rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2008-4-2-13-18rpcardio-1074Research ArticleORIGINAL STUDIESОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯCLINICAL AND GENETIC PECULIARITIES OF ATRIAL FIBRILLATIONКЛИНИКО–ГЕНЕТИЧЕСКИЕ ОСОБЕННОСТИ ФИБРИЛЛЯЦИИ ПРЕДСЕРДИЙНикулинаC. Ю.NikulinaS. Y.ШульманВ. А.SchulmanV. A.КузнецоваО. О.KuznetsovaO. O.АксютинаН. В.AksjutinaN. V.ШестерняП. А.ShesternjaP. A.ЧерноваА. А.ChernovaA. A.МаксимовВ. Н.MaksimovV. N.КуликовИ. В.KulikovI. V.УстиновС. Н.UstinovS. N.КазариноваЮ. Л.KazarinovaY. L.РомащенкоА. Г.RomashchenkoA. G.ВоеводаМ. И.VoevodaM. I.Красноярская Государственная медицинская академия Научно-исследовательский институт терапии Сибирского отделения Российской академии медицинских наук, Новосибирск Институт цитологии и генетики Сибирского отделения Российской академии наук, НовосибирскРоссияKrasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, NovosibirskRussian FederationKrasnoyarsk State Medical Academy Research Institute of Therapy, Siberian Branch of Russian Academy of Medical Sciences, Novosibirsk Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, NovosibirskRussian Federation200827012016421318Copyright © Nikulina S.Y., Schulman V.A., Kuznetsova O.O., Aksjutina N.V., Shesternja P.A., Chernova A.A., Maksimov V.N., Kulikov I.V., Ustinov S.N., Kazarinova Y.L., Romashchenko A.G., Voevoda M.I., 20162016Никулина C.Ю., Шульман В.А., Кузнецова О.О., Аксютина Н.В., Шестерня П.А., Чернова А.А., Максимов В.Н., Куликов И.В., Устинов С.Н., Казаринова Ю.Л., Ромащенко А.Г., Воевода М.И.Nikulina S.Y., Schulman V.A., Kuznetsova O.O., Aksjutina N.V., Shesternja P.A., Chernova A.A., Maksimov V.N., Kulikov I.V., Ustinov S.N., Kazarinova Y.L., Romashchenko A.G., Voevoda M.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1074Aim

Aim. To study inheritance patterns of atrial fibrillation (AF) and association of primary and secondary AF with gene polymorphism of β1-adrenoreceptors.

Material and methods

Material and methods. 103 probands with AF and their 301 relatives of I, II, III degrees (basic group) and 82 probands without heart diseases and their 163 relatives of I and II degrees (control group) were examined. Examination included evaluation of electrophysiological indicators of sinoatrial node, electrocardiogram monitoring, veloergometry, echocardiography as well as assessment of gene polymorphism of β1-adrenoretseptors.

Results

Results. Accumulation of AF in probands families was founded. Segregation analysis of idiopathic AF revealed autosomal-dominant type of its inheritance.

Сonclusion

Сonclusion. The heterozygote genotype of gene β1-adrenoretseptors Ser49Gly is one of genetic predictors of primary and secondary AF.

Цель

Цель. Установить вероятность и закономерности наследования фибрилляции предсердий (ФП) в семьях, изучить связь первичной и вторичной ФП с полиморфизмом гена β1-адренорецепторов.

Материал и методы

Материал и методы. Обследованы 103 пробанда, у которых диагностирована ФП, и их 301 родственник I, II, III степени родства (основная группа) и 82 пробанда, у которых отсутствовали проявления заболеваний сердца, и их 163 родственника I и II степени родства (контрольная группа). Обследование включало определение электрофизиологических показателей функции синусового узла, суточное мониторирование ЭКГ, велоэргометрию, эхокардиографию, а также изучение полиморфизма гена β1-адренорецепторов.

Результаты

Результаты. Выявлено накопление ФП в семьях пробандов. Сегрегационный анализ идиопатических форм ФП выявил аутосомно-доминантный тип ее наследования.

Заключение

Заключение. Гетерозиготный вариант генотипа гена β1-адренорецепторов Ser49Gly можно рассматривать как один из генетических предикторов возникновения как первичной, так и вторичной ФП.

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The authors declare that there are no conflicts of interest present.