rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2016-12-2-204-209rpcardio-1244Research ArticlePOINT OF VIEWТОЧКА ЗРЕНИЯESTIMATION OF HIGHLY SENSITIVE TROPONIN TESTS IN THE DIAGNOSIS OF ACUTE CORONARY SYNDROMEОЦЕНКА ВЫСОКОЧУВСТВИТЕЛЬНЫХ ТЕСТОВ НА ТРОПОНИН В ДИАГНОСТИКЕ ОСТРОГО КОРОНАРНОГО СИНДРОМАКремневаЛ. В.KremnevaL. V.

Кремнева Людмила Викторовна – доктор медицинских наук, профессор кафедры клинической лабораторной диагностики факультета повышения квалификации и профессиональной переподготовки специалистов ТюмГМУ

KremnevaLV01@gmail.comСуплотовС. Н.SuplotovS. N.

Суплотов Сергей Николаевич – профессор, доктор медицинских наук, заведующий   кафедрой клинической лабораторной диагностики факультета повышения квалификации и профессиональной переподготовки специалистов ТюмГМУ

KremnevaLV01@gmail.comШалаевС. В.ShalaevS. V.

Шалаев Сергей Васильевич – доктор медицинских наук, профессор, зав. кафедрой кардиологии факультета повышения квалификации и профессиональной переподготовки специалистов ТюмГМУ

KremnevaLV01@gmail.comТюменский государственный медицинский университетРоссияTyumen State Medical University, TyumenRussian Federation201605052016122204209Copyright © Kremneva L.V., Suplotov S.N., Shalaev S.V., 20162016Кремнева Л.В., Суплотов С.Н., Шалаев С.В.Kremneva L.V., Suplotov S.N., Shalaev S.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1244

Review is devoted to the value of the use of highly sensitive troponin (hs-cTn) tests in the diagnosis of acute coronary syndrome. The classification of the Tn-tests depending on their sensitivity is presented. The possible reasons of troponins appearance in blood of healthy people are shown. Authors consider a 3-hour algorithm for myocardial infarction (MI) diagnostic, recommended by the expert group in 2012. Study results of 2011-2015 years are presented as the basis for the development of a one-hour MI diagnostic algorithm, recommended by the European Society of Cardiology in 2015. Authors discuss the results of studies showing that modern HS-cTnt tests (together with ECG assessment) are capable to diagnose MI in the early stages. They significantly increase the number of identified MI, especially MI without ST segment elevation, as well as identify the group of patients with subsequent favorable prognosis.

Обзор литературы посвящен значению использования высокочувствительных тестов на тропонин (hs-cTn) в диагностике острого коронарного синдрома. Представлена классификация Tn-тестов  в зависимости  от степени их чувствительности. Приводятся  возможные причины появления тропонина в крови у здоровых лиц. Изложен 3-х часовой алгоритм диагностики инфаркта миокарда (ИМ), рекомендованный группой экспертов в 2012  г. Представлены результаты исследований 2011 – 2015 гг., послужившие основанием для разработки одночасового алгоритма диагностики ИМ, рекомендованного к использованию в клинической практике Европейским обществом кардиологов в 2015 г. Приведены результаты исследований, свидетельствующие, что современные hs-cTn тесты (совместно с оценкой ЭКГ) способны диагностировать ИМ уже на ранних стадиях, значительно увеличивают число выявляемых ИМ, особенно за счет ИМ без подъема сегмента ST, а также идентифицируют группу лиц с последующим благоприятным прогнозом.

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The authors declare that there are no conflicts of interest present.