rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2017-13-2-263-269rpcardio-1455Research ArticlePOINT OF VIEWТОЧКА ЗРЕНИЯALDOSTERONE ANTAGONISTS. MODERN VIEWS ON THE MECHANISM OF ACTION AND EFFECTS OF SPIRONOLACTONEАНТАГОНИСТЫ АЛЬДОСТЕРОНА. СОВРЕМЕННЫЕ ПРЕДСТАВЛЕНИЯ О МЕХАНИЗМАХ ДЕЙСТВИЯ И ЭФФЕКТАХ СПИРОНОЛАКТОНАПодзолковВ. И.PodzolkovV. I.

Подзолков Валерий Иванович – доктор медицинских наук, профессор, зав. кафедрой факультетской терапии №2 лечебного факультета, директор Университетской клинической больницей №4

119991, Москва, ул. Трубецкая, 8, стр. 2

Valery I. Podzolkov - MD, PhD, Professor, Head of Chair of Faculty Therapy N2, Director of the University Clinic №4

ДрагомирецкаяН. А.DragomiretskayaN. A.

Драгомирецкая Наталья Александровна – кандидат медицинских наук, доцент кафедры факультетской терапии №2 лечебного факультета

119991, Москва, ул. Трубецкая, 8, стр. 2

galanina_natalia@mail.ruПервый Московский государственный медицинский университет им. И.М. СеченоваРоссияSechenov First Moscow State Medical UniversityRussian Federation201704052017132263269Copyright © Podzolkov V.I., Dragomiretskaya N.A., 20172017Подзолков В.И., Драгомирецкая Н.А.Podzolkov V.I., Dragomiretskaya N.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1455

The importance of renin-angiotensin-aldosterone system in pathogenesis of different clinical conditions is studied well. The key role of aldosterone receptor blockers, particularly spironolactone, in treatment of such conditions as primary hyperaldosteronism, resistant hypertension, edematous syndrome in congestive heart failure, nephrotic syndrome, and portal cirrhosis is considered in the article. Development of ideas about cardio-, vaso- and nephroprotective effects of these drugs is highlighted as well as their influence on patient prognosis.

Значение ренин-ангиотензин-альдостероновой системы в патогенезе различных клинических состояний хорошо изучено. Рассматривается ведущая роль блокаторов альдостероновых рецепторов, в частности, спиронолактона, в лечении больных с первичным гиперальдостеронизмом, резистентной артериальной гипертензией, отечным синдромом в рамках хронической сердечной недостаточности, нефротического синдрома и портального цирроза печени. Освещается развитие представлений о кардио-, вазо- и нефропротективном действии этой группы препаратов и возможностях их влияния на прогноз пациентов.

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The authors declare that there are no conflicts of interest present.