treshkur T.V., Ovechkin M.A. et al. Congenital and acquired long QT syndrome. St. Petersburg: INKART; 2002. Russian (Бутаев Т.Д,. Трешкур Т.В. Овечкина М.А. и др. Врожденный и приобретенный синдром удлиненного интервала QT. СПб.: ИНКАРТ; 2002).Behr E.R., Roden D. Drug-induced arrhythmia: pharmacogenomic prescribing? Eur Heart J 2013;34:89–95.Behr E.R., Roden D. Drug-induced arrhythmia: pharmacogenomic prescribing? Eur Heart J 2013;34:89–95.Boqueria L.A., Boqueria O.L., Glushko L.A. Mechanisms of cardiac arrhythmias. Annals arrhythmology 2010;(3):69–79. Russian (Бокерия Л. А., Бокерия О. Л., Глушко Л. А. Механизмы нарушений ритма сердца. Анналы аритмологии 2010;(3):69–79).Boqueria L.A., Boqueria O.L., Glushko L.A. Mechanisms of cardiac arrhythmias. Annals arrhythmology 2010;(3):69–79. Russian (Бокерия Л. А., Бокерия О. Л., Глушко Л. А. Механизмы нарушений ритма сердца. Анналы аритмологии 2010;(3):69–79).Heist E.K., Ruskin J.N. Drug-Induced Arrhythmia. Circulation 2010;122:1426–35.Heist E.K., Ruskin J.N. Drug-Induced Arrhythmia. Circulation 2010;122:1426–35.Goldenberg I., Moss A.J. Long QT Syndrome. J Am Coll Cardiol 2008;51:2291–300.Goldenberg I., Moss A.J. Long QT Syndrome. J Am Coll Cardiol 2008;51:2291–300.Kulik V.L., Yabluchansky N.I. The QT interval in the cardiac clinic. Bulletin of Kharkov National University. 2009; 879(18):73–96. Russian (Кулик В.Л., Яблучанский Н.И. Интервал QT в кардиологической клинике. Вісн Харк нац ун-ту 2009;879 (18):73–96).Kulik V.L., Yabluchansky N.I. The QT interval in the cardiac clinic. Bulletin of Kharkov National University. 2009; 879(18):73–96. Russian (Кулик В.Л., Яблучанский Н.И. Интервал QT в кардиологической клинике. Вісн Харк нац ун-ту 2009;879 (18):73–96).Kannankeril P., Roden D. M., Darbar D. Drug-Induced Long QT Syndrome. Pharmacol Rev 2010;62(4):760–81.Kannankeril P., Roden D. M., Darbar D. Drug-Induced Long QT Syndrome. Pharmacol Rev 2010;62(4):760–81.Doschitsin V.L., Segal E.S., Sedov V.V. ECG QT interval prolongation: classification, clinical significance. Cardiology 1981;(10):22–8. Russian (Дощицин В.Л., Сигал Е.С., Седов В.В. Удлинение интервала Q–T ЭКГ: классификация, клиническое значение. Кардиология 1981;(10):22–8).Doschitsin V.L., Segal E.S., Sedov V.V. ECG QT interval prolongation: classification, clinical significance. Cardiology 1981;(10):22–8. Russian (Дощицин В.Л., Сигал Е.С., Седов В.В. Удлинение интервала Q–T ЭКГ: классификация, клиническое значение. Кардиология 1981;(10):22–8).Yiyi Z., Wendy S.P., Darshan D. et al. Coffee, alcohol, smoking, physical activity and QT interval duration: results from the Third national health and nutritional examination survey. PLoS One 2011;6(2):e17584.Yiyi Z., Wendy S.P., Darshan D. et al. Coffee, alcohol, smoking, physical activity and QT interval duration: results from the Third national health and nutritional examination survey. PLoS One 2011;6(2):e17584.Haverkamp W., Breithardt G., Camm A. J. et al The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: Clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology. Cardiovascular Research 2000;47:219–33.Haverkamp W., Breithardt G., Camm A. J. et al The potential for QT prolongation and pro-arrhythmia by non-anti-arrhythmic drugs: Clinical and regulatory implications. Report on a Policy Conference of the European Society of Cardiology. Cardiovascular Research 2000;47:219–33.Yap Y. G., Camm A. J. Drug induced QT prolongation and torsades de pointes. Heart 2003;89:1363– 72.Yap Y. G., Camm A. J. Drug induced QT prolongation and torsades de pointes. Heart 2003;89:1363– 72.Kowey P.R., Malik M. The QT interval as it relates to the safety of non-cardiac drugs. Eur Heart J Suppl 2007;9 (Supplement G):G3–G8.Kowey P.R., Malik M. The QT interval as it relates to the safety of non-cardiac drugs. Eur Heart J Suppl 2007;9 (Supplement G):G3–G8.Gupta A., Lawrence A. T., Krishnan K. et al Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes. Am Heart J 2007;153:891–9.Gupta A., Lawrence A. T., Krishnan K. et al Current concepts in the mechanisms and management of drug-induced QT prolongation and torsade de pointes. Am Heart J 2007;153:891–9.Roden D. Drug-Induced Prolongation of the QT Interval. N Engl J Med 2004;350:1013–22.Roden D. Drug-Induced Prolongation of the QT Interval. N Engl J Med 2004;350:1013–22.Drew B.J., Ackerman M.J., Funk M. et al Prevention of Torsade de Pointes in Hospital Settings: A Scientific Statement From the American Heart Association and the American College of Cardiology Foundation. Circulation 2010;121:1047–60.Drew B.J., Ackerman M.J., Funk M. et al Prevention of Torsade de Pointes in Hospital Settings: A Scientific Statement From the American Heart Association and the American College of Cardiology Foundation. Circulation 2010;121:1047–60.Zipes D.P., Camm A.J., Borggrefe M. et al ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Car- diology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol 2006;48:e247– e346.Zipes D.P., Camm A.J., Borggrefe M. et al ACC/AHA/ESC 2006 guidelines for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death: a report of the American College of Cardiology/American Heart Association Task Force and the European Society of Car- diology Committee for Practice Guidelines (Writing Committee to Develop Guidelines for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death). J Am Coll Cardiol 2006;48:e247– e346.Straus M., Sturkenboom M.C., Bleumink G.S. Non-cardiac QTc-prolonging drugs and the risk of sudden cardiac death. Eur Heart J 2005;26:2007–12.Straus M., Sturkenboom M.C., Bleumink G.S. Non-cardiac QTc-prolonging drugs and the risk of sudden cardiac death. Eur Heart J 2005;26:2007–12.Roden D. M. Long QT syndrome: reduced repolarization reserve and the genetic link. Journal of Internal Medicine 2006;259:59–69.Roden D. M. Long QT syndrome: reduced repolarization reserve and the genetic link. Journal of Internal Medicine 2006;259:59–69.Jamshidi Y., Nolte I.M., Dalageorgou C. et al Common Variation in the NOS1AP Gene Is Associated With Drug-Induced QT Prolongation and Ventricular Arrhythmia. J Am Coll Cardiol 2012;60:841– 50.Jamshidi Y., Nolte I.M., Dalageorgou C. et al Common Variation in the NOS1AP Gene Is Associated With Drug-Induced QT Prolongation and Ventricular Arrhythmia. J Am Coll Cardiol 2012;60:841– 50.Simons G.R., Eisenstein E.L., Shaw L..J, Mark D.B. Cost effectiveness of inpatient initiation of antiarrhythmic therapy for supraventricular tachycardia’s. Am J Cardiol 1997;80:1551–7.Simons G.R., Eisenstein E.L., Shaw L..J, Mark D.B. Cost effectiveness of inpatient initiation of antiarrhythmic therapy for supraventricular tachycardia’s. Am J Cardiol 1997;80:1551–7.Ritter J. M. Cardiac safety, drug-induced QT prolongation and torsade de pointes (TdP). Br J Clin Pharmacol 2012;3(73):331–4.Ritter J. M. Cardiac safety, drug-induced QT prolongation and torsade de pointes (TdP). Br J Clin Pharmacol 2012;3(73):331–4.Lopatin Y.M. Diuretics and the development of hyperkalemia in patients with arterial hypertension: Are the security of the original and generic drugs. Atmosphere. Cardiology 2004; (3):12–5. Russian (Лопатин Ю.М. Диуретики и развитие гиперкалиемии у больных артериальной гипертонией: одинакова ли безопасность оригинальных и генерических препаратов. Атмосфера. Кардиология 2004;(3):12–5).Lopatin Y.M. Diuretics and the development of hyperkalemia in patients with arterial hypertension: Are the security of the original and generic drugs. Atmosphere. Cardiology 2004; (3):12–5. Russian (Лопатин Ю.М. Диуретики и развитие гиперкалиемии у больных артериальной гипертонией: одинакова ли безопасность оригинальных и генерических препаратов. Атмосфера. Кардиология 2004;(3):12–5).National Guidelines for the determining of risk and prevention of sudden cardiac death (draft). Available at: http://www.scardio.ru/downloads/c4m1i1153/ВССрекомендации.pdf. Date of accessNational Guidelines for the determining of risk and prevention of sudden cardiac death (draft). Available at: http://www.scardio.ru/downloads/c4m1i1153/ВССрекомендации.pdf. Date of access06.2013. Russian (Национальные Рекомендации по определению риска и профилактике внезапной сердечной смерти (проект). Доступен на: http://www.scardio.ru/downloads/c4m1i1153/ВСС рекомендации.pdf. Дата доступа: 22.06.2013).06.2013. Russian (Национальные Рекомендации по определению риска и профилактике внезапной сердечной смерти (проект). Доступен на: http://www.scardio.ru/downloads/c4m1i1153/ВСС рекомендации.pdf. Дата доступа: 22.06.2013).Mizusawa Y., Wilde A. A. M. QT Prolongation and Mortality in Hospital Settings: Identifying Patients at High Risk. Mayo Clin Proc 2013;88(4):309–11.Mizusawa Y., Wilde A. A. M. QT Prolongation and Mortality in Hospital Settings: Identifying Patients at High Risk. Mayo Clin Proc 2013;88(4):309–11.Freeman B.D., Dixon D.J., Coopersmith C.M. et al Pharmacoepidemiology of QT-interval prolonging drug administration in critically ill patients. Pharmacoepidemiol Drug Saf 2008;17(10):971–81.Freeman B.D., Dixon D.J., Coopersmith C.M. et al Pharmacoepidemiology of QT-interval prolonging drug administration in critically ill patients. Pharmacoepidemiol Drug Saf 2008;17(10):971–81.Pickham D., Helfenbein E., Shinn J. A. et al High prevalence of corrected QT interval prolongation in acutely ill patients is associated with mortality: Results of the QT in Practice (QTIP) Study. Critical Care Medicine 2012;2(40):394–9. 316-322.Pickham D., Helfenbein E., Shinn J. A. et al High prevalence of corrected QT interval prolongation in acutely ill patients is associated with mortality: Results of the QT in Practice (QTIP) Study. Critical Care Medicine 2012;2(40):394–9. 316-322.

The authors declare that there are no conflicts of interest present.