rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2008-4-2-53-57rpcardio-1093Research ArticlePOINT OF VIEWТОЧКА ЗРЕНИЯDIHYDROPYRIDINE CALCIUM ANTAGONISTS: THE ROLE IN CURRENT THERAPY OF CARDIO-VASCULAR DISEASESДИГИДРОПИРИДИНОВЫЕ АНТАГОНИСТЫ КАЛЬЦИЯ: РОЛЬ В СОВРЕМЕННОЙ ТЕРАПИИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙШиловаЕ. В.ShilovaE. V.МарцевичС. Ю.MartsevichS. Y.Государственный научно-исследовательский центр профилактической медицины Росмедтехнологий, МоскваРоссияState Research center of preventive medicine of Rosmedtechnology, MoscowRussian Federation200829012016425357Copyright © Shilova E.V., Martsevich S.Y., 20162016Шилова Е.В., Марцевич С.Ю.Shilova E.V., Martsevich S.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1093

Classification of calcium antagonists (CA) is presented. Results of the large clinical trials (STONE, STOP-Hypertension-2, ALLHAT, ASCOT-BPLA etc.) devoted to estimation of CA effects on the risk of cardiovascular complications are analyzed. The significant place of dihydropyridine CA in current guidelines on arterial hypertension and ischemic heart disease therapy is underlined. Results of a pilot study on comparison of two amlodipines (original Norvasc and generic Stamlo M) are discussed.

Приводится классификация антагонистов кальция (АК). Анализируются результаты крупных исследований (STONE, STOP-Hypertension-2, ALLHAT, ASCOT-BPLA и др.) по оценке влияния АК на риск сердечно-сосудистых осложнений. Отмечается место дигидропиридиновых АК в современных рекомендациях по лечению артериальной гипертонии и ишемической болезни сердца. Приведены результаты пилотного исследования по сравнению эффективности двух препаратов амлодипина – оригинального Норваска и дженерика Стамло М.

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The authors declare that there are no conflicts of interest present.