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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2013-9-1-86-89</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-114</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CURRENT QUESTIONS OF CLINICAL PHARMACOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ  ВОПРОСЫ  КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>THE EFFICACY AND SAFETY OF DIHYDROPYRIDINE CALCIUM CHANNEL BLOCKERS IN HYPERTENSIVE PATIENTS: AMLODIPINE PLACE</article-title><trans-title-group xml:lang="ru"><trans-title>ЭФФЕКТИВНОСТЬ И БЕЗОПАСНОСТЬ АНТАГОНИСТОВ КАЛЬЦИЯ ДИГИДРОПИРИДИНОВОГО РЯДА У БОЛЬНЫХ С АРТЕРИАЛЬНОЙ ГИПЕРТЕНЗИЕЙ: МЕСТО АМЛОДИПИНА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лебедева</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lebedeva</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">marinaamica@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бекетов</surname><given-names>В. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Beketov</surname><given-names>V. D.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">marinaamica@mail.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мальцева</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Maltsev</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">marinaamica@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сафарова</surname><given-names>М. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Safarova</surname><given-names>M. E.</given-names></name></name-alternatives><bio xml:lang="ru"/><email xlink:type="simple">marinaamica@mail.ru</email><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский медицинский университет им. И.М.Сеченова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Московский государственный университет им. М.В. Ломоносова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Lomonosov Moscow State University, Faculty of Fundamental Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Центральная поликлиника № 1 Министерства внутренних дел Российской Федерации.</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Central Outpatient Clinic № 1, Ministry of Internal Affairs of the Russian Federation</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2013</year></pub-date><pub-date pub-type="epub"><day>22</day><month>09</month><year>2015</year></pub-date><volume>9</volume><issue>1</issue><fpage>86</fpage><lpage>89</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Lebedeva M.V., Beketov V.D., Maltsev N.V., Safarova M.E., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Лебедева М.В., Бекетов В.Д., Мальцева Н.В., Сафарова М.Э.</copyright-holder><copyright-holder xml:lang="en">Lebedeva M.V., Beketov V.D., Maltsev N.V., Safarova M.E.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/114">https://www.rpcardio.online/jour/article/view/114</self-uri><abstract><p>Findings of the main clinical trials of amlodipine in the treatment of arterial hypertension and prevention of fatal and non-fatal cardiovascular events are presented.</p></abstract><trans-abstract xml:lang="ru"><p>Изложены данные основных клинических исследований амлодипина в лечении артериальной гипертензии и профилактике фатальных и нефатальных сердечно-сосудистых событий.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>амлодипин</kwd><kwd>артериальная гипертензия</kwd><kwd>доказательная медицина</kwd><kwd>клинические исследования</kwd></kwd-group><kwd-group xml:lang="en"><kwd>amlodipine</kwd><kwd>arterial hypertension</kwd><kwd>evidence-based medicine</kwd><kwd>clinical trials</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Toal C. 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