rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2006-2-3-56-64rpcardio-1034Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИAPPLICATION OF CALCIUM ANTAGONISTS IN PREVENTION OF CARDIOVASCULAR COMPLICATIONS DURING CARDIAC SURGERYПРИМЕНЕНИЕ АНТАГОНИСТОВ КАЛЬЦИЯ ДЛЯ ПРОФИЛАКТИКИ СЕРДЕЧНО-СОСУДИСТЫХ ОСЛОЖНЕНИЙ ПРИ ОПЕРАЦИЯХ НА СЕРДЦЕНедогодаС. В.NedogodaS. V.Волгоградский государственный медицинский университетРоссияVolgograd Medical State UniversityRussian Federation200624012016235664Copyright © Nedogoda S.V., 20162016Недогода С.В.Nedogoda S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1034

Results of randomized clinical trials on the usage of calcium antagonists (CA) in order to prevent perioperative complications during aortocoronary bypass procedure and operations on heart valves are analyzed. CA reduced the risk of perioperative myocardial infarctions and episodes of reversible myocardial ischemia. After angioplasty of coronary arteries CA (particularly amlodipine) show positive effects on restenosis incidence and reduce about 3 times a number of repeated angioplasty and aortocoronary bypass operations. The use of CA was accompanied by more often need in heart electro stimulation without any subclass differences. It is also registered that nimodipine can strengthen intraoperative blood loss. It is concluded, that CA have significant evident base that allows recommending them to patients undertaken by cardiological surgery.

Рассматриваются результаты рандомизированных клинических исследований по применению антагонистов кальция (АК) с целью предупреждения периоперационных осложнений при аортокоронарном шунтировании и операциях на клапанах сердца. АК уменьшали риск развития периоперационных инфарктов и эпизодов обратимой ишемии миокарда. После ангиопластики коронарных артерий АК (в частности амлодипин) оказывают положительное влияние на частоту рестенозов и почти в 3 раза снижают число повторных ангиопластик и операций аортокоронарного шунтирования. Применение АК сопровождалось более частой необходимостью электростимуляции сердца без различий по подклассам. Отмечается также, что нимодипин может усиливать интраоперационную кровопотерю. Делают вывод о том, что АК имеют весомую доказательную базу, позволяющую рекомендовать их применение у кардиохирургических пациентов.

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The authors declare that there are no conflicts of interest present.