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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2018-14-2-235-243</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-1654</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PREVENTIVE CARDIOLOGY AND PUBLIC HEALTH</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОФИЛАКТИЧЕСКАЯ КАРДИОЛОГИЯ И ОБЩЕСТВЕННОЕ ЗДОРОВЬЕ</subject></subj-group></article-categories><title-group><article-title>DOCTOR’S ADHERENCE TO RECOMMENDATIONS GOVERNING THE ANTIPLATELET AGENTS USE IN THE CARDIOVASCULAR DISEASES PREVENTION AND TREATMENT</article-title><trans-title-group xml:lang="ru"><trans-title>ПРИВЕРЖЕННОСТЬ ВРАЧЕЙ РЕКОМЕНДАЦИЯМ ПО ПРИМЕНЕНИЮ АНТИАГРЕГАНТОВ В ПРОФИЛАКТИКЕ И ЛЕЧЕНИИ СЕРДЕЧНО-СОСУДИСТЫХ ЗАБОЛЕВАНИЙ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Перепеч</surname><given-names>Н. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Perepech</surname><given-names>N. В.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Никита Борисович Перепеч – доктор медицинских наук, профессор, руководитель научно-клинического и образовательного центра «Кардиология»</p><p>199034, Санкт-Петербург, Университетская наб., 7/9 </p></bio><bio xml:lang="en"><p>Nikita B. Perepech – MD, PhD, Professor, Head of Clinical, Research and Education Center "Cardioilogy"</p><p>Universitetskaya nab. 7-9, St. Petersburg, 199034</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Трегубов</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Tregubov</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Алексей Викторович Трегубов – младший научный сотрудник, научно-клинический и образовательный центр «Кардиология»</p><p>199034, Санкт-Петербург, Университетская наб., 7/9 </p></bio><bio xml:lang="en"><p>Aleksey V. Tregubov – MD, Junior Researcher, Clinical, Research and Education Center "Cardioilogy"</p><p>Universitetskaya nab. 7-9, St. Petersburg, 199034</p></bio><email xlink:type="simple">altregubov@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Санкт-Петербургский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Saint Petersburg State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>01</day><month>05</month><year>2018</year></pub-date><volume>14</volume><issue>2</issue><fpage>235</fpage><lpage>243</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Perepech N.В., Tregubov A.V., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Перепеч Н.Б., Трегубов А.В.</copyright-holder><copyright-holder xml:lang="en">Perepech N.В., Tregubov A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/1654">https://www.rpcardio.online/jour/article/view/1654</self-uri><abstract><sec><title>Aim</title><p>Aim. To study the doctors' opinions on the main aspects of antiplatelet agents use, and to test their knowledge of the basic provisions of the current recommendations on antiplatelet therapy.</p></sec><sec><title>Material and methods</title><p>Material and methods. As a material for the study the results of an anonymous questionnaire in randomly selected doctors were used. The questionnaire contained 11 questions concerning the use of antiplatelet agents for primary and secondary prevention of cardiovascular diseases. 276 questionnaires filled out by 185 therapists, 84 cardiologists and 7 physicians of other therapeutic specialties were analyzed.</p></sec><sec><title>Results</title><p>Results. The results of the study reflect the doctor’s tendency to use acetylsalicylic acid for the primary prevention of cardiovascular diseases, including the patients who do not have indications for its prescribing. 11.6% of respondents never recommend acetylsalicylic acid for primary prevention of cardiovascular diseases. 22.8% of doctors don’t consider it necessary to stop acetylsalicylic acid in patients who do not have indications for such treatment. Therapists demonstrate very low adherence to recommendations which underline the need for a weighted approach to the acetylsalicylic acid prescription. Cardiologists less often than therapists recommend acetylsalicylic acid for the primary prevention of cardiovascular disease in patients with low cardiovascular risk. Less than 30% of therapists and cardiologists tend to prescribe gastroprotectors to patients with aspirin-induced gastropathy. Only 19.6% of the respondents correctly indicated the P2Y12 receptor inhibitor dose to be used in combination with acetylsalicylic acid on the 1st day of acute coronary syndrome depending on planed treatment strategy. 88.4% of doctors consider the use of antiplatelet agents, if the patient with atrial fibrillation and a high risk of thromboembolism refused to take oral anticoagulants. 51.8% of respondents recommend a combination of acetylsalicylic acid and clopidogrel for such patients. Cardiologists are better informed about the recommendations regarding the use of dual antiplatelet therapy and a combination of antiplatelet agents with oral anticoagulants. However, in general, doctors' knowledge of combined antithrombotic therapy is inadequate.</p></sec><sec><title>Conclusion</title><p>Conclusion. The results of the study show that it is necessary to discuss current recommendations on the use of antiplatelet agents for the primary and secondary prevention of cardiovascular diseases in the context of continuous medical education more actively.</p></sec></abstract><trans-abstract xml:lang="ru"><sec><title>Цель</title><p>Цель. Изучить представления врачей об основных аспектах применения антиагрегантов, и проверка знания базовых положений действующих рекомендаций, регламентирующих их применение.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Материалом для исследования послужили данные, полученные в ходе анонимного анкетирования случайной выборки врачей. Анкета содержала 11 вопросов, касающихся применения антиагрегантов для первичной и вторичной профилактики сердечно-сосудистых заболеваний, с готовыми вариантами ответов. В исследование было включено 276 анкет, заполненных 185 терапевтами, 84 кардиологами и 7 врачами других терапевтических специальностей.</p></sec><sec><title>Результаты</title><p>Результаты. Данные, полученные в ходе исследования, отражают склонность врачей использовать ацетилсалициловую кислоту в качестве средства первичной профилактики сердечно-сосудистых заболеваний, в том числе, и у пациентов, не имеющих показаний к ее применению. Лишь 11,6% респондентов никогда не рекомендуют ацетилсалициловую кислоту для первичной профилактики сердечно-сосудистых заболеваний. 22,8% врачей не считают обязательным прекращение приема ацетилсалициловой кислоты у пациентов, не имеющих показаний к такому лечению. Для терапевтов характерна крайне низкая степень приверженности рекомендациям, указывающим на необходимость взвешенного подхода к применению ацетилсалициловой кислоты. Кардиологи реже терапевтов рекомендуют применять ацетилсалициловую кислоту для первичной профилактики сердечно-сосудистых заболеваний у пациентов с невысоким кардиоваскулярным риском. Менее 30% терапевтов и кардиологов склонны назначать гастропротекторы пациентам с аспирин-индуцированной гастропатией. Лишь 19,6% респондентов верно указали дозу ингибитора P2Y12 рецепторов, которая должна быть назначена пациенту с острым коронарным синдромом в комбинации с ацетилсалициловой кислотой в 1-е сут заболевания с учетом стратегии лечения. В случае отказа пациента с фибрилляцией предсердий и высоким риском тромбоэмболии от приема пероральных антикоагулянтов 88,4% врачей считают возможным применение антиагрегантов. 51,8% респондентов рекомендуют лечение таких больных комбинацией ацетилсалициловой кислоты и клопидогрела. Кардиологи лучше терапевтов осведомлены о положениях рекомендаций, касающихся применения двойной антиагрегантной терапии и комбинации антиагрегантов с пероральными антикоагулянтами, однако в целом знания врачей о комбинированной антитромботической терапии являются недостаточными.</p></sec><sec><title>Заключение</title><p>Заключение. Результаты анкетирования свидетельствуют о необходимости более активной работы по разъяснению положений действующих рекомендаций, касающихся применения антиагрегантов c целью первичной и вторичной профилактики сердечно-сосудистых заболеваний, в рамках системы непрерывного медицинского образования.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>знания врачей</kwd><kwd>антиагреганты</kwd><kwd>сердечно-сосудистые заболевания</kwd><kwd>первичная профилактика сердечно-сосудистых заболеваний</kwd><kwd>вторичная профилактика сердечно-сосудистых заболеваний</kwd></kwd-group><kwd-group xml:lang="en"><kwd>knowledge of doctors</kwd><kwd>antiplatelet agents</kwd><kwd>cardiovascular diseases</kwd><kwd>primary prevention of cardiovascular diseases</kwd><kwd>secondary prevention of cardiovascular diseases</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Попова Л.В., Бокарев И.Н. 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