rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2016-12-1-66-71rpcardio-1203Research ArticleINNOVATIVE CARDIOLOGYИННОВАЦИОННАЯ КАРДИОЛОГИЯGut microbiota – a new companion on the path of cardiovascular diseases progression: surprising roles of long-time neighborsКИШЕЧНАЯ МИКРОБИОТА – НОВЫЙ СПУТНИК НА МАРШРУТЕ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙ: НЕОЖИДАННЫЕ РОЛИ СТАРЫХ СОСЕДЕЙДрапкинаО. М.DrapkinaO. M.

д.м.н., профессор, первый заместитель директора по научной и лечебной работе ГНИЦ ПМ

drapkina@bk.ruКабуроваА. Н.KaburovaA. N.

клинический ординатор кафедры факультетской терапии ПМГМУ им. И.М. Сеченова

Государственный научно-исследовательский центр профилактической медицины 101990, Москва, Россия, Петроверигский пер., 10 стр.3РоссияState Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 RussiaRussian FederationПервый Московский государственный медицинский университет им. И.М. Сеченова 119991, Москва, ул. Трубецкая, 8, стр. 2РоссияI.M. Sechenov First Moscow State Medical University. Trubetskaya ul. 8-2, Moscow, 119991, RussiaRussian Federation2016090320161216671Copyright © Drapkina O.M., Kaburova A.N., 20162016Драпкина О.М., Кабурова А.Н.Drapkina O.M., Kaburova A.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1203

The last decade is marked by the significant reinterpretation of the gut microbiota contribution to chronic disease progression. The researchers’ careful attention is focused on improving the understanding of the metabolic pathways of two dietary compounds – choline and L-carnitine, which stand at the origins of trimethylamine N-oxide (TMAO) formation. This small molecule of great expectations has gained an impressive appreciation due to its ability to promote atherogenesis, and thus increasing the risk of major adverse cardiovascular events and affecting patients’ prognosis. This paper aims to discuss updated concept of microbiota-dependent cardiometabolic consequences of consumption of food rich in quaternary amines as well as to touch upon the currently existing interventions in TMAO production, their limitations and future scientific directions.

Последнее десятилетие характеризуется значимой переоценкой причастности бактерий кишечника к прогрессированию хронических заболеваний. Пристальное внимание исследователей сконцентрировано на совершенствовании понимания метаболических путей двух компонентов пищи – холина и L-карнитина, которые стоят у истоков формирования триметил-N-оксида (ТМАО). Эта небольшая молекула получила признание в связи с ее способностью влиять на атерогенез, увеличивая, таким образом, риск основных сердечно-сосудистых событий и ухудшая прогноз пациентов. Данная работа нацелена на обcуждение обновленной концепции зависимых от микробиоты кардиометаболических последствий употребления продуктов, богатых четвертичными аминами, а также затрагивает существующие способы влияния на образование ТМАО, их ограничения и направления будущих исследований в этой области.

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The authors declare that there are no conflicts of interest present.