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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2016-12-1-94-100</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-1207</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CURRENT QUESTIONS OF CLINICAL PHARMACOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ  ВОПРОСЫ  КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>Features of pharmacotherapy in the elderly patients. Introduction to the problem</article-title><trans-title-group xml:lang="ru"><trans-title>ОСОБЕННОСТИ ФАРМАКОТЕРАПИИ У ПОЖИЛЫХ ПАЦИЕНТОВ. ВВЕДЕНИЕ В ПРОБЛЕМУ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ушкалова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Ushkalova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор кафедры общей и клинической фармакологии Российского университета дружбы народов</p></bio><email xlink:type="simple">eushk@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ткачева</surname><given-names>О. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Tkacheva</surname><given-names>O. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, директор Российского геронтологического научно-клинического центра</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рунихина</surname><given-names>Н. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Runikhina</surname><given-names>N. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., зам. директора того же центра</p></bio><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чухарева</surname><given-names>Н. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Chukhareva</surname><given-names>N. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>м.н.с. терапевтического отделения Научного центра акушерства, гинекологии и перинатологии им. академика В.И. Кулакова</p></bio><xref ref-type="aff" rid="aff-4"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бевз</surname><given-names>А. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Bevz</surname><given-names>A. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., с.н.с. Российского геронтологического научно-клинического центра</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет дружбы народов. 117198, Москва, ул. Миклухо-Маклая, д. 6</institution><country>Россия</country></aff><aff xml:lang="en"><institution>People's Friendship University of Russia. Miklukho-Maklaya ul. 6, Moscow, 117198 Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Российский геронтологический научно-клинический центр. 129226, Москва, ул. 1-ая Леонова, 16</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Gerontological Research Clinical Center. Leonova Pervaya ul. 16, Moscow, 129226 Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Российский геронтологический научно-клинический центр. 129226, Москва, ул. 1-ая Леонова, 16</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov. Oparina ul. 4, Moscow, 117997 Russia</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-4"><aff xml:lang="ru"><institution>Научный центр акушерства, гинекологии и перинатологии им. академика В.И. Кулакова &#13;
117997 Москва, ул. Опарина, 4</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Center for Obstetrics, Gynecology and Perinatology named after academician V.I. Kulakov. Oparina ul. 4, Moscow, 117997 Russia</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>09</day><month>03</month><year>2016</year></pub-date><volume>12</volume><issue>1</issue><fpage>94</fpage><lpage>100</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Ushkalova E.A., Tkacheva O.N., Runikhina N.K., Chukhareva N.A., Bevz A.Y., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Ушкалова Е.А., Ткачева О.Н., Рунихина Н.К., Чухарева Н.А., Бевз А.Ю.</copyright-holder><copyright-holder xml:lang="en">Ushkalova E.A., Tkacheva O.N., Runikhina N.K., Chukhareva N.A., Bevz A.Y.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/1207">https://www.rpcardio.online/jour/article/view/1207</self-uri><abstract><p>Features of pharmacotherapy in the elderly patients are discussed. Data on the pharmacokinetics and pharmacodynamics, comorbidity, polypragmasy and treatment adherence among patients of this age group are presented.</p></abstract><trans-abstract xml:lang="ru"><p>Обсуждаются особенности фармакотерапии пожилых пациентов. Представлены данные по фармакокинетике и фармакодинамике, коморбидности, полипрагмазии и приверженности лечению среди пациентов данной возрастной категории.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>пожилые пациенты</kwd><kwd>возрастные изменения</kwd><kwd>фармакокинетика</kwd><kwd>фармакодинамика</kwd><kwd>полипрагмазия</kwd><kwd>коморбидность</kwd><kwd>приверженность лечению</kwd></kwd-group><kwd-group xml:lang="en"><kwd>elderly patients</kwd><kwd>age-related changes</kwd><kwd>pharmacokinetics</kwd><kwd>pharmacodynamics</kwd><kwd>comorbidity</kwd><kwd>polypragmasy</kwd><kwd>adherence</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">In Russia the share of the population older than working age exceeded 23% - the Ministry of Labour. Available at: http://www.finmarket.ru/news/3496901. Checked 01/20/2016. In Russian (В России доля населения страны старше трудоспособного возраста превысила 23% - Минтруда. Доступно на: http://www.finmarket.ru/news/3496901. Проверено 20.01.2016).</mixed-citation><mixed-citation xml:lang="en">In Russia the share of the population older than working age exceeded 23% - the Ministry of Labour. Available at: http://www.finmarket.ru/news/3496901. Checked 01/20/2016. In Russian (В России доля населения страны старше трудоспособного возраста превысила 23% - Минтруда. Доступно на: http://www.finmarket.ru/news/3496901. Проверено 20.01.2016).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Pham CB, Dickman RL. Minimizing Adverse Drug Events in Older Patients. Am Fam Physician 2007;76(12):1837-44.</mixed-citation><mixed-citation xml:lang="en">Pham CB, Dickman RL. Minimizing Adverse Drug Events in Older Patients. Am Fam Physician 2007;76(12):1837-44.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Cusack BJ. Pharmacokinetics in older persons. Am J Geriatr Pharmacother 2004;2(4):274-302.</mixed-citation><mixed-citation xml:lang="en">Cusack BJ. Pharmacokinetics in older persons. Am J Geriatr Pharmacother 2004;2(4):274-302.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Maher RL, Hanlon J, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf 2014;13(1):57-65.</mixed-citation><mixed-citation xml:lang="en">Maher RL, Hanlon J, Hajjar ER. Clinical consequences of polypharmacy in elderly. Expert Opin Drug Saf 2014;13(1):57-65.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Charlesworth CJ, Smit E, Lee DS, et al. Polypharmacy Among Adults Aged 65 Years and Older in the</mixed-citation><mixed-citation xml:lang="en">Charlesworth CJ, Smit E, Lee DS, et al. Polypharmacy Among Adults Aged 65 Years and Older in the</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">United States: 1988-2010. J Gerontol A Biol Sci Med Sci 2015;70(8):989-95.</mixed-citation><mixed-citation xml:lang="en">United States: 1988-2010. J Gerontol A Biol Sci Med Sci 2015;70(8):989-95.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Belovol AN Kazakov II Clinical pharmacology in geriatrics. Medix Anti-aging 2012; 1 (25): 50-5. In Russian (Беловол А.Н., Князькова И.И. Клиническая фармакология в гериатрии. Medix Anti-aging 2012; 1(25): 50-5).</mixed-citation><mixed-citation xml:lang="en">Belovol AN Kazakov II Clinical pharmacology in geriatrics. Medix Anti-aging 2012; 1 (25): 50-5. In Russian (Беловол А.Н., Князькова И.И. Клиническая фармакология в гериатрии. Medix Anti-aging 2012; 1(25): 50-5).</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Wong DF, Pearlson GD, Tune LE, et al. Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness. J Cereb Blood Flow Metab 1997;17(3):331-42.</mixed-citation><mixed-citation xml:lang="en">Wong DF, Pearlson GD, Tune LE, et al. Quantification of neuroreceptors in the living human brain: IV. Effect of aging and elevations of D2-like receptors in schizophrenia and bipolar illness. J Cereb Blood Flow Metab 1997;17(3):331-42.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Mattappalil A, Mergenhagen KA. Neurotoxicity with antimicrobials in the elderly: a review. Clin Ther 2014;36(11):1489-1511.e4.</mixed-citation><mixed-citation xml:lang="en">Mattappalil A, Mergenhagen KA. Neurotoxicity with antimicrobials in the elderly: a review. Clin Ther 2014;36(11):1489-1511.e4.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Bressler R, Bahl JJ. Principles of drug therapy for the elderly patient. Mayo Clin Proc 2003;78: 1564-77.</mixed-citation><mixed-citation xml:lang="en">Bressler R, Bahl JJ. Principles of drug therapy for the elderly patient. Mayo Clin Proc 2003;78: 1564-77.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Wooten JM., Pharmacotherapy Considerations in Elderly Adults. South Med J 2012;105(8):437-45.</mixed-citation><mixed-citation xml:lang="en">Wooten JM., Pharmacotherapy Considerations in Elderly Adults. South Med J 2012;105(8):437-45.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Jansen PA, Brouwers JR Clinical pharmacology in old persons. Scientifica (Cairo) 012;2012:723678.</mixed-citation><mixed-citation xml:lang="en">Jansen PA, Brouwers JR Clinical pharmacology in old persons. Scientifica (Cairo) 012;2012:723678.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Mangoni AA, Jackson S D. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol 2004;57(1):6-14.</mixed-citation><mixed-citation xml:lang="en">Mangoni AA, Jackson S D. Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. Br J Clin Pharmacol 2004;57(1):6-14.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">TopinkováE, Baeyens JP, Michel JP, Lang PO. Evidence-based strategies for the optimization of pharmacotherapy in older people. Drugs Aging 2012;29(6):477-94.</mixed-citation><mixed-citation xml:lang="en">TopinkováE, Baeyens JP, Michel JP, Lang PO. Evidence-based strategies for the optimization of pharmacotherapy in older people. Drugs Aging 2012;29(6):477-94.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cherubini A, Oristrell J, Pla X, et al. The persistent exclusion of older subjects from ongoing clinical trials in heart failure. Arch Intern Med 2011; 171 (6): 550-6.</mixed-citation><mixed-citation xml:lang="en">Cherubini A, Oristrell J, Pla X, et al. The persistent exclusion of older subjects from ongoing clinical trials in heart failure. Arch Intern Med 2011; 171 (6): 550-6.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Olshansky SJ, Goldman DP, Zheng Y, Rowe JW. Aging in America in the twenty-first century: demographic forecasts from the MacArthur Foundation Research Network on an aging society. The Milbank Quarterly 2009;87(4):842-62.</mixed-citation><mixed-citation xml:lang="en">Olshansky SJ, Goldman DP, Zheng Y, Rowe JW. Aging in America in the twenty-first century: demographic forecasts from the MacArthur Foundation Research Network on an aging society. The Milbank Quarterly 2009;87(4):842-62.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Qato DM, Alexander GC, Conti RM, et al. Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States. JAMA 2008;300(24):2867-78.</mixed-citation><mixed-citation xml:lang="en">Qato DM, Alexander GC, Conti RM, et al. Use of prescription and over-the-counter medications and dietary supplements among older adults in the United States. JAMA 2008;300(24):2867-78.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Held FP, Blyth F, Gnjidic D, et al. Association Rules Analysis of Comorbidity and Multimorbidity: The</mixed-citation><mixed-citation xml:lang="en">Held FP, Blyth F, Gnjidic D, et al. Association Rules Analysis of Comorbidity and Multimorbidity: The</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Concord Health and Aging in Men Project. J Gerontol A Biol Sci Med Sci 2015 Oct 27. [Epub ahead of print].</mixed-citation><mixed-citation xml:lang="en">Concord Health and Aging in Men Project. J Gerontol A Biol Sci Med Sci 2015 Oct 27. [Epub ahead of print].</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Lazebnyk LB, Konev YV, Drozdov VN, Efremov LI. Polypharmacy: Geriatric aspect of the problem. Consilium-medicum 2007; 12: 29-34. In Russian (Лазебник Л.Б., Конев Ю.В., Дроздов В.Н., Ефремов Л.И. Полипрагмазия: гериатрический аспект проблемы. Consilium-medicum 2007; 12: 29-34).</mixed-citation><mixed-citation xml:lang="en">Lazebnyk LB, Konev YV, Drozdov VN, Efremov LI. Polypharmacy: Geriatric aspect of the problem. Consilium-medicum 2007; 12: 29-34. In Russian (Лазебник Л.Б., Конев Ю.В., Дроздов В.Н., Ефремов Л.И. Полипрагмазия: гериатрический аспект проблемы. Consilium-medicum 2007; 12: 29-34).</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Vetrano DL, Foebel AD, Marengoni A, et al. Chronic diseases and geriatric syndromes: The different weight of comorbidity. Eur J Intern Med 2016;27:62-7.</mixed-citation><mixed-citation xml:lang="en">Vetrano DL, Foebel AD, Marengoni A, et al. Chronic diseases and geriatric syndromes: The different weight of comorbidity. Eur J Intern Med 2016;27:62-7.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Franck L, Molyneux N, Parkinson L. Systematic review of interventions addressing social isolation and depression in aged care clients. Qual Life Res 2015 Dec 8. [Epub ahead of print]</mixed-citation><mixed-citation xml:lang="en">Franck L, Molyneux N, Parkinson L. Systematic review of interventions addressing social isolation and depression in aged care clients. Qual Life Res 2015 Dec 8. [Epub ahead of print]</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Molinari E, Spatola C, Pietrabissa G, et al. The Role of Psychogeriatrics in Healthy Living and Active Ageing. Stud Health Technol Inform 2014;203:122-33.</mixed-citation><mixed-citation xml:lang="en">Molinari E, Spatola C, Pietrabissa G, et al. The Role of Psychogeriatrics in Healthy Living and Active Ageing. Stud Health Technol Inform 2014;203:122-33.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Tjia J, Velten SJ, Parsons C, et al. Studies to reduce unnecessary medication use in frail older adults: a systematic review. Drugs Aging 2013;30:285-307.</mixed-citation><mixed-citation xml:lang="en">Tjia J, Velten SJ, Parsons C, et al. Studies to reduce unnecessary medication use in frail older adults: a systematic review. Drugs Aging 2013;30:285-307.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Rossi MI, Young A, Maher R, et al. Polypharmacy and health beliefs in older outpatients. Am J Geriatr Pharmacother 2007;5:317-23.</mixed-citation><mixed-citation xml:lang="en">Rossi MI, Young A, Maher R, et al. Polypharmacy and health beliefs in older outpatients. Am J Geriatr Pharmacother 2007;5:317-23.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Hajjar E, Hanlon JT, Sloane RJ, et al. Unnecessary drug use in frail older people at hospital discharge. J Am Geriatr Soc 2005;53:1518-23.</mixed-citation><mixed-citation xml:lang="en">Hajjar E, Hanlon JT, Sloane RJ, et al. Unnecessary drug use in frail older people at hospital discharge. J Am Geriatr Soc 2005;53:1518-23.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Steinman MA, Landefeld CS, Rosenthal GE, et al. Polypharmacy and prescribing quality in older people. Am Geriatr Soc 2006;54(10):1516-23.</mixed-citation><mixed-citation xml:lang="en">Steinman MA, Landefeld CS, Rosenthal GE, et al. Polypharmacy and prescribing quality in older people. Am Geriatr Soc 2006;54(10):1516-23.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Nobili A, Licata G, Salerno F, et al. Polypharmacy, length of hospital stay and inpatient mortality among elderly patients in internal medicine wards. The REPOSI study. Eur J Clin Pharmacol 2011;67:507- 19.</mixed-citation><mixed-citation xml:lang="en">Nobili A, Licata G, Salerno F, et al. Polypharmacy, length of hospital stay and inpatient mortality among elderly patients in internal medicine wards. The REPOSI study. Eur J Clin Pharmacol 2011;67:507- 19.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Dwyer L, Han B, Woodwell D, et al. Polypharmacy in nursing home residents in the United States: results of the 2004 National Nursing Home Survey. Am J Geriatr Pharmacother 2009;8:63-72.</mixed-citation><mixed-citation xml:lang="en">Dwyer L, Han B, Woodwell D, et al. Polypharmacy in nursing home residents in the United States: results of the 2004 National Nursing Home Survey. Am J Geriatr Pharmacother 2009;8:63-72.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Bronskill S, Sudeep S, Gill MD, et al. Exploring variation in rates of polypharmacy across long term care homes. JAMDA 2012:309, e15-e21.</mixed-citation><mixed-citation xml:lang="en">Bronskill S, Sudeep S, Gill MD, et al. Exploring variation in rates of polypharmacy across long term care homes. JAMDA 2012:309, e15-e21.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Beijer HJ, de Blaey CJ.Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies. Pharm World Sci 2002; 24(2):46-54.</mixed-citation><mixed-citation xml:lang="en">Beijer HJ, de Blaey CJ.Hospitalisations caused by adverse drug reactions (ADR): a meta-analysis of observational studies. Pharm World Sci 2002; 24(2):46-54.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Lattanzio F, Landi F, Bustacchini S, et al. Geriatric conditions and the risk of adverse drug reactions in older adults: a review. Drug Saf 2012;35 Suppl 1:55-61.</mixed-citation><mixed-citation xml:lang="en">Lattanzio F, Landi F, Bustacchini S, et al. Geriatric conditions and the risk of adverse drug reactions in older adults: a review. Drug Saf 2012;35 Suppl 1:55-61.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Belousov YB, Gurevich KG Clinical pharmacokinetics. The practice of dispensing medication. Moscow: Litterra; 2005. In Russian (Белоусов Ю.Б., Гуревич К.Г. Клиническая фармакокинетика. Практика дозирования лекарств. Москва: Литтерра; 2005).</mixed-citation><mixed-citation xml:lang="en">Belousov YB, Gurevich KG Clinical pharmacokinetics. The practice of dispensing medication. Moscow: Litterra; 2005. In Russian (Белоусов Ю.Б., Гуревич К.Г. Клиническая фармакокинетика. Практика дозирования лекарств. Москва: Литтерра; 2005).</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Kovalenko V., ed. Features of the application of drugs in elderly and senile age. Guidelines for cardiology. Kiev: Morion; 2008. In Russian (Коваленко В.Н., ред. Особенности применения лекарственных средств в пожилом и старческом возрасте. Руководство по кардиологии. Киев: Морион; 2008).</mixed-citation><mixed-citation xml:lang="en">Kovalenko V., ed. Features of the application of drugs in elderly and senile age. Guidelines for cardiology. Kiev: Morion; 2008. In Russian (Коваленко В.Н., ред. Особенности применения лекарственных средств в пожилом и старческом возрасте. Руководство по кардиологии. Киев: Морион; 2008).</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Haynes RB, McDonald H, Garg AX, Montague P. Interventions for helping patients to follow prescriptions for medications. Cochrane Database Syst Rev 2002;(2):CD000011.</mixed-citation><mixed-citation xml:lang="en">Haynes RB, McDonald H, Garg AX, Montague P. Interventions for helping patients to follow prescriptions for medications. Cochrane Database Syst Rev 2002;(2):CD000011.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Bloom BS. Daily regimen and compliance with treatment. BMJ 2001;323(7314):647.</mixed-citation><mixed-citation xml:lang="en">Bloom BS. Daily regimen and compliance with treatment. BMJ 2001;323(7314):647.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Benner JS, Glynn RJ, Mogun H, Neumann PJ, Weinstein MC, Avorn J. Long-term persistence in use of statin therapy in elderly patients. JAMA 2002;288(4):455-61.</mixed-citation><mixed-citation xml:lang="en">Benner JS, Glynn RJ, Mogun H, Neumann PJ, Weinstein MC, Avorn J. Long-term persistence in use of statin therapy in elderly patients. JAMA 2002;288(4):455-61.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Greenberg RN. Overview of patient compliance with medication dosing: a literature review. Clin Ther 1984;6(5):592-9.</mixed-citation><mixed-citation xml:lang="en">Greenberg RN. Overview of patient compliance with medication dosing: a literature review. Clin Ther 1984;6(5):592-9.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther 2001;23(8):1296-310.</mixed-citation><mixed-citation xml:lang="en">Claxton AJ, Cramer J, Pierce C. A systematic review of the associations between dose regimens and medication compliance. Clin Ther 2001;23(8):1296-310.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Stegemann S, Ecker F, Maio M, et al. Geriatric drug therapy: neglecting the inevitable majority. Ageing Res Rev 2010; 9: 384-98.</mixed-citation><mixed-citation xml:lang="en">Stegemann S, Ecker F, Maio M, et al. Geriatric drug therapy: neglecting the inevitable majority. Ageing Res Rev 2010; 9: 384-98.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
