rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2017-13-4-558-564rpcardio-1518Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИPROLONGED DUAL ANTIPLATELET THERAPY AFTER MYOCARDIAL INFARCTION: WHAT THE RESULTS OF THE PEGASUS-TIMI 54 TRIAL SHOWПРОДЛЕННАЯ ДВОЙНАЯ АНТИТРОМБОЦИТАРНАЯ ТЕРАПИЯ ПОСЛЕ ИНФАРКТА МИОКАРДА: О ЧЕМ ГОВОРЯТ РЕЗУЛЬТАТЫ ИССЛЕДОВАНИЯ PEGASUS-TIMI 54ЯвеловИ. С.YavelovI. S.

д.м.н., в.н.с., отдел клинической кардиологии и молекулярной генетики,

101000, Москва, Петроверигский пер., 10

MD, PhD, Leading Researcher, Department of Clinical Cardiology and Molecular Genetics,

Petroverigsky per. 10, Moscow, 101990

yavelov@yahoo.comНациональный медицинский исследовательский центр профилактической медициныРоссияNational Medical Research Center for Preventive MedicineRussian Federation201703092017134558564Copyright © Yavelov I.S., 20172017Явелов И.С.Yavelov I.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1518

Prerequisites for the prolonged dual antiplatelet therapy after myocardial infarction are presented. The results of a large randomized placebo-controlled PEGASUS-TIMI 54 trial on the evaluation of efficacy and safety of prolonged use of a combination of acetylsalicylic acid and blocker P2Y12 platelet receptor, ticagrelor, in patients with high risk of thrombotic complications of atherosclerosis with a history of myocardial infarction 1-3 years ago are considered. The contribution of the results of this clinical trial in the modern understanding of the optimal use of antiplatelet agents in patients after myocardial infarction is analyzed.

Представлены предпосылки к продленному использованию двойной антитромбоцитарной терапии после инфаркта миокарда. Рассматриваются результаты крупного рандомизированного плацебо-контролируемого исследования PEGASUS-TIMI 54 по оценке эффективности и безопасности длительного применения сочетания ацетилсалициловой кислоты и блокатора P2Y12 рецептора тромбоцитов тикагрелора у больных с высоким риском тромботических осложнений атеросклероза, перенесших инфаркт миокарда 1-3 года назад. Анализируется вклад, который внесли результаты этого клинического исследования в современные представления об оптимальном использовании антиагрегантов у больных, перенесших инфаркт миокарда.

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The authors declare that there are no conflicts of interest present.