rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2016-12-3-331-336rpcardio-1278Research ArticlePOINT OF VIEWТОЧКА ЗРЕНИЯGENETIC PREDICTORS OF ATRIAL FIBRILLATIONГЕНЕТИЧЕСКИЕ ПРЕДИКТОРЫ ФИБРИЛЛЯЦИИ ПРЕДСЕРДИЙКускаеваА. В.KuskaevaA. V.

заочный аспирант, кафедра внутренних болезней № 1 КрасГМУ им. проф. В.Ф. Войно-Ясенецкого

alina_krsk@mail.ruНикулинаС. Ю.NikulinaS. Yu.

д.м.н., профессор, заведующая кафедрой внутренних болезней № 1 КрасГМУ им. проф. В.Ф. Войно-Ясенецкого, проректор по учебной работе КрасГМУ им. проф. В.Ф. Войно-Ясенецкого

alina_krsk@mail.ruЧерноваА. А.ChernovaA. A.

д.м.н., доцент кафедры внутренних болезней № 1 КрасГМУ им. проф. В.Ф. Войно-Ясенецкого, руководитель Российско-итальянской лаборатории медицинской генетики КрасГМУ им. проф. В.Ф. Войно-Ясенецкого

alina_krsk@mail.ruАксютинаН. В.AksyutinaN. V.

д.м.н., доцент кафедры внутренних болезней № 1 КрасГМУ им. проф. В.Ф. Войно-Ясенецкого

alina_krsk@mail.ruКрасноярский государственный медицинский университет имени профессора В.Ф. Войно-Ясенецкого. 660022, Красноярск, ул. Партизана Железняка, 1РоссияKrasnoyarsk State Medical University named after Professor V.F. Voyno-Yasenetsky. Partizana Zheleznyaka ul. 1, Krasnoyarsk, 660022 RussiaRussian Federation201630062016123331336Copyright © Kuskaeva A.V., Nikulina S.Y., Chernova A.A., Aksyutina N.V., 20162016Кускаева А.В., Никулина С.Ю., Чернова А.А., Аксютина Н.В.Kuskaeva A.V., Nikulina S.Y., Chernova A.A., Aksyutina N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1278

Atrial fibrillation (AF) is the most common heart rhythm disturbance. It is believed that the primary form of AF is genetically determined in most cases, but the genetic component cannot be excluded in the secondary form of AF. AF is a heterogeneous disease and many authors proved its relationship with other genetic heart disease. In most cases, certain combinations of polymorphisms of different genes promote the development of AF. The study of genes of renin-angiotensin-aldosterone system (RAAS) is especially important, because the role of this system in AF pathogenesis is currently studding most intensively. These studies are of great practical interest, as associative effect of angiotensin-converting enzyme inhibitors and angiotensin II receptor antagonists in the prevention of AF is revealed. RAAS blockers are able not only to reduce the risk of new-onset AF in hypertensive and normotensive patients but also prevent recurrence of AF. Furthermore, experimental studies showed that RAAS blockers prevent not only the remodeling of the left ventricle, and also the left atrium, pointing to the pathogenesis of AF. So, screening for susceptibility genes and the study of their polymorphism is currently an important focus in the study of AF.

Фибрилляция предсердий (ФП) – наиболее частое нарушение ритма сердца. Считается, что именно первичная форма ФП в большинстве случаев является генетически детерминированной, но и при вторичной форме ФП нельзя исключить генетический компонент. ФП является гетерогенным заболеванием и многими авторами была доказана ее связь с другими генетическими заболеваниями сердца. В большинстве случаев возникновению ФПспособствуют определенные сочетания полиморфизмов различных генов. Особенно актуально изучение генов ренин-ангиотензин-альдостероновой системы (РААС), так как роль этой системы в патогенезе ФП изучается в настоящее время особенно интенсивно. Эти исследования имеют большой практический интерес, поскольку выявлен ассоциативный эффект ингибиторов ангиотен- зинпревращающего фермента и антагонистов рецепторов ангиотензина II в профилактике ФП. Блокаторы РААС способны не только снизить риск развития впервые выявленной ФП у пациентов, как с гипертонической болезнью, так и без нее, но также и предотвратить рецидив ФП. Кроме того, экспериментальные исследования показали, что блокаторы РААС предотвращают ремоделирование не только левого желудочка, но и левого предсердия, что указывает, в том числе, и на патогенез ФП. Поэтому скрининг генов подверженности, изучение их полиморфизма становится в настоящее время важным направлением в исследовании ФП.

 

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The authors declare that there are no conflicts of interest present.