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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2008-4-2-76-80</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-1096</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CURRENT QUESTIONS OF CLINICAL PHARMACOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ  ВОПРОСЫ  КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>FROM THE SHORT ACTING NIFEDIPINE TO AMLODIPINE AND FIXED COMBINATIONS. HIGHLIGHTS THE PROBLEM FROM THE CURRENT GUIDELINES POINT OF VIEW</article-title><trans-title-group xml:lang="ru"><trans-title>ОТ КОРОТКОДЕЙСТВУЮЩЕГО НИФЕДИПИНА К АМЛО- ДИПИНУ И ФИКСИРОВАННЫМ КОМБИНАЦИЯМ. ПРО- БЛЕМА В СВЕТЕ СОВРЕМЕННЫХ РЕКОМЕНДАЦИЙ ПО ЛЕЧЕНИЮ АРТЕРИАЛЬНОЙ ГИПЕРТОНИИ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кательницкая</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Katelnitskaya</surname><given-names>L. I.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Хаишева</surname><given-names>Л. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Haisheva</surname><given-names>L. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Ростовский государственный медицинский университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Rostov State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>29</day><month>01</month><year>2016</year></pub-date><volume>4</volume><issue>2</issue><fpage>76</fpage><lpage>80</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Katelnitskaya L.I., Haisheva L.A., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Кательницкая Л.И., Хаишева Л.А.</copyright-holder><copyright-holder xml:lang="en">Katelnitskaya L.I., Haisheva L.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/1096">https://www.rpcardio.online/jour/article/view/1096</self-uri><abstract><p>Calcium antagonists (CA) therapy of patients with arterial hypertension is focused on the base of current recommendations. Results of some large clinical trials confirm high antihypertensive efficacy of this therapeutic class. Special attention is devoted to implementation of fixed combinations on the basis of CA. Advantages of these combinations in hypertension therapy are discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Статья посвящена применению антагонистов кальция (АК) при артериальной гипертонии (АГ) с позиций современных рекомендаций. Приведены данные крупных исследований, подтверждающих высокую антигипертензивную эффективность этого класса препаратов. Особое внимание уделяется применению при АГ фиксированных комбинаций с АК, обосновываются их преимущества по сравнению со стандартной терапией.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертония</kwd><kwd>антагонисты кальция</kwd><kwd>фиксированные комбинации</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial hypertension</kwd><kwd>calcium antagonists</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Национальные рекомендации по профилактике, диагностике и лечению ар- териальной гипертонии (Второй пересмотр). Кардиоваскулярная терапия и профилактика 2004; 3(3):105–20.</mixed-citation><mixed-citation xml:lang="en">Национальные рекомендации по профилактике, диагностике и лечению ар- териальной гипертонии (Второй пересмотр). Кардиоваскулярная терапия и профилактика 2004; 3(3):105–20.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">National Institute for Health and Clinical Excellence. Hypertension: management of hypertension in adults in primary care partial update. London: National Institute for Health and Clinical Excellence; 2006.</mixed-citation><mixed-citation xml:lang="en">National Institute for Health and Clinical Excellence. Hypertension: management of hypertension in adults in primary care partial update. London: National Institute for Health and Clinical Excellence; 2006.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">The Task Force for the management of arterial hypertension of the European Society of Hypertension and of the European Society of Cardiolody. 2007 Guidelines for the management of arterial hypertension. J Hypertens 2007; 25: 1105– 87.</mixed-citation><mixed-citation xml:lang="en">The Task Force for the management of arterial hypertension of the European Society of Hypertension and of the European Society of Cardiolody. 2007 Guidelines for the management of arterial hypertension. J Hypertens 2007; 25: 1105– 87.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">MacMahon S, Chalmers J. Blood pressure lowering and ACE inhibition for the avoidance of cardiac and cerebral events. Eur Heart J 2003;24(5):391-3.</mixed-citation><mixed-citation xml:lang="en">MacMahon S, Chalmers J. Blood pressure lowering and ACE inhibition for the avoidance of cardiac and cerebral events. Eur Heart J 2003;24(5):391-3.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Карпов Ю.А. Применение антагонистов кальция у больных артериальной ги- пертонией и ишемической болезнью сердца: современное состояние вопроса. Кардиология 2000;(10):52-5.</mixed-citation><mixed-citation xml:lang="en">Карпов Ю.А. Применение антагонистов кальция у больных артериальной ги- пертонией и ишемической болезнью сердца: современное состояние вопроса. Кардиология 2000;(10):52-5.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Метелица В.И. Справочник по клинической фармакологии сердечно–сосу- дистых лекарственных средств. М.: Бином; 2002.</mixed-citation><mixed-citation xml:lang="en">Метелица В.И. Справочник по клинической фармакологии сердечно–сосу- дистых лекарственных средств. М.: Бином; 2002.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Psaty B.M., Heckbert S.R., Koepsell T.D. et al. The risk of myocardial infarction associated with antihypertensive drug therapies. JAMA 1995; 274: 620-25.</mixed-citation><mixed-citation xml:lang="en">Psaty B.M., Heckbert S.R., Koepsell T.D. et al. The risk of myocardial infarction associated with antihypertensive drug therapies. JAMA 1995; 274: 620-25.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Furberg C.D., Psaty B.M., Meyer J.V. Nifedipine. Dose-related increase in mortality in patients with coronary heart disease. Circulation 1995; 92: 1326-31.</mixed-citation><mixed-citation xml:lang="en">Furberg C.D., Psaty B.M., Meyer J.V. Nifedipine. Dose-related increase in mortality in patients with coronary heart disease. Circulation 1995; 92: 1326-31.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Pahor M., Gurinik J.M., Corti M.C. et al. Long-term survival and use of antihypertensive medications in older persons. J Am Geriatr Soc 1995;43:1191-7.</mixed-citation><mixed-citation xml:lang="en">Pahor M., Gurinik J.M., Corti M.C. et al. Long-term survival and use of antihypertensive medications in older persons. J Am Geriatr Soc 1995;43:1191-7.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Malacoff R.F., Lorell B.H., Mudge G.H. et al. Beneficial effects of nifedipine on regional myocardial blood flow in patients with coronary artery disease. Circulation 1982; 65 (1 Pt 2): I32-I37.</mixed-citation><mixed-citation xml:lang="en">Malacoff R.F., Lorell B.H., Mudge G.H. et al. Beneficial effects of nifedipine on regional myocardial blood flow in patients with coronary artery disease. Circulation 1982; 65 (1 Pt 2): I32-I37.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Kugiyama K., Yasue H., Horio Y. et al. Effects of propranolol and nifedipine on exercise-induced attack in patients variant angina: assessment by exercise thallium- 201 myocardial scintigraphy with quantitative rotational tomography. Circulation 1986;74 (2):374-80.</mixed-citation><mixed-citation xml:lang="en">Kugiyama K., Yasue H., Horio Y. et al. Effects of propranolol and nifedipine on exercise-induced attack in patients variant angina: assessment by exercise thallium- 201 myocardial scintigraphy with quantitative rotational tomography. Circulation 1986;74 (2):374-80.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Warwick D. FDA gives calcium channel blockers clean bill of health but warns of short-acting nifedipine hazards. JAMA 1996; 275:423-4.</mixed-citation><mixed-citation xml:lang="en">Warwick D. FDA gives calcium channel blockers clean bill of health but warns of short-acting nifedipine hazards. JAMA 1996; 275:423-4.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Марцевич С.Ю. Нифедипин. Различные лекарственные формы в лечении сердечно-сосудистых заболеваний. Кардиология 1998;(11):66-74.</mixed-citation><mixed-citation xml:lang="en">Марцевич С.Ю. Нифедипин. Различные лекарственные формы в лечении сердечно-сосудистых заболеваний. Кардиология 1998;(11):66-74.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mason R.P., Walter M.F., Trumbore M.W. et al. Membrane antioxidant effects of the charged dihydropyridine calcium antagonist amlodipine. J Mol Cell Cardiol 1999;31:275-81</mixed-citation><mixed-citation xml:lang="en">Mason R.P., Walter M.F., Trumbore M.W. et al. Membrane antioxidant effects of the charged dihydropyridine calcium antagonist amlodipine. J Mol Cell Cardiol 1999;31:275-81</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Pitt B, Byington RP, Furberg CD et al. Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events. PREVENT Investigators. Circulation 2000;102(13):1503-10.</mixed-citation><mixed-citation xml:lang="en">Pitt B, Byington RP, Furberg CD et al. Effect of amlodipine on the progression of atherosclerosis and the occurrence of clinical events. PREVENT Investigators. Circulation 2000;102(13):1503-10.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Zanchetti A., Bond G., Hennig M. et al. Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis: principal results of the European Lacidipine Study on Atherosclerosis (ELSA), a randomized, double-blind, long-term trial. Circulation 2002; 106: 2422–7</mixed-citation><mixed-citation xml:lang="en">Zanchetti A., Bond G., Hennig M. et al. Calcium antagonist lacidipine slows down progression of asymptomatic carotid atherosclerosis: principal results of the European Lacidipine Study on Atherosclerosis (ELSA), a randomized, double-blind, long-term trial. Circulation 2002; 106: 2422–7</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Nissen S.E., Tuzcu E.M., Libby P. et al. Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure. The CAMELOT study: a randomized controlled trial. JAMA 2004; 292: 2217– 26.</mixed-citation><mixed-citation xml:lang="en">Nissen S.E., Tuzcu E.M., Libby P. et al. Effect of antihypertensive agents on cardiovascular events in patients with coronary disease and normal blood pressure. The CAMELOT study: a randomized controlled trial. JAMA 2004; 292: 2217– 26.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Dahlöf B., Sever P.S., Poulter N.R. et al for the ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005;366:895- 906.</mixed-citation><mixed-citation xml:lang="en">Dahlöf B., Sever P.S., Poulter N.R. et al for the ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005;366:895- 906.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002; 288: 2981–97.</mixed-citation><mixed-citation xml:lang="en">ALLHAT Officers and Coordinators for the ALLHAT Collaborative Research Group. The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Major outcomes in high-risk hypertensive patients randomized to angiotensin-converting enzyme inhibitor or calcium channel blocker vs diuretic: The Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). JAMA 2002; 288: 2981–97.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Julius S, Kjeldsen SE, Weber M, et al. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 2004; 363: 2022–5.</mixed-citation><mixed-citation xml:lang="en">Julius S, Kjeldsen SE, Weber M, et al. Outcomes in hypertensive patients at high cardiovascular risk treated with regimens based on valsartan or amlodipine: the VALUE randomised trial. Lancet 2004; 363: 2022–5.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Hansson L., Zanchetti A., Carruthers S.G., et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet 1998;351:1755-62.</mixed-citation><mixed-citation xml:lang="en">Hansson L., Zanchetti A., Carruthers S.G., et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet 1998;351:1755-62.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Бойцов С.А. Комбинированная терапия артериальной гипертензии с позиций профилактики сердечно-сосудистыx осложнений и патогенеза. Consilium Medicum 2004; 2(приложение):23-6.</mixed-citation><mixed-citation xml:lang="en">Бойцов С.А. Комбинированная терапия артериальной гипертензии с позиций профилактики сердечно-сосудистыx осложнений и патогенеза. Consilium Medicum 2004; 2(приложение):23-6.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Farsang C. a HAMLET Vizsgalok neveben (2004) A lisinopril es az amlodipin kombinaciojanak elonyei az antihypertensiv terapiaban. A Hypertoniaban adott AMlodipin 5 mg es Lisinopril 10 mg tablettak hatekonysaganak es toleralhatosaganak osszehasonlito vizsgalata kulon es Egyutt alkalmazott Terapiakent (HAMLET). Multicentrikus vizsgalat eredmenyei. [Advantages of lisinopril amlodipin fix combination therapy in hypertension. A comparative study of the efficacy and tolerability of amlodipin 5 mg and lisinopril 10 mg administrated separately and in combination in hypertension] Hypertonia es nephrologia, 8(2):72–8.</mixed-citation><mixed-citation xml:lang="en">Farsang C. a HAMLET Vizsgalok neveben (2004) A lisinopril es az amlodipin kombinaciojanak elonyei az antihypertensiv terapiaban. A Hypertoniaban adott AMlodipin 5 mg es Lisinopril 10 mg tablettak hatekonysaganak es toleralhatosaganak osszehasonlito vizsgalata kulon es Egyutt alkalmazott Terapiakent (HAMLET). Multicentrikus vizsgalat eredmenyei. [Advantages of lisinopril amlodipin fix combination therapy in hypertension. A comparative study of the efficacy and tolerability of amlodipin 5 mg and lisinopril 10 mg administrated separately and in combination in hypertension] Hypertonia es nephrologia, 8(2):72–8.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Архипов В.В. Сочетание антагонистов кальция и ингибиторов АПФ у больных артериальной гипертензией. Врач 2007;(8): 62-4.</mixed-citation><mixed-citation xml:lang="en">Архипов В.В. Сочетание антагонистов кальция и ингибиторов АПФ у больных артериальной гипертензией. Врач 2007;(8): 62-4.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Маколкин В.И. Совершенствование комбинированной терапии – путь к улучшению результатов лечения артериальной гипертонии. РМЖ 2007; 15(16):1238–41.</mixed-citation><mixed-citation xml:lang="en">Маколкин В.И. Совершенствование комбинированной терапии – путь к улучшению результатов лечения артериальной гипертонии. РМЖ 2007; 15(16):1238–41.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
