<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2008-4-4-76-79</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-1142</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group></article-categories><title-group><article-title>CARDIOVASCULAR EVENT RISK REDUCTION WITH MEDICINES: DATA OF EVIDENCE BASED MEDICINE AND RECOMMENDATIONS TO PRACTITIONERS</article-title><trans-title-group xml:lang="ru"><trans-title>СНИЖЕНИЕ РИСКА СЕРДЕЧНО-СОСУДИСТЫХ ОСЛОЖНЕНИЙ С ПОМОЩЬЮ ЛЕКАРСТВЕННЫХ ПРЕПАРАТОВ: ДАННЫЕ ДОКАЗАТЕЛЬНОЙ МЕДИЦИНЫ И РЕКОМЕНДАЦИИ ПРАКТИЧЕСКИМ ВРАЧАМ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Марцевич</surname><given-names>С. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Martsevich</surname><given-names>S. Y.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра доказательной медицины Московской медицинской академии им. И.М.Сеченова</p></bio><bio xml:lang="en"><p>Chair of Evidence Based Medicine of Moscow Medical Academy named after M.I. Setchenov</p></bio><email xlink:type="simple">smartsevich@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Государственный научно-исследовательский центр профилактической медицины Росмедтехнологий, 101990 Москва, Петроверигский пер., 10</institution><country>Россия</country></aff><aff xml:lang="en"><institution>State Research Center of Preventive Medicine of Rosmedtechnology, Petroverigsky per. 10, Moscow, 101990 Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>31</day><month>01</month><year>2016</year></pub-date><volume>4</volume><issue>4</issue><fpage>76</fpage><lpage>79</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Martsevich S.Y., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Марцевич С.Ю.</copyright-holder><copyright-holder xml:lang="en">Martsevich S.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/1142">https://www.rpcardio.online/jour/article/view/1142</self-uri><abstract><p>Cardiovascular event risk reduction with medicines is discussed in the article. The role of randomized controlled trials is emphasized for estimation of therapy effects.</p></abstract><trans-abstract xml:lang="ru"><p>Обсуждается возможность воздействия на риск осложнений сердечно-сосудистых заболеваний с помощью лекарственных препаратов. Подчеркивается роль рандомизированных контролируемых исследований в оценке такого воздействия.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>риск сердечно-сосудистых осложнений</kwd><kwd>лекарственные препараты</kwd><kwd>рандомизированные контролируемые исследования.</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiovascular event risk</kwd><kwd>medicines</kwd><kwd>randomized controlled trials</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Veterans Administration Co-operative Study Group. Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. JAMA 1967;202:1028-34.</mixed-citation><mixed-citation xml:lang="en">Veterans Administration Co-operative Study Group. Effects of treatment on morbidity in hypertension. Results in patients with diastolic blood pressures averaging 115 through 129 mm Hg. JAMA 1967;202:1028-34.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Yusuf S., Peto R., Lewis J. et al. Beta-blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis 1985;27:335-71.</mixed-citation><mixed-citation xml:lang="en">Yusuf S., Peto R., Lewis J. et al. Beta-blockade during and after myocardial infarction: an overview of the randomized trials. Prog Cardiovasc Dis 1985;27:335-71.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Есht D.S., Liebeson P.R., Mitchell L.B. et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo: The Cardiac Arrhythmia Supression Trial. N Engl J Med 1991;324(12):781-8.</mixed-citation><mixed-citation xml:lang="en">Есht D.S., Liebeson P.R., Mitchell L.B. et al. Mortality and morbidity in patients receiving encainide, flecainide, or placebo: The Cardiac Arrhythmia Supression Trial. N Engl J Med 1991;324(12):781-8.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">The Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med 2000;342(3):145-53.</mixed-citation><mixed-citation xml:lang="en">The Heart Outcomes Prevention Evaluation Study Investigators. Effects of an angiotensin-converting-enzyme inhibitor, ramipril, on cardiovascular events in high-risk patients. N Engl J Med 2000;342(3):145-53.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">The EURopean trial On reduction of cardiac events with Perindopril in stable coronary Artery disease investigators. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003;362(9386):782–8.</mixed-citation><mixed-citation xml:lang="en">The EURopean trial On reduction of cardiac events with Perindopril in stable coronary Artery disease investigators. Efficacy of perindopril in reduction of cardiovascular events among patients with stable coronary artery disease: randomised, double-blind, placebo-controlled, multicentre trial (the EUROPA study). Lancet 2003;362(9386):782–8.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">The PEACE Trial Investigators. Angiotensin-converting-enzyme inhibition in stable coronary artery disease. N Engl J Med 2004;351(20):2058- 68.</mixed-citation><mixed-citation xml:lang="en">The PEACE Trial Investigators. Angiotensin-converting-enzyme inhibition in stable coronary artery disease. N Engl J Med 2004;351(20):2058- 68.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">The ONTARGET Investigators. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008;358(15):1547-59.</mixed-citation><mixed-citation xml:lang="en">The ONTARGET Investigators. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med 2008;358(15):1547-59.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Wright J.T. Jr, Dunn J.K., Cutler J.A. et al. for the ALLHAT Collaborative Research Group. Outcomes in hypertensive black and nonblack patients treated with chlorthalidone, amlodipine, and lisinopril. JAMA 2005;293(13):1595–608.</mixed-citation><mixed-citation xml:lang="en">Wright J.T. Jr, Dunn J.K., Cutler J.A. et al. for the ALLHAT Collaborative Research Group. Outcomes in hypertensive black and nonblack patients treated with chlorthalidone, amlodipine, and lisinopril. JAMA 2005;293(13):1595–608.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Dahlf B., Sever P.S., Poulter N.R. et al for the ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005;366:895-906.</mixed-citation><mixed-citation xml:lang="en">Dahlf B., Sever P.S., Poulter N.R. et al for the ASCOT Investigators. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet 2005;366:895-906.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Wald N., Law M. A strategy to reduce cardiovascular disease by more than 80%. BMJ 2003;326:1419-25.</mixed-citation><mixed-citation xml:lang="en">Wald N., Law M. A strategy to reduce cardiovascular disease by more than 80%. BMJ 2003;326:1419-25.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Gaede P., Vedel P., Larsen N. et al. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med 2003;348(5):383-93.</mixed-citation><mixed-citation xml:lang="en">Gaede P., Vedel P., Larsen N. et al. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med 2003;348(5):383-93.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Eur Heart J 2007;28(19):2375-414.</mixed-citation><mixed-citation xml:lang="en">European guidelines on cardiovascular disease prevention in clinical practice: executive summary. Eur Heart J 2007;28(19):2375-414.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Марцевич С.Ю. Проблема лечения статинами в России: помогут ли дженерики? Рационал Фармакотер Кардиол 2006;(2):57-60.</mixed-citation><mixed-citation xml:lang="en">Марцевич С.Ю. Проблема лечения статинами в России: помогут ли дженерики? Рационал Фармакотер Кардиол 2006;(2):57-60.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Якусевич В.В. Качественное лекарственное средство: каким оно должно быть. Рационал Фармакотер Кардиол 2006;(4):41-6.</mixed-citation><mixed-citation xml:lang="en">Якусевич В.В. Качественное лекарственное средство: каким оно должно быть. Рационал Фармакотер Кардиол 2006;(4):41-6.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
