rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2013-9-4-420-426rpcardio-107Research ArticlePOINT OF VIEWТОЧКА ЗРЕНИЯUSE OF BETA-BLOCKERS IN THE PERIOPERATIVE PERIOD: HOW STRONG ARE THE EVIDENCES?ПРИМЕНЕНИЕ БЕТА-АДРЕНОБЛОКАТОРОВ В ПЕРИОПЕРАЦИОННОМ ПЕРИОДЕ: НАСКОЛЬКО УБЕДИТЕЛЬНЫ ДОКАЗАТЕЛЬСТВА?СамойленкоВ. В.SamoylenkoV. V.

Кандидат медицинских наук,  доцент кафедры кардиологии

vvsamdoctor@gmail.comШевченкоО. П.ShevchenkoO. P.

Доктор медицинских наук, профессор, заведующий кафедрой кардиологии

vvsamdoctor@gmail.comБурцевВ. И.BurtsevV. I.

Доктор медицинских наук, профессор кафедры семейной медицины факультета послевузовского профессионального образования врачей

vvsamdoctor@gmail.comРоссийский национальный исследовательский медицинский университет имени Н.И. ПироговаРоссияRussian National Research Medical University named after N.I. Pirogov, MoscowRussian FederationПервый Московский медицинский университет имени И.М. Сеченова, МоскваРоссияI.M. Setchenov First Moscow State Medical University, MoscowRussian Federation20132209201594420426Copyright © Samoylenko V.V., Shevchenko O.P., Burtsev V.I., 20152015Самойленко В.В., Шевченко О.П., Бурцев В.И.Samoylenko V.V., Shevchenko O.P., Burtsev V.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/107

Optimization of the pharmacotherapy in preoperative period is the cornerstone of the concept of risk modification of cardiovascular complications in the perioperative period. Therefore, special attention has recently been focused on the use of beta-blockers in the postoperative period. Nowadays convincing evidence base for the use of this class of drugs in the perioperative period that was the basis for the development of clinical guidelines is accumulated. Moreover, results of large randomized trials of beta-blockers are controversial. This has resulted in significant differences in the classes of recommendations and levels of evidence.Analysis of the results of basic researches and the provisions of recommendations of the international and national professional medical societies on the use of beta-blockers in patients with cardiovascular disease to reduce the risk of cardiac complications in the perioperative period for planned extracardiac surgical procedures is presented.

Оптимизация лекарственной терапии в предоперационном периоде является краеугольным камнем концепции модификации риска развития сердечно-сосудистых осложнений в периоперационном периоде, и в этой связи особое внимание в последнее время уделяется применению бета-адреноблокаторов. К настоящему времени накоплена убедительная доказательная база по применению данного класса препаратов в периоперационном периоде, послужившая основой для разработки клинических рекомендаций. В то же время результаты крупных рандомизированных исследований по изучению применения бета-адреноблокаторов носят противоречивый характер, в связи с чем их неоднозначная интерпретация привела к появлению существенных различий в классах рекомендаций и уровнях их доказательности.Проведен анализ результатов основных исследований и положений рекомендаций международных и национальных профессиональных медицинских обществ в отношении применения бета-адреноблокаторов у пациентов с сердечно-сосудистыми заболеваниями с целью снижения риска развития кардиальных осложнений в периоперационном периоде при плановых внесердечных хирургических вмешательствах.

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The authors declare that there are no conflicts of interest present.