rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2017-13-5-693-698rpcardio-1546Research ArticlePOINT OF VIEWТОЧКА ЗРЕНИЯARTERIAL HYPERTENSION IN THE PRESENCE OF OVERWEIGHT AND OBESITY. THE CAPABILITIES OF AMLODIPINE AND LISINOPRIL COMBINATION. PART 1. FEATURES OF THE DAILY PROFILE OF BLOOD PRESSURE AND HEART DAMAGE AS A TARGET ORGAN IN PATIENTS WITH ARTERIAL HYPERTENSION IN COMBINATION WITH OVERWEIGHT AND OBESITYАРТЕРИАЛЬНАЯ ГИПЕРТОНИЯ В СОЧЕТАНИИ С ИЗБЫТОЧНОЙ МАССОЙ ТЕЛА И ОЖИРЕНИЕМ. ВОЗМОЖНОСТИ КОМБИНАЦИИ АМЛОДИПИНА И ЛИЗИНОПРИЛА. ЧАСТЬ 1. ОСОБЕННОСТИ СУТОЧНОГО ПРОФИЛЯ АРТЕРИАЛЬНОГО ДАВЛЕНИЯ И ПОРАЖЕНИЯ СЕРДЦА КАК ОРГАНА-МИШЕНИ У БОЛЬНЫХ С АРТЕРИАЛЬНОЙ ГИПЕРТОНИЕЙ В СОЧЕТАНИИ С ИЗБЫТОЧНОЙ МАССОЙ ТЕЛА И ОЖИРЕНИЕМОстроумоваО. Д.OstroumovaO. D.

Остроумова Ольга Дмитриевна – доктор медицинских наук, профессор, кафедра  факультетской терапии и профболезней МГМСУ им. А.И. Евдокимова; кафедра  клинической фармакологии и пропедевтики внутренних болезней Первого  МГМУ им. И.М. Сеченова.

127473, Москва, ул. Делегатская, 20, стр. 1; 119991, Москва, ул. Трубецкая, 8 стр. 2

Olga D. Ostroumova – MD, PhD, Professor, Chair of Faculty Therapy and Occupational Diseases, A.I. Evdokimov MSU MD; Chair of Clinical Pharmacology and Propaedeutics of Internal Diseases, I.M. Sechenov FMSMU.

Delegatskaya ul. 20-1, Moscow, 127473; Trubetskaya ul. 8, Moscow, 119991

ostroumova.olga@mail.ruКочетковА. И.KochetkovA. I.

Кочетков Алексей Иванович – ассистент, кафедра факультетской терапии и профболезней.

127473, Москва, ул. Делегатская, 20, стр. 1

Alexey I. Kochetkov – MD, Assistant, Chair of Faculty Therapy and Occupational Diseases.

Delegatskaya ul. 20-1, Moscow, 127473

КопченовИ. И.KopchjonovI. I.

Копченов Иван Иванович – кандидат медицинских наук,  доцент кафедры факультетской терапии и профболезней.

127473, Москва, ул. Делегатская, 20, стр. 1

Ivan I. Kopchjonov – MD, PhD, Associate Professor, Chair of Faculty Therapy and Occupational Diseases.

Delegatskaya ul. 20-1, Moscow, 127473

ФоминаВ. М.FominaV. M.

Фомина Вера Михайловна – кандидат медицинских наук,  доцент кафедры факультетской терапии и профболезней.

127473, Москва, ул. Делегатская, 20, стр. 1

Vera M. Fomina – MD, PhD, Associate Professor, Chair of Faculty Therapy and Occupational Diseases.

Delegatskaya ul. 20-1, Moscow, 127473

Московский государственный медико-стоматологический университет им. А.И. Евдокимова; Первый Московский государственный медицинский университет имени И.М. СеченоваРоссияA.I. Evdokimov Moscow State University of Medicine and Dentistry; I.M. Sechenov First Moscow State Medical UniversityRussian FederationМосковский государственный медико-стоматологический университет им. А.И. ЕвдокимоваРоссияA.I. Evdokimov Moscow State University of Medicine and DentistryRussian Federation201703112017135693698Copyright © Ostroumova O.D., Kochetkov A.I., Kopchjonov I.I., Fomina V.M., 20172017Остроумова О.Д., Кочетков А.И., Копченов И.И., Фомина В.М.Ostroumova O.D., Kochetkov A.I., Kopchjonov I.I., Fomina V.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1546

The main mechanisms by which obesity and overweight exacerbate heart  damage as a target-organ of arterial hypertension (HT), and also increase the risk of cardiovascular complications are discussed. Features  of the daily profile of blood pressure and features of the pathogenesis of HT in obesity are considered. The description of morphofunctional changes of the heart in patients with HT and obesity, in particular the development of left ventricular hypertrophy, is presented separately. Metabolic factors of cardiac remodeling in obesity (peculiarities of adipogenesis, correlation with the volume of epicardial adipose tissue, the role of adiponectin and leptin) are also described. In describing the disorders of elastic properties of the myocardium in obesity and HT, the authors focus on the changes in the global longitudinal systolic and circumferential strains in this category of patients.

В статье представлены основные механизмы, посредством которых ожирение и избыточная масса тела усугубляют поражение сердца как органа-мишени артериальной гипертонии (АГ), а также способствуют повышению риска развития сердечно-сосудистых осложнений. Рассматриваются особенности суточного профиля артериального давления и особенности патогенеза АГ при ожирении. Отдельно представлено описание морфофункциональных изменений в сердце при АГ и ожирении, в частности – развитие гипертрофии левого желудочка. Также описаны  метаболические факторы ремоделирования сердца при ожирении (особенности адипогенеза, взаимосвязь с объемом эпикардиальной жировой ткани, роль адипонектина и лептина). При описании нарушений упруго-эластических свойств миокарда при ожирении и АГ авторы акцентируют внимание на изменениях глобального продольного систолического и циркулярного стрейна у данной категории пациентов.

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The authors declare that there are no conflicts of interest present.