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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2008-4-5-67-70</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-1160</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CURRENT QUESTIONS OF CLINICAL PHARMACOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ  ВОПРОСЫ  КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>DOBUTAMINE USAGE IN CARDIOLOGICAL PRACTICE</article-title><trans-title-group xml:lang="ru"><trans-title>ПРИМЕНЕНИЕ ДОБУТАМИНА В КАРДИОЛОГИЧЕСКОЙ ПРАКТИКЕ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гиляров</surname><given-names>М. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Giljarov</surname><given-names>M. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кафедра профилактической и неотложной кардиологии</p></bio><bio xml:lang="en"><p>Chair of preventive and emergency cardiology</p></bio><email xlink:type="simple">gilarov@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московская медицинская академия им. И. М. Сеченова, 119992 Москва, Б. Пироговская ул., д.6</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow Medical Academy named after M.I. Setchenov, Bolshaya Pirogovskaya ul 6, Moscow, 119992 Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2008</year></pub-date><pub-date pub-type="epub"><day>01</day><month>02</month><year>2016</year></pub-date><volume>4</volume><issue>5</issue><fpage>67</fpage><lpage>70</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Giljarov M.Y., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Гиляров М.Ю.</copyright-holder><copyright-holder xml:lang="en">Giljarov M.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/1160">https://www.rpcardio.online/jour/article/view/1160</self-uri><abstract><p>Dobutamine is inotropic drug indicated in systolic dysfunction. Data on dobutamine pharmacology, its effects on hemodynamics, coronary and peripheral blood flow, myocardial electrophysiology are presented. Clinical usage and the main contraindications of dobutamine are discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Добутамин – инотропный агент, применение которого показано в большинстве случаев снижения насосной функции сердца. Представлены данные о фармакологии добутамина, о его влиянии на гемодинамику, коронарный и периферический кровоток, электрофизиологические свойства миокарда. Подробно рассматриваются различные клинические аспекты применения добутамина, основные противопоказания к его назначению.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>добутамин</kwd><kwd>инотропные препараты</kwd><kwd>острая и хроническая сердечная недостаточность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dobutamine</kwd><kwd>inotropic drugs</kwd><kwd>acute and chronic heart failure</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ruffolo R.R. Jr. The mechanism of action of dobutamine. Ann Intern Med 1984;100(2):313-4.</mixed-citation><mixed-citation xml:lang="en">Ruffolo R.R. Jr. The mechanism of action of dobutamine. Ann Intern Med 1984;100(2):313-4.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor D.O. et al. Dobutamine. In: Messerli F. H., editor. 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