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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2006-2-1-27-30</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-1000</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group></article-categories><title-group><article-title>EFFECT OF ANTIHYPERTENSIVE THERAPY WITH RILMENIDINE ON COGNITIVE FUNCTION IN ELDERLY HYPERTENSIVE PATIENTS</article-title><trans-title-group xml:lang="ru"><trans-title>ВЛИЯНИЕ ГИПОТЕНЗИВНОЙ ТЕРАПИИ РИЛМЕНИДИНОМ НА КОГНИТИВНЫЕ ФУНКЦИИ У БОЛЬНЫХ АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ ПОЖИЛОГО ВОЗРАСТА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Недогода</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nedogoda</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра терапии и семейной медицины</p></bio><bio xml:lang="en"><p>Department of therapy and family medicine</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Брель</surname><given-names>У. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Brel</surname><given-names>U. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра терапии и семейной медицины</p></bio><bio xml:lang="en"><p>Department of therapy and family medicine</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чаляби</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tchalyaby</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра терапии и семейной медицины</p></bio><bio xml:lang="en"><p>Department of therapy and family medicine</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кесарева</surname><given-names>Э. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Kesareva</surname><given-names>E. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра терапии и семейной медицины</p></bio><bio xml:lang="en"><p>Department of therapy and family medicine</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цома</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Tcoma</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кафедра терапии и семейной медицины</p></bio><bio xml:lang="en"><p>Department of therapy and family medicine</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>ФУВ Волгоградского государственного медицинского университета</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Volgograd state medical university</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>23</day><month>01</month><year>2016</year></pub-date><volume>2</volume><issue>1</issue><fpage>27</fpage><lpage>30</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Nedogoda S.V., Brel U.A., Tchalyaby T.A., Kesareva E.S., Tcoma V.A., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Недогода С.В., Брель У.А., Чаляби Т.А., Кесарева Э.С., Цома В.А.</copyright-holder><copyright-holder xml:lang="en">Nedogoda S.V., Brel U.A., Tchalyaby T.A., Kesareva E.S., Tcoma V.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/1000">https://www.rpcardio.online/jour/article/view/1000</self-uri><abstract><p>Aim.  To assess antihypertensive efficacy of rilmenidine (Albarel, EGIS, Hungary) and its effect on cognitive function in elderly hypertensive patients. Material and methods. 30 elderly (in average 68 y.o.) hypertensive patients were observed. Each patient received therapy with rilmenidine 2 mg daily during 6 months. 24 hours monitoring of blood pressure before and after therapy was done in each patient. In order to assess cognitive disorders all patients passed neuropsychological tests, which allowed revealing damages of memory, attention, concentration, mental efficiency and psychomotor functions. Raten tests, Veksler test, vocal activity, memory (10 words), serial counting and kinetic probes were used. Results. After 24 weeks of monotherapy with rilmenidine, decrease in daily average systolic blood pressure (SBP) by 7.2% (p&lt;0.01) and diastolic blood pressure (DBP) by 5.5% (p&lt;0.05) was observed. Therapy with rilmenidine showed decrease in daily average burden by SBP and by DBP (by 25.3% and 18.8% respectively; p&lt;0.05) and daily average time index of hypertension for SBP and DBP (by 32.5 and 60.6% respectively; p&lt;0.05) According to the results of neuropsychological tests at the end of treatment, average time for Raten test completion decreased by 16.7% (p&lt;0.05), and for Veksler test completion – by 15.6% (p&lt;0.05). At the same time significant increase in vocal activity of patients is noted: number of words at free associations tests, verbs and plants denomination have grown by 5.8%, 5.1% and 6.3% respectively (p&lt;0.05); number of mistakes in these tests decreased respectively by 71.4%, 50% and 33.3% (p&lt;0.05). Positive dynamics in characteristics of memory: number of words at first and last immediate and postponed reproduction increased respectively by 36.4%, 21.6% and 14.1% (p&lt;0.05),  average time of serial counting and average time of memorization decreased respectively by 13.2% and 31.8% (p&lt;0.05). Velocity in both hands increased, which was observed both in tests on grip and fingering, and on reciprocal coordination. Conclusion. Well-defined antihypertensive effect of rilmenidine in elderly AH patients is accompanied by significant improvement of cognitive functions. This greatly expands opportunities of treatment with rilmenidine in this age group.</p></abstract><trans-abstract xml:lang="ru"><p>Цель. Цель. Оценить антигипертензивный эффект агониста имидазолиновых рецепторов рилменидина (Альбарел, ЭГИС, Венгрия) и его влияние на когнитивную функцию у пожилых больных артериальной гипертензией (АГ). Материал и методы. Обследовано 30 пожилых больных (возраст, в среднем, 68 лет) АГ.  Всем больным назначали рилменидин в дозе 2 мг в сутки. Длительность терапии составила 6 месяцев. Всем больным исходно и в конце периода наблюдения проводили суточное мониторирование артериального давления. Для оценки когнитивных нарушений до и после медикаментозного лечения рилменидином все больные проходили нейропсихологическое тестирование, позволявшее выявить и оценить  когнитивные расстройства, а именно: нарушение памяти, внимания, концентрации, умственной работоспособности и психомоторной функции. Для этого использовались: тест Рейтена, тест Векслера, проба на речевую активность, запоминание (10 слов) и серийный счет, кинетическая проба. Результаты. Через 24 недели монотерапии рилменидином  наблюдалось снижение среднесуточного систолического артериального давления (САД) на 7.2% (p&lt;0.01)  и диастолического артериального давления (ДАД) на 5.5% (р&lt;0.05). Благодаря терапии рилменидином наблюдалось снижение среднесуточных показателей нагрузки по САД и ДАД  (соответственно на 25.3% и 18.8%; р &lt; 0.05.) и  среднесуточного индекса времени гипертензии по САД и ДАД (соответственно на 32.5% и 60.6%; р &lt; 0.05). По результатам нейропсихологического тестирования в конце лечения уменьшалось среднее время выполнения теста Рейтана (на 16.7%; р&lt;0.05), теста Векслера (на 15.6%; р&lt;0.05). При этом зафиксировано достоверное повышение речевой активности больных: увеличилось количество слов при выполнении пробы на свободные ассоциации,  называние глаголов и растений соответственно на 5.8%, 5.1% и 6.3% (р&lt;0.05); кроме того уменьшилось количество допускаемых ошибок соответственно на 71.4%, 50% и 33.3% (р&lt;0.05). Отмечалась положительная динамика показателей памяти: увеличилось количество слов при первом и последнем непосредственном и отсроченном  воспроизведениях соответственно на 36.4%, 21.6% и 14.1%  (р&lt;0.05), уменьшилось среднее время серийного счета и среднее время запоминания соответственно на 13.2% и 31.8% (р&lt;0.05). Также увеличилась скорость движений в обеих руках, что наблюдалось как в пробах на сжатие кисти и перебор пальцев, так и в пробе на реципрокную координацию. Заключение.  Выраженный антигипертензивный эффект рилменидина у пожилых больных АГ сочетается со значительным улучшением когнитивных функций. Это существенно расширяет возможности применения рилменидина в данной возрастной группе.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>рилменидин</kwd><kwd>артериальная гипертензия</kwd><kwd>когнитивные нарушения</kwd></kwd-group><kwd-group xml:lang="en"><kwd>rilmenidine</kwd><kwd>arterial hypertension</kwd><kwd>cognitive disfunctions</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Остроумова О.Д,. Корсакова Н.K., Баграмова Ю.А. Деменция и артериальная гипертензия у пожилых больных: возможности препарата Физиотенз. РМЖ 2002;10(1):7–10.</mixed-citation><mixed-citation xml:lang="en">Остроумова О.Д,. Корсакова Н.K., Баграмова Ю.А. Деменция и артериальная гипертензия у пожилых больных: возможности препарата Физиотенз. 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