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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2015-11-4-404-412</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-167</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>INNOVATIVE CARDIOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ИННОВАЦИОННАЯ КАРДИОЛОГИЯ</subject></subj-group></article-categories><title-group><article-title>INNOVATIVE TECHNOLOGIES IN CARDIOLOGY: FROM SURPRISE TO HABIT OR FORGETFULNESS</article-title><trans-title-group xml:lang="ru"><trans-title>ИННОВАЦИОННЫЕ ТЕХНОЛОГИИ В КАРДИОЛОГИИ: ОТ УДИВЛЕНИЯ К ПРИВЫЧКЕ ИЛИ ЗАБВЕНИЮ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гиляревский</surname><given-names>С. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Gilyarevskiy</surname><given-names>S. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>123995, Москва, Баррикадная, 2/1</p></bio><bio xml:lang="en"><p>Barricadnaya ul. 2/1, Moscow, 123995 Russia</p></bio><email xlink:type="simple">sgilarevsky@rambler.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Голшмид</surname><given-names>М. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Golshmid</surname><given-names>M. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>123995, Москва, Баррикадная, 2/1</p></bio><bio xml:lang="en"><p>Barricadnaya ul. 2/1, Moscow, 123995 Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кузьмина</surname><given-names>И. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Kuz'mina</surname><given-names>I. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>129010 Москва, Большая Сухаревская пл., д. 3</p></bio><bio xml:lang="en"><p>Bolshaya Sukharevskaya pl. 3, Moscow, 129010 Russia</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российская медицинская академия последипломного образования</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Postgraduate Education</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Научно-исследовательский институт скорой помощи им. Н.В. Склифосовского</institution><country>Россия</country></aff><aff xml:lang="en"><institution>N.V. Sklifosovsky Research Institute of Emergency Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>23</day><month>09</month><year>2015</year></pub-date><volume>11</volume><issue>4</issue><fpage>404</fpage><lpage>412</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Gilyarevskiy S.R., Golshmid M.V., Kuz'mina I.M., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Гиляревский С.Р., Голшмид М.В., Кузьмина И.М.</copyright-holder><copyright-holder xml:lang="en">Gilyarevskiy S.R., Golshmid M.V., Kuz'mina I.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/167">https://www.rpcardio.online/jour/article/view/167</self-uri><abstract><p>Change of the status of innovative technologies depending on the received evidences is considered. Examples reflecting the initiation of interest in the new technology of treatment, the transition from innovation to standard therapies, as well as the weakening of interest in the previously introduced technology due to disappointing results of clinical trials on evaluation of its effectiveness are presented.</p></abstract><trans-abstract xml:lang="ru"><p>Рассматривается изменение «статуса» инновационных технологий в зависимости от полученных доказательств. Представлены примеры, отражающие зарождение интереса в новой технологии лечения, переход из инновационных в стандартные методы лечения, а также ослабление интереса к ранее внедренной технологии в связи с разочаровывающими результатами клинического исследования по оценке его эффективности.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>инновационная технология</kwd><kwd>имплантация альгинатного гидрогеля в левый желудочек</kwd><kwd>окклюзия ушка левого предсердия</kwd><kwd>имплантация фильтра в нижнюю полую вену</kwd></kwd-group><kwd-group xml:lang="en"><kwd>innovative technology</kwd><kwd>the alginate hydrogel implant</kwd><kwd>the left atrial appendage occlusion</kwd><kwd>the inferior vena cava filter</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Anker S.D., Coats A.J., Cristian G., et al. A prospective comparison of alginate-hydrogel with standard medical therapy to determine impact on functional capacity and clinical outcomes in patients with advanced heart failure (AUGMENT-HF trial). Eur Heart J 2015 Jun 16. [Epub ahead of print]</mixed-citation><mixed-citation xml:lang="en">Anker S.D., Coats A.J., Cristian G., et al. A prospective comparison of alginate-hydrogel with standard medical therapy to determine impact on functional capacity and clinical outcomes in patients with advanced heart failure (AUGMENT-HF trial). Eur Heart J 2015 Jun 16. [Epub ahead of print]</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Holmes D.R., Reddy V.Y., Turi Z.G., et al. Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation, a randomized non-inferiority trial. Lancet 2009;374:534-42.</mixed-citation><mixed-citation xml:lang="en">Holmes D.R., Reddy V.Y., Turi Z.G., et al. Percutaneous closure of the left atrial appendage versus warfarin therapy for prevention of stroke in patients with atrial fibrillation, a randomized non-inferiority trial. Lancet 2009;374:534-42.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Reddy V.Y., Doshi S.K., Sievert H., et al. Percutaneous left atrial appendage closure for stroke prophylaxis in patients with atrial fibrillation: 2.3 year follow-up of the PROTECT AF (WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients with Atrial Fibrillation) trial. Circulation 2013;127:720-9.</mixed-citation><mixed-citation xml:lang="en">Reddy V.Y., Doshi S.K., Sievert H., et al. Percutaneous left atrial appendage closure for stroke prophylaxis in patients with atrial fibrillation: 2.3 year follow-up of the PROTECT AF (WATCHMAN Left Atrial Appendage System for Embolic Protection in Patients with Atrial Fibrillation) trial. Circulation 2013;127:720-9.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Reddy V.Y., Holmes D., Doshi S.K., et al. Safety of percutaneous left atrial appendage closure: results from PROTECT AF and the Continued Access Registry. Circulation 2011;123:417-24.</mixed-citation><mixed-citation xml:lang="en">Reddy V.Y., Holmes D., Doshi S.K., et al. Safety of percutaneous left atrial appendage closure: results from PROTECT AF and the Continued Access Registry. Circulation 2011;123:417-24.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Holmes D.R., Kar S., Price M.J., et al. Prospective randomized evaluation for the WATCHMAN left atrial appendage closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial. J Am Coll Cardiol 2014;64:1-12.</mixed-citation><mixed-citation xml:lang="en">Holmes D.R., Kar S., Price M.J., et al. Prospective randomized evaluation for the WATCHMAN left atrial appendage closure device in patients with atrial fibrillation versus long-term warfarin therapy: the PREVAIL trial. J Am Coll Cardiol 2014;64:1-12.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Reddy V.Y., Sievert H., Halperin J., et al. Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial. JAMA 2014;312:1988-98.</mixed-citation><mixed-citation xml:lang="en">Reddy V.Y., Sievert H., Halperin J., et al. Percutaneous left atrial appendage closure vs warfarin for atrial fibrillation: a randomized clinical trial. JAMA 2014;312:1988-98.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Gangireddy S.R., Halperin J.L., Fuster V., Reddy V.Y. Percutaneous left atrial appendage closure for stroke prevention in patients with atrial fibrillation: an assessment of net clinical benefit. Eur Heart J 2012;33:2700-8.</mixed-citation><mixed-citation xml:lang="en">Gangireddy S.R., Halperin J.L., Fuster V., Reddy V.Y. Percutaneous left atrial appendage closure for stroke prevention in patients with atrial fibrillation: an assessment of net clinical benefit. Eur Heart J 2012;33:2700-8.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Blackshear J.L., Odell J.A. Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation. Ann Thorac Surg 1996;61:755-9.</mixed-citation><mixed-citation xml:lang="en">Blackshear J.L., Odell J.A. Appendage obliteration to reduce stroke in cardiac surgical patients with atrial fibrillation. Ann Thorac Surg 1996;61:755-9.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Reddy V.Y., Mobius-Winkler S., Miller M.A., et al. Left atrial appendage closure with the WATCHMAN device in patients with a contraindication for oral anticoagulation: the ASAP study (ASA Plavix Feasibility Study with WATCHMAN Left Atrial Appendage Closure Technology). J Am Coll Cardiol 2013;61:2551-6.</mixed-citation><mixed-citation xml:lang="en">Reddy V.Y., Mobius-Winkler S., Miller M.A., et al. Left atrial appendage closure with the WATCHMAN device in patients with a contraindication for oral anticoagulation: the ASAP study (ASA Plavix Feasibility Study with WATCHMAN Left Atrial Appendage Closure Technology). J Am Coll Cardiol 2013;61:2551-6.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Fountain R.B., Holmes D.R., Chandrasekaran K., et al. The PROTECT AF (WATCHMAN left atrial appendage system for embolic PROTECTion in patients with atrial fibrillation) trial. Am Heart J 2006;15:956-61.</mixed-citation><mixed-citation xml:lang="en">Fountain R.B., Holmes D.R., Chandrasekaran K., et al. The PROTECT AF (WATCHMAN left atrial appendage system for embolic PROTECTion in patients with atrial fibrillation) trial. Am Heart J 2006;15:956-61.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Lewalter T., Kanagaratnam P., Schmidt B., et al. Ischaemic stroke prevention in patients with atrial fibrillation and high bleeding risk: opportunities and challenges for percutaneous left atrial appendage occlusion. Europace 2014;16:626-30.</mixed-citation><mixed-citation xml:lang="en">Lewalter T., Kanagaratnam P., Schmidt B., et al. Ischaemic stroke prevention in patients with atrial fibrillation and high bleeding risk: opportunities and challenges for percutaneous left atrial appendage occlusion. Europace 2014;16:626-30.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Bajaj N.S., Parashar A., Agarwal S., et al. Percutaneous left atrial appendage occlusion for stroke prophylaxis in nonvalvular atrial fibrillation: a systemic review and analysis of observational studies. J Am Coll Caridol Intv 2014;7: 296-304.</mixed-citation><mixed-citation xml:lang="en">Bajaj N.S., Parashar A., Agarwal S., et al. Percutaneous left atrial appendage occlusion for stroke prophylaxis in nonvalvular atrial fibrillation: a systemic review and analysis of observational studies. J Am Coll Caridol Intv 2014;7: 296-304.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Holmes D.R. Jr, Doshi S.K., Kar S., et al. Left Atrial Appendage Closure as an Alternative to Warfarin for Stroke Prevention in Atrial Fibrillation: A Patient-Level Meta-Analysis. J Am Coll Cardiol 2015 ;65:2614-23.</mixed-citation><mixed-citation xml:lang="en">Holmes D.R. Jr, Doshi S.K., Kar S., et al. Left Atrial Appendage Closure as an Alternative to Warfarin for Stroke Prevention in Atrial Fibrillation: A Patient-Level Meta-Analysis. J Am Coll Cardiol 2015 ;65:2614-23.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Mismetti P., Laporte S., Pellerin O., et al. Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial. JAMA 2015;313:1627-35.</mixed-citation><mixed-citation xml:lang="en">Mismetti P., Laporte S., Pellerin O., et al. Effect of a retrievable inferior vena cava filter plus anticoagulation vs anticoagulation alone on risk of recurrent pulmonary embolism: a randomized clinical trial. JAMA 2015;313:1627-35.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Athanasoulis C.A., Kaufman J.A., Halpern E.F., et al. Inferior vena caval filters: review of a 26-year single-center clinical experience. Radiology 2000;216:54-66.</mixed-citation><mixed-citation xml:lang="en">Athanasoulis C.A., Kaufman J.A., Halpern E.F., et al. Inferior vena caval filters: review of a 26-year single-center clinical experience. Radiology 2000;216:54-66.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Stein P.D., Kayali F., Olson R.E. Twenty-one-year trends in the use of inferior vena cava filters. Arch Intern Med 2004;164:1541-5.</mixed-citation><mixed-citation xml:lang="en">Stein P.D., Kayali F., Olson R.E. Twenty-one-year trends in the use of inferior vena cava filters. Arch Intern Med 2004;164:1541-5.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Hammond C.J., Bakshi D.R., Currie R.J., et al. Audit of the use of IVC filters in the United Kingdom: experience from 3 centres over 12 years. Clin Radiol 2009;64:502-10.</mixed-citation><mixed-citation xml:lang="en">Hammond C.J., Bakshi D.R., Currie R.J., et al. Audit of the use of IVC filters in the United Kingdom: experience from 3 centres over 12 years. Clin Radiol 2009;64:502-10.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Stein P.D., Matta F., Hull R.D. Increasing use of vena cava filters for prevention of pulmonary embolism. Am J Med 2011;124:655-61.</mixed-citation><mixed-citation xml:lang="en">Stein P.D., Matta F., Hull R.D. Increasing use of vena cava filters for prevention of pulmonary embolism. Am J Med 2011;124:655-61.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Spencer F.A., Bates S.M., Goldberg R.J., et al. A population-based study of inferior vena cava filters in patients with acute venous thromboembolism. Arch Intern Med 2010;170:1456-62.</mixed-citation><mixed-citation xml:lang="en">Spencer F.A., Bates S.M., Goldberg R.J., et al. A population-based study of inferior vena cava filters in patients with acute venous thromboembolism. Arch Intern Med 2010;170:1456-62.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Kearon C., Akl E.A., Comerota A.J., et al.; American College of Chest Physicians. Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines [published correction appears in Chest 2012;142:1698-1704]. Chest 2012;141(2 suppl):e419S-494S.</mixed-citation><mixed-citation xml:lang="en">Kearon C., Akl E.A., Comerota A.J., et al.; American College of Chest Physicians. Antithrombotic therapy for VTE disease: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines [published correction appears in Chest 2012;142:1698-1704]. Chest 2012;141(2 suppl):e419S-494S.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Torbicki A., Perrier A., Konstantinides S., et al.; ESC Committee for Practice Guidelines (CPG). Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur Heart J 2008;29:2276-315.</mixed-citation><mixed-citation xml:lang="en">Torbicki A., Perrier A., Konstantinides S., et al.; ESC Committee for Practice Guidelines (CPG). Guidelines on the diagnosis and management of acute pulmonary embolism: the Task Force for the Diagnosis and Management of Acute Pulmonary Embolism of the European Society of Cardiology (ESC). Eur Heart J 2008;29:2276-315.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Kaufman J.A., Kinney T.B., Streiff M.B., et al. Guidelines for the use of retrievable and convertible vena cava filters: report from the Society of Interventional Radiology multidisciplinary consensus conference. J Vasc Interv Radiol 2006;17:449-59.</mixed-citation><mixed-citation xml:lang="en">Kaufman J.A., Kinney T.B., Streiff M.B., et al. Guidelines for the use of retrievable and convertible vena cava filters: report from the Society of Interventional Radiology multidisciplinary consensus conference. J Vasc Interv Radiol 2006;17:449-59.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Caplin D.M., Nikolic B., Kalva S.P., et al.; Society of Interventional Radiology Standards of Practice Committee. Quality improvement guidelines for the performance of inferior vena cava filter placement for the prevention of pulmonary embolism. J Vasc Interv Radiol 2011;22:1499-506.</mixed-citation><mixed-citation xml:lang="en">Caplin D.M., Nikolic B., Kalva S.P., et al.; Society of Interventional Radiology Standards of Practice Committee. Quality improvement guidelines for the performance of inferior vena cava filter placement for the prevention of pulmonary embolism. J Vasc Interv Radiol 2011;22:1499-506.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Jaff M.R., McMurtry M.S., Archer S.L., et al.; American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; American Heart Association Council on Peripheral Vascular Disease; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation 2011;123:1788-830.</mixed-citation><mixed-citation xml:lang="en">Jaff M.R., McMurtry M.S., Archer S.L., et al.; American Heart Association Council on Cardiopulmonary, Critical Care, Perioperative and Resuscitation; American Heart Association Council on Peripheral Vascular Disease; American Heart Association Council on Arteriosclerosis, Thrombosis and Vascular Biology. Management of massive and submassive pulmonary embolism, iliofemoral deep vein thrombosis, and chronic thromboembolic pulmonary hypertension: a scientific statement from the American Heart Association. Circulation 2011;123:1788-830.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Decousus H., Leizorovicz A., Parent F., et al. A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep vein thrombosis: Pré vention du Risque d’Embolie Pulmonaire par Interruption Cave Study Group. N Engl J Med 1998;338:409-15.</mixed-citation><mixed-citation xml:lang="en">Decousus H., Leizorovicz A., Parent F., et al. A clinical trial of vena caval filters in the prevention of pulmonary embolism in patients with proximal deep vein thrombosis: Pré vention du Risque d’Embolie Pulmonaire par Interruption Cave Study Group. N Engl J Med 1998;338:409-15.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">PREPIC Study Group. Eight-year follow-up of patients with permanent vena cava filters in the prevention of pulmonary embolism: the PREPIC (Prevention du Risque d’Embolie Pulmonaire par Interruption Cave) randomized study. Circulation 2005;112:416-22.</mixed-citation><mixed-citation xml:lang="en">PREPIC Study Group. Eight-year follow-up of patients with permanent vena cava filters in the prevention of pulmonary embolism: the PREPIC (Prevention du Risque d’Embolie Pulmonaire par Interruption Cave) randomized study. Circulation 2005;112:416-22.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Ansell J. Vena cava filters: do we know all that we need to know? Circulation 2005;112:298-9.</mixed-citation><mixed-citation xml:lang="en">Ansell J. Vena cava filters: do we know all that we need to know? Circulation 2005;112:298-9.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
