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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2016-12-3-302-305</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-1273</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NOTES FROM PRACTICE</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ ОПЫТ</subject></subj-group></article-categories><title-group><article-title>CLINICAL CASE OF THROMBOLYTIC THERAPY OF RECURRENT ST-SEGMENT ELEVATION MYOCARDIAL INFARCTION IN PATIENT WITH LONG HISTORY OF ISCHEMIC HEART DISEASE</article-title><trans-title-group xml:lang="ru"><trans-title>КЛИНИЧЕСКИЙ СЛУЧАЙ ТРОМБОЛИТИЧЕСКОЙ ТЕРАПИИ ПОВТОРНОГО ОСТРОГО ИНФАРКТА МИОКАРДА С ПОДЪЕМОМ СЕГМЕНТА ST У БОЛЬНОГО С ДЛИТЕЛЬНЫМ АНАМНЕЗОМ ИШЕМИЧЕСКОЙ БОЛЕЗНИ СЕРДЦА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ватутин</surname><given-names>Н. Т.</given-names></name><name name-style="western" xml:lang="en"><surname>Vatutin</surname><given-names>N. T.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, зав. кафедрой госпитальной терапии ДонНМУ им. М. Горького, зав. отделом кардиологии и кардиохирургии ИНВХ им. В.К. Гусака</p></bio><email xlink:type="simple">kostvalerij@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Костогрыз</surname><given-names>В. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Kostogryz</surname><given-names>V. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-кардиолог отделения неотложной кардиологии и тромболизиса ИНВХ им. В.К. Гусак</p></bio><email xlink:type="simple">kostvalerij@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Костогрыз</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Kostogryz</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-кардиолог Городской больницы №4 г. Донецк</p></bio><email xlink:type="simple">kostvalerij@yandex.ru</email><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Столика</surname><given-names>О. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Stolika</surname><given-names>O. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., зав. отделением неотложной кардиологии и тромболизиса ИНВХ им. В.К. Гусака</p></bio><email xlink:type="simple">kostvalerij@yandex.ru</email><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Институт неотложной и восстановительной хирургии им. В.К. Гусака&#13;
Украина, 283045, Донецк, пр. Ленинский, 47&#13;
Донецкий национальный медицинский университет им. М. Горького&#13;
Украина, 283003, Донецк, пр. Ильича, 16</institution><country>Украина</country></aff><aff xml:lang="en"><institution>Institute of Emergency and Reconstructive Surgery. Leninsky prosp. 47, Donetsk, 283045 Ukraine&#13;
Donetsk State Medical University. Ilyicha prosp. 16, Donetsk, 283003 Ukraine</institution><country>Ukraine</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Институт неотложной и восстановительной хирургии им. В.К. Гусака&#13;
Украина, 283045, Донецк, пр. Ленинский, 47</institution><country>Украина</country></aff><aff xml:lang="en"><institution>Institute of Emergency and Reconstructive Surgery. Leninsky prosp. 47, Donetsk, 283045 Ukraine</institution><country>Ukraine</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Городская больница № 4. Украина, 283015, Донецк, ул. Челюскинцев, 186а</institution><country>Украина</country></aff><aff xml:lang="en"><institution>City hospital number 4. Chelyuskintsev ul. 186a, Donetsk, 283015 Ukraine</institution><country>Ukraine</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2016</year></pub-date><pub-date pub-type="epub"><day>30</day><month>06</month><year>2016</year></pub-date><volume>12</volume><issue>3</issue><fpage>302</fpage><lpage>305</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Vatutin N.T., Kostogryz V.B., Kostogryz A.I., Stolika O.I., 2016</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="ru">Ватутин Н.Т., Костогрыз В.Б., Костогрыз А.И., Столика О.И.</copyright-holder><copyright-holder xml:lang="en">Vatutin N.T., Kostogryz V.B., Kostogryz A.I., Stolika O.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/1273">https://www.rpcardio.online/jour/article/view/1273</self-uri><abstract><p>Presented case report demonstrates the efficacy and safety of hospital use of thrombolytic agent Fortelizin in pharmaco-invasive strategy for the treatment of a patient with acute myocardial infarction and with a long history of ischemic heart disease and long-term dynamics of the verified angiographic progression of coronary atherosclerosis. Hospital thrombolytic therapy with Fortelizin was vital alternative in case of a substantial time delay in mechanical reperfusion of the myocardium.</p></abstract><trans-abstract xml:lang="ru"><p>Приведенный клинический случай показывает эффективность и безопасность госпитального применения тромболитического препарата Фортелизин в рамках фармако-инвазивной стратегии лечения больного острым инфарктом миокарда с длительным анамнезом ишемической болезни сердца и верифицированной ангиографической динамикой многолетнего прогрессирования атеросклероза коронарных артерий. При этом госпитальная тромболитическая терапия Фортелизином оказалась жизненно необходимой альтернативой в случае существенной временной задержки механической реперфузии миокарда. </p></trans-abstract><kwd-group xml:lang="ru"><kwd>фортелизин</kwd><kwd>острый инфаркт миокарда</kwd><kwd>фармакоинвазивная стратегия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Fortelizin</kwd><kwd>acute myocardial infarction</kwd><kwd>pharmacoinvasive strategy</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Antman EM, Braunwald E. ST elevation myocardial infarction: Pathology, Pathophysiology and Clinical Features. In: Libby P, Bonow RO, Mann DL, et al. (Eds). Braunwald’s Heart Disease — A textbook of Cardiovascular Medicine. 8th ed. Philadelphia: Elsevier Saunders; 2008:1210-76.</mixed-citation><mixed-citation xml:lang="en">Antman EM, Braunwald E. 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