rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2017-13-5-645-650rpcardio-1533Research ArticleASSOCIATED PROBLEMS OF CARDIOLOGYСМЕЖНЫЕ ПРОБЛЕМЫ КАРДИОЛОГИИNON-ALCOHOLIC FATTY LIVER DISEASE AND CARDIOVASCULAR RISK: SCIENTIFIC PROBLEM STATEНЕАЛКОГОЛЬНАЯ ЖИРОВАЯ БОЛЕЗНЬ ПЕЧЕНИ И СЕРДЕЧНО-СОСУДИСТЫЙ РИСК: СОСТОЯНИЕ ПРОБЛЕМЫДрапкинаО. М.DrapkinaO. M.

Драпкина Оксана Михайловна – доктор медицинских наук, профессор, член-корреспондент РАН, директор НМИЦ ПМ.

101990, Москва, Петроверигский пер., 10, стр. 3

Oksana M. Drapkina – MD, PhD, Professor, Corresponding Member of the Russian Academy of Sciences, Director.

Petroverigsky per. 10-3, Moscow, 101990

drapkina@bk.ruЯфароваА. А.YafarovaA. A.

Яфарова Адель Айратовна – студентка 6 курса, Центр инновационных программ «Медицина будущего».

119991, Москва, ул. Трубецкая, 8 стр. 2

Adel A. Yafarova – 6-th Year Student, Center for Innovative Programs "Medicine of the Future".

Trubetskaya ul. 8-2, Moscow, 119991

Национальный медицинский исследовательский центр профилактической медициныРоссияNational Medical Research Center for Preventive MedicineRussian FederationПервый московский государственный медицинский университет имени И.М. СеченоваРоссияI.M. Sechenov First Moscow State Medical UniversityRussian Federation201702112017135645650Copyright © Drapkina O.M., Yafarova A.A., 20172017Драпкина О.М., Яфарова А.А.Drapkina O.M., Yafarova A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1533

Non-alcoholic fatty liver disease (NAFLD) is the most common liver disease worldwide, which is frequently present in patients with atherosclerosis or its complications (myocardial infarction, stroke). Subsequently it was revealed that NAFLD may increase cardiovascular risk independently of traditional cardiovascular risk factors. Possible mechanisms of NAFLD-induced increasing cardiovascular risk are increased oxidative stress, subclinical inflammation, insulin resistance, endothelial dysfunction and deranged аdipocytokines profile. Such risk factors as arterial hypertension, dyslipidemia, obesity, diabetes mellitus type 2 often coexist with NAFLD and contribute to increased cardiovascular risk in these patients. Thus, NAFLD can be considered as an additional risk factor of cardiovascular diseases. In this article we discuss in detail the NAFLD-induced mechanisms which increase the cardiovascular risk regardless of traditional risk factors.

Неалкогольная жировая болезнь печени (НАЖБП) – самое распространенное заболевание печени в мире, особенно часто встречающееся у больных с атеросклерозом или его осложнениями (инфаркт миокарда, инсульт). Впоследствии было выявлено, что НАЖБП повышает  сердечно-сосудистый риск вне зависимости от традиционных факторов риска. Возможными механизмами повышения сердечно-сосудистого риска, индуцированного НАЖБП, служат оксидативный стресс, субклиническое воспаление, инсулинорезистентность, эндотелиальная дисфункция и нарушение секреции адипоцитокинов. Такие факторы риска, как артериальная гипертензия, дислипидемия, ожирение, сахарный диабет 2 типа часто сосуществуют с НАЖБП, способствуя повышению сердечно-сосудистого риска у этих пациентов. Таким образом, с большой долей  вероятности НАЖБП можно  рассматривать как дополнительный фактор  риска сердечно-сосудистых заболеваний. В статье подробно рассмотрены механизмы, индуцированные НАЖБП, которые повышают сердечно-сосудистый риск независимо от традиционных факторов риска.

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The authors declare that there are no conflicts of interest present.