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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2018-14-1-4-11</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-1600</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group></article-categories><title-group><article-title>THIRTY-YEAR CHANGES IN AVERAGE BLOOD LIPIDS LEVELS IN POPULATIONS OF THE RUSSIAN FEDERATION AND THE USA</article-title><trans-title-group xml:lang="ru"><trans-title>ТРИДЦАТИЛЕТНЯЯ ДИНАМИКА СРЕДНИХ ХАРАКТЕРИСТИК ЛИПИДОВ КРОВИ В ПОПУЛЯЦИЯХ РОССИЙСКОЙ ФЕДЕРАЦИИ И США</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шальнова</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Shalnova</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шальнова Светлана Анатольевна – доктор медицинских наук, профессор, руководитель отдела эпидемиологии хронических неинфекционных заболеваний </p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>Svetlana A. Shalnova – MD, PhD, Professor, Head of Department of Epidemiology of Chronic Non-Communicable Diseases</p><p>Petroverigsky per. 10, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Вилков</surname><given-names>В. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Vilkov</surname><given-names>V. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Вилков Владимир Галикович – доктор медицинских наук, ведущий научный сотрудник, отдел эпидемиологии хронических неинфекционных заболеваний </p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>Vladimir G. Vilkov – MD, PhD, Leading Researcher, Department of Epidemiology of Chronic Non-Communicable Diseases</p><p>Petroverigsky per. 10, Moscow, 101990</p></bio><email xlink:type="simple">vilkov_vladimir@list.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Метельская</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Metelskaya</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Метельская Виктория Алексеевна – доктор биологисеских наук, профессор, руководитель отдела изучения биохимических маркеров риска хронических неинфекционных заболеваний </p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>Victoria A. Metelskaya – PhD (in Biology), Professor, Head of Department of Biochemical Markers of Chronic Non-Communicable Diseases</p><p>Petroverigsky per. 10, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баланова</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Balanova</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баланова Юлия Андреевна – кандидат медицинских наук, ведущий научный сотрудник, отдел эпидемиологии хронических неинфекционных заболеваний</p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>Yulia A. Balanova – MD, PhD, Leading Researcher, Department of Epidemiology of Chronic Non-Communicable Diseases</p><p>Petroverigsky per. 10, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Капустина</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kapustina</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Капустина Анна Владимировна – старший научный сотрудник, отдел эпидемиологии хронических неинфекционных заболеваний</p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>Anna V. Kapustina – MD, Senior Researcher, Department of Epidemiology of Chronic Non-Communicable Diseases</p><p>Petroverigsky per. 10, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр профилактической медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Preventive Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>04</day><month>03</month><year>2018</year></pub-date><volume>14</volume><issue>1</issue><fpage>4</fpage><lpage>11</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Shalnova S.A., Vilkov V.G., Metelskaya V.A., Balanova Y.A., Kapustina A.V., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Шальнова С.А., Вилков В.Г., Метельская В.А., Баланова Ю.А., Капустина А.В.</copyright-holder><copyright-holder xml:lang="en">Shalnova S.A., Vilkov V.G., Metelskaya V.A., Balanova Y.A., Kapustina A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/1600">https://www.rpcardio.online/jour/article/view/1600</self-uri><abstract><sec><title> Aim</title><p> Aim. To conduct a comparative study of the changes in blood lipids profiles in populations of the Russian Federation (RF) and the United States of America (USA) in different age and gender groups over the period from 1975 to 2014.</p></sec><sec><title>Material and methods</title><p>Material and methods. Using a secondary analysis of data obtained from the RF population studies carried out in 1975-1982, the multicenter epidemiological study of cardiovascular diseases in different regions of the RF (ESSE-RF), conducted in 2012-2014, as well as the NHANES series of crosssectional surveys in the civilian non-institutionalized population of the USA (NHANES II in 1976-1980 and Continuous NHANES in 2007-2012), we evaluated average lipids in blood tests in men and women of different age groups, with a total number of 48,974 observations.</p></sec><sec><title>Results</title><p>Results. At present, in the RF population, as compared to the USA one, most age groups demonstrate a higher concentration of total cholesterol, i.e. p&lt;0.05 in all groups except for men aged 25-34 years (distinctions are absent) and women aged 25-34 (the concentrations are lower in Russia, p=0.05); a higher concentration of high-density lipoprotein cholesterol, i.e. p&lt;0.005 in all men and p≤0.05 in women younger than 45 years, while in women aged 45-54 years the differences are non-significant; in 55-64-year-old women high-density lipoprotein cholesterol is higher in the USA; the concentration of triglycerides in Russia is lower in comparison with the USA in all age groups of men and women (p&lt;0.01). Over the three decades, the total cholesterol concentration has declined in both countries; the patterns in theUnited States in comparison withRussia are characterized by an increase in the concentration of high-density lipoprotein cholesterol in all age groups and by the absence of a negative trend in triglyceride concentrations.</p></sec><sec><title>Conclusion</title><p>Conclusion. Currently, inRussia, the total cholesterol and low-density lipoprotein cholesterol levels are worse, while triglycerides and partly high-density lipoprotein cholesterol concentrations are better than in theUSA. In general, the thirty-year trends for the aggregate of lipid metabolism parameters are better in theUSA population as compared toRussia. </p></sec></abstract><trans-abstract xml:lang="ru"><sec><title>Цель</title><p>Цель. Провести сравнительное изучение динамики липидных показателей крови в популяциях России и Соединенных Штатов Америки (США) в различных возрастных и половых группах с 1975 по 2014 годы.</p></sec><sec><title> Материал и методы</title><p> Материал и методы. Посредством вторичного анализа данных популяционных российских исследований, выполненных в 1975-1982 гг., многоцентрового наблюдательного исследования «Эпидемиология сердечно-сосудистых заболеваний в регионах Российской Федерации» (ЭССЕ-РФ), выполненного в 2012-2014 гг., а также одномоментных исследований неорганизованной популяции гражданского населения США серии NHANES (NHANES II, 1976-1980 гг. и Continuous NHANES, 2007-2012 гг.) проанализированы средние величины липидных показателей крови у мужчин и женщин различных возрастных групп, общее число наблюдений 48974.</p></sec><sec><title>Результаты</title><p>Результаты. В настоящее время в популяции России в сравнении с США в большинстве возрастных групп выше концентрация общего холестерина – p&lt;0,05 во всех группах, кроме мужчин 25-34 лет (различия отсутствуют) и женщин 25-34 (концентрация ниже в России, p=0,05); выше концентрация холестерина липопротеинов высокой плотности – p&lt;0,005 у всех мужчин и p≤0,05 у женщин моложе 45 лет, у женщин 45-54 лет различия недостоверны, у женщин 55-64 лет холестерин липопротеинов высокой плотности выше в США; концентрация триглицеридов в России ниже в сравнении с США во всех возрастных группах мужчин и женщин (p&lt;0,01). За три десятилетия в обеих странах достигнуто снижение концентрации общего холестерина, динамика в США в сравнении с Россией характеризуется повышением концентрации холестерина липопротеинов высокой плотности во всех возрастных группах и отсутствием негативной динамики концентрации триглицеридов.</p></sec><sec><title>Заключение</title><p>Заключение. В настоящее время в России показатели общего холестерина и холестерина липопротеинов низкой плотности хуже, а триглицеридов и, отчасти, холестерина липопротеинов высокой плотности лучше по сравнению с США. В целом тридцатилетняя динамика по совокупности показателей липидного обмена лучше в популяции США по сравнению с Россией. </p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>дислипидемия</kwd><kwd>факторы риска</kwd><kwd>сердечно-сосудистые заболеваний</kwd></kwd-group><kwd-group xml:lang="en"><kwd>dyslipidemia</kwd><kwd>risk factors</kwd><kwd>cardiovascular diseases</kwd><kwd>NHANES II</kwd><kwd>Continuous NHANES</kwd><kwd>ESSE-RF study</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106(25):3143-421. doi: 01.CIR.0000052861.81153.18.</mixed-citation><mixed-citation xml:lang="en">Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation. 2002;106(25):3143-421. doi: 01.CIR.0000052861.81153.18.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Nelson RH. Hyperlipidemia as a Risk Factor for Cardiovascular Disease. Primary Care. 2013;40(1):195211. doi: 10.1016/j.pop.2012.11.003.</mixed-citation><mixed-citation xml:lang="en">Nelson RH. Hyperlipidemia as a Risk Factor for Cardiovascular Disease. Primary Care. 2013;40(1):195211. doi: 10.1016/j.pop.2012.11.003.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Jain S, Vaishnavi V, Chakraborty BS. The effect of dyslipidemic drugs on mortality: A meta-analysis. Indian Journal of Pharmacology. 2009;41(1):4-8. doi: 10.4103/0253-7613.48878.</mixed-citation><mixed-citation xml:lang="en">Jain S, Vaishnavi V, Chakraborty BS. The effect of dyslipidemic drugs on mortality: A meta-analysis. Indian Journal of Pharmacology. 2009;41(1):4-8. doi: 10.4103/0253-7613.48878.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Cholesterol Treatment Trialists' (CTT) Collaborators. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet. 2012;380(9841):581-90. doi: 10.1016/S0140-6736(12)60367-5.</mixed-citation><mixed-citation xml:lang="en">Cholesterol Treatment Trialists' (CTT) Collaborators. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet. 2012;380(9841):581-90. doi: 10.1016/S0140-6736(12)60367-5.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Grundy SM. Primary prevention of cardiovascular disease with statins: assessing the evidence base behind clinical guidance. Clinical Pharmacist. 2016;8(2). Available at: https://www.pharmaceuticaljournal.com/research/review-article/primary-prevention-of-cardiovascular-disease-with-statins-assessing-the-evidence-base-behind-clinical-guidance/20200568.article. Checked 08.01.2018. doi: 10.1211/CP.2016.20200568.</mixed-citation><mixed-citation xml:lang="en">Grundy SM. Primary prevention of cardiovascular disease with statins: assessing the evidence base behind clinical guidance. Clinical Pharmacist. 2016;8(2). Available at: https://www.pharmaceuticaljournal.com/research/review-article/primary-prevention-of-cardiovascular-disease-with-statins-assessing-the-evidence-base-behind-clinical-guidance/20200568.article. Checked 08.01.2018. doi: 10.1211/CP.2016.20200568.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Konstantinov VV, Zhukovsky GS, Timofeeva TN, et al. Ischemic heart disease, risk factors and mortality of male population: relationship to education. Kardiologiia. 1996;1:37-41. (In Russ.) [Константинов В.В., Жуковский Г.С., Тимофеева Т.Н., и др. Ишемическая болезнь сердца, факторы риска и смертность среди мужского населения в связи с уровнем образования. Кардиология. 1996;1:37-41].</mixed-citation><mixed-citation xml:lang="en">Konstantinov VV, Zhukovsky GS, Timofeeva TN, et al. Ischemic heart disease, risk factors and mortality of male population: relationship to education. Kardiologiia. 1996;1:37-41. (In Russ.) [Константинов В.В., Жуковский Г.С., Тимофеева Т.Н., и др. Ишемическая болезнь сердца, факторы риска и смертность среди мужского населения в связи с уровнем образования. Кардиология. 1996;1:37-41].</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Shalnova SA, Deev AD, Shestov DB, et al. Prognostic assessment of epidemiological characteristics of ischemic heart disease. Kardiologiia. 1997;9:49-54. (In Russ.) [Шальнова С.А., Деев А.Д., Шестов Д.Б. Прогностическая оценка эпидемиологических характеристик ишемической болезни сердца. Кардиология. 1997;9:49-54].</mixed-citation><mixed-citation xml:lang="en">Shalnova SA, Deev AD, Shestov DB, et al. Prognostic assessment of epidemiological characteristics of ischemic heart disease. Kardiologiia. 1997;9:49-54. (In Russ.) [Шальнова С.А., Деев А.Д., Шестов Д.Б. Прогностическая оценка эпидемиологических характеристик ишемической болезни сердца. Кардиология. 1997;9:49-54].</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Epidemiology of cardiovascular diseases in different regions of Russia (ESSE-RF). The rationale for and design of the study. Profilakticheskaya Meditsina. 2013;6:25-34. (In Russ.) [Эпидемиология сердечно-сосудистых заболеваний в различных регионах России (ЭССЕ-РФ). Обоснование и дизайн исследования. Профилактическая Медицина. 2013; 6: 25-34].</mixed-citation><mixed-citation xml:lang="en">Epidemiology of cardiovascular diseases in different regions of Russia (ESSE-RF). The rationale for and design of the study. Profilakticheskaya Meditsina. 2013;6:25-34. (In Russ.) [Эпидемиология сердечно-сосудистых заболеваний в различных регионах России (ЭССЕ-РФ). Обоснование и дизайн исследования. Профилактическая Медицина. 2013; 6: 25-34].</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">National Health and Nutrition Examination Survey: Questionnaires, Datasets, and Related Documentation. Available at: https://wwwn.cdc.gov/nchs/nhanes/Default.aspx. Checked 08.01.2018.</mixed-citation><mixed-citation xml:lang="en">National Health and Nutrition Examination Survey: Questionnaires, Datasets, and Related Documentation. Available at: https://wwwn.cdc.gov/nchs/nhanes/Default.aspx. Checked 08.01.2018.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kuklina EV, Yoon PW, Keenan NL. Trends in high levels of low-density lipoprotein cholesterol in the United States, 1999-2006. JAMA. 2009;302(19):2104-10. doi: 10.1001/jama.2009.1672.</mixed-citation><mixed-citation xml:lang="en">Kuklina EV, Yoon PW, Keenan NL. Trends in high levels of low-density lipoprotein cholesterol in the United States, 1999-2006. JAMA. 2009;302(19):2104-10. doi: 10.1001/jama.2009.1672.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Carroll MD, Lacher DA, Sorlie PD. 30-year trends in serum lipids among United States adults: results from the national health and nutrition examination surveys II, III, and 1999-2006. Am J Cardiol. 2011;107(12):1868-70. doi: 10.1016/j.amjcard.2011.03.047.</mixed-citation><mixed-citation xml:lang="en">Carroll MD, Lacher DA, Sorlie PD. 30-year trends in serum lipids among United States adults: results from the national health and nutrition examination surveys II, III, and 1999-2006. Am J Cardiol. 2011;107(12):1868-70. doi: 10.1016/j.amjcard.2011.03.047.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Carroll MD, Kit BK, Lacher DA, et al. Trends in Lipids and Lipoproteins in US Adults, 1988-2010. JAMA. 2012;308(15):1545-54. doi: 10.1001/jama.2012.13260.</mixed-citation><mixed-citation xml:lang="en">Carroll MD, Kit BK, Lacher DA, et al. Trends in Lipids and Lipoproteins in US Adults, 1988-2010. JAMA. 2012;308(15):1545-54. doi: 10.1001/jama.2012.13260.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Hyre AD, Munter P, Menke A, et al. Trends in ATP-III-defined high blood cholesterol prevalence, awareness, treatment and control among U.S. adults. Ann Epidemiol. 2007;17(7):548-55. doi: 10.1016/j.annepidem.2007.01.03.</mixed-citation><mixed-citation xml:lang="en">Hyre AD, Munter P, Menke A, et al. Trends in ATP-III-defined high blood cholesterol prevalence, awareness, treatment and control among U.S. adults. Ann Epidemiol. 2007;17(7):548-55. doi: 10.1016/j.annepidem.2007.01.03.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Benjamin EJ, Blaha MJ, Chiuve SE, et al. Heart Disease and Stroke Statistics-2017 Update. A Report From the American Heart Association. Circulation. 2017;135(10):e146-e603. doi: 10.1161/CIR.0000000000000485.</mixed-citation><mixed-citation xml:lang="en">Benjamin EJ, Blaha MJ, Chiuve SE, et al. Heart Disease and Stroke Statistics-2017 Update. A Report From the American Heart Association. Circulation. 2017;135(10):e146-e603. doi: 10.1161/CIR.0000000000000485.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Kaufman HW, Blatt AJ, Huang X, et al. Blood Cholesterol Trends 2001-2011 in the United States: Analysis of 105 Million Patient Records. PLoS One. 2013;8(5):e63416. doi: 10.1371/journal.pone.0063416.</mixed-citation><mixed-citation xml:lang="en">Kaufman HW, Blatt AJ, Huang X, et al. Blood Cholesterol Trends 2001-2011 in the United States: Analysis of 105 Million Patient Records. PLoS One. 2013;8(5):e63416. doi: 10.1371/journal.pone.0063416.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
