rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2013-9-4-444-447rpcardio-111Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИSTATINS AND THE RISK OF DIABETES MELLITUSСТАТИНЫ И РИСК РАЗВИТИЯ САХАРНОГО ДИАБЕТАДрапкинаО. М.DrapkinaO. M.

Доктор медицинских наук, профессор кафедры пропедевтики внутренних болезней

drapkina@bk.ruПервый Московский медицинский университет имени И.М. Сеченова, МоскваРоссияI.M. Sechenov First Moscow State Medical University, MoscowRussian Federation20132209201594444447Copyright © Drapkina O.M., 20152015Драпкина О.М.Drapkina O.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/111

Randomized controlled trials have clearly demonstrated the efficacy of statins in reduction of serum low density lipoprotein cholesterol level by 25-50% from the baseline. Statins may increase the risk of diabetes mellitus (DM) in long-term therapy and use of high doses. Diabetogenic action is statins class effect and does not depend on their hydrophobic or hydrophilic properties. However, the use of statins in patients with DM is obligatory. The statins diabetogenic  risk is exaggerated and we will continue to treat our patients with statins.

Результаты рандомизированных контролируемых исследований убедительно продемонстрировали эффективность статинов в снижении сывороточного уровня холестерина липопротеинов низкой плотности на 25-50% от исходного уровня. Статины могут повышать риск сахарного диабета (СД) при длительном приеме и при применении высоких доз. Диабетогенный эффект статинов не зависит от гидро- или липофильности статинов, это общий класс-эффект. Однако у пациентов с СД применение статинов обязательно. Диабетогенный риск статинов преувеличен, и мы будем продолжать лечить наших пациентов статинами.

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The authors declare that there are no conflicts of interest present.