rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2017-13-4-550-557rpcardio-1517Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИCLINICAL ADVANTAGES OF TELMISARTAN: FEATURES OF PHARMACOKINETICS, PHARMACODYNAMICS AND EFFECTS ON THE DAILY BLOOD PRESSURE PROFILEКЛИНИЧЕСКИЕ ПРЕИМУЩЕСТВА ТЕЛМИСАРТАНА: ОСОБЕННОСТИ ФАРМАКОКИНЕТИКИ, ФАРМАКОДИНАМИКИ И ВОЗМОЖНОСТИ КОНТРОЛЯ АРТЕРИАЛЬНОГО ДАВЛЕНИЯ В ТЕЧЕНИЕ СУТОКОстроумоваО. Д.OstroumovaO. D.

д.м.н., профессор, кафедра факультетской терапии и профболезней, 127473, Москва, ул. Делегатская, 20, стр. 1;

кафедра клинической фармакологии и пропедевтики внутренних болезней, 119991, Москва, ул. Трубецкая, 8 стр. 2

MD, PhD, Professor, Chair of Faculty Therapy and Occupational Diseases, Delegatskaya ul. 20-1, Moscow, 127473;

Chair of Clinical Pharmacology and Propaedeutics of Internal Diseases, Trubetskaya ul. 8-2, Moscow, 119991

ostroumova.olga@mail.ruСмолярчукЕ. А.SmolyarchukE. A.

к.м.н., доцент, кафедра клинической фармакологии и пропедевтики внутренних болезней,

119991, Москва, ул. Трубецкая, 8 стр. 2

MD, PhD, Associate Professor, Chair of Clinical Pharmacology and Propaedeutics of Internal Diseases,

Trubetskaya ul. 8-2, Moscow, 119991

БондарецО. В.BondarecO. V.

к.м.н., доцент кафедры факультетской терапии и профболезней,

127473, Москва, ул. Делегатская, 20, стр. 1

MD, PhD, Associate Professor, Chair of Faculty Therapy and Occupational Diseases,

Delegatskaya ul. 20-1, Moscow, 127473

ПавлееваЕ. Е.PaleevaE. E.

к.м.н., ассистент кафедры пропедевтики внутренних болезней и гастроэнтерологии,

127473, Москва, ул. Делегатская, 20, стр. 1

MD, PhD, Assistant, Chair of Faculty Therapy and Occupational Diseases, 

Delegatskaya ul. 20-1, Moscow, 127473

Московский государственный медико-стоматологический университет им. А.И. Евдокимова; Первый Московский государственный медицинский университет имени И.М. СеченоваРоссияA.I. Evdokimov Moscow State University of Medicine and Dentistry; I.M. Sechenov First Moscow State Medical UniversityRussian FederationПервый Московский государственный медицинский университет имени И.М. СеченоваРоссияI.M. Sechenov First Moscow State Medical UniversityRussian FederationМосковский государственный медико-стоматологический университет им. А.И. ЕвдокимоваРоссияA.I. Evdokimov Moscow State University of Medicine and DentistryRussian Federation201703092017134550557Copyright © Ostroumova O.D., Smolyarchuk E.A., Bondarec O.V., Paleeva E.E., 20172017Остроумова О.Д., Смолярчук Е.А., Бондарец О.В., Павлеева Е.Е.Ostroumova O.D., Smolyarchuk E.A., Bondarec O.V., Paleeva E.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1517

The features of the pharmacokinetics of the angiotensin II receptor blocker telmisartan are considered. Thanks to these features it has a number of advantages in comparison with other angiotensin II receptor blockers and antihypertensive drugs from other classes. Particular attention is paid to the long half-life of telmisartan, which retains its effect for more than 24 hours. This is especially important for controlling blood pressure (BP) in the early morning hours. Data from studies demonstrating that excessive BP rises in the early morning hours increase the risk of cardiovascular and cerebrovascular complications are presented. The results of comparative studies of telmisartan using the ambulatory BP monitoring, which testify to its advantages in BP control within 24-hours, are considered.

Рассмотрены особенности фармакокинетики блокатора рецепторов ангиотензина II телмисартана, благодаря которым он имеет ряд преимуществ по сравнению с другими препаратами группы блокаторов рецепторов ангиотензина II и представителями других классов антигипертензивных препаратов. Особое внимание уделено длительному периоду полувыведения телмисартана, который сохраняет его действие значимым более 24 ч, что особо важно для контроля артериального давления (АД) в ранние утренние часы. Представлены данные исследований, демонстрирующих, что избыточные подъемы АД в ранние утренние часы увеличивают риск сердечно-сосудистых и цереброваскулярных осложнений. Рассмотрены результаты сравнительных исследований телмисартана с использованием суточного мониторирования АД, свидетельствующие о его преимуществах в контроле АД в течение суток.

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The authors declare that there are no conflicts of interest present.