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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2008-4-1-126-131</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-1082</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>EVIDANCE BASED MEDICINE</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ДОКАЗАТЕЛЬНАЯ МЕДИЦИНА</subject></subj-group></article-categories><title-group><article-title>THE STUDY ADVANCE: RESULTS REQUIRING EXPLANATIONS</article-title><trans-title-group xml:lang="ru"><trans-title>ИССЛЕДОВАНИЕ ADVANCE: РЕЗУЛЬТАТЫ, ТРЕБУЮЩИЕ ОБЪЯСНЕНИЙ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Александров</surname><given-names>Ан. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Alexandrov</surname><given-names>An. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>Эндокринологический научный центр Росмедтехнологий, Москва</institution><country>Russian Federation</country></aff><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>28</day><month>01</month><year>2016</year></pub-date><volume>4</volume><issue>1</issue><fpage>126</fpage><lpage>131</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Alexandrov A.A., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Александров А.А.</copyright-holder><copyright-holder xml:lang="en">Alexandrov A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/1082">https://www.rpcardio.online/jour/article/view/1082</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="ru"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Adler A.I, Stratton I.M., Neil H.A, et al. 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