rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2016-12-3-344-350rpcardio-1280Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИMEMBRANE BILE ACID RECEPTOR TGR5 - A NEW TARGET IN THE STUDY OF METABOLIC, INFLAMMATORY AND NEOPLASTIC DISEASESМЕМБРАННЫЙ РЕЦЕПТОР ЖЕЛЧНЫХ КИСЛОТ TGR5 – НОВАЯ МИШЕНЬ В ИЗУЧЕНИИ МЕТАБОЛИЧЕСКИХ, ВОСПАЛИТЕЛЬНЫХ И ОПУХОЛЕВЫХ ЗАБОЛЕВАНИЙДрапкинаО. М.DrapkinaO. M.

д.м.н., профессор, первый зам. директора по научной и лечебной работе ГНИЦ ПМ

drapkina@bk.ruФомичеваЕ. И.FomichevaE. I.

клинический ординатор ГНИЦ ПМ

drapkina@bk.ruГосударственный научно-исследовательский центр профилактической медицины 101990, Москва, Петроверигский пер., 10РоссияState Research Centre for Preventive Medicine. Petroverigsky per. 10, Moscow, 101990 RussiaRussian Federation201630062016123344350Copyright © Drapkina O.M., Fomicheva E.I., 20162016Драпкина О.М., Фомичева Е.И.Drapkina O.M., Fomicheva E.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1280

TGR5 are G-protein-linked, membrane bile acids receptors that widely express in tissues of animals and humans. Namely tissue localization of TGR5 determines biological effects of activation of these receptors. This review focuses on the role of TGR5 as a new pharmacological target for the treatment of patients with metabolic syndrome, diabetes, obesity, atherosclerosis, liver disease and cancer processes.

TGR5 представляют собой G-белок-связанные мембранные рецепторы желчных кислот, широко экспрессируемые в тканях животных и человека. Именно тканевая локализация TGR5 определяет биологические эффекты активации этих рецепторов. Настоящий обзор посвящен роли TGR5 в качестве новой фармакологической мишени при лечении больных с метаболическим синдромом, сахарным диабетом, ожирением, атеросклерозом, заболеваниями печени и онкологическими процессами. 

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The authors declare that there are no conflicts of interest present.