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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2018-14-4-605-611</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-1732</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group></article-categories><title-group><article-title>Atrial Fibrillation and Ventricular Arrhythmias in ST Segment Elevation Myocardial Infarction: Possibilities of Pharmacotherapy and Non-Pharmacological Treatment</article-title><trans-title-group xml:lang="ru"><trans-title>Фибрилляция предсердий и желудочковые аритмии при инфаркте миокарда с подъемом сегмента ST: возможности фармакотерапии и немедикаментозного лечения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бунин</surname><given-names>Ю. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Bunin</surname><given-names>Yu. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бунин Юрий Андреевич – доктор медицинских наук, профессор, кафедра кардиологии </p><p>123995, Москва, ул. Баррикадная, 2/1</p></bio><bio xml:lang="en"><p>Yuri A. Bunin – MD, PhD, Professor, Chair of Cardiology</p><p>Barrikadnaya ul. 2/1, Moscow, 123995</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Миклишанская</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Miklisanskaya</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Миклишанская Софья Владимировна – кандидат медицинских наук, ассистент, кафедра кардиологии</p><p>123995, Москва, ул. Баррикадная, 2/1</p></bio><bio xml:lang="en"><p>Sofya V. Miklisanskaya – MD, PhD, Assistant, Chair of Cardiology</p><p>Barrikadnaya ul. 2/1, Moscow, 123995</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чигинева</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Chigineva</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Чигинева Виктория Васильевна – кандидат медицинских наук, доцент, кафедра кардиологии</p><p>123995, Москва, ул. Баррикадная, 2/1</p></bio><bio xml:lang="en"><p>Victoria V. Chigineva – MD, PhD, Associate Professor, Chair of Cardiology</p><p>Barrikadnaya ul. 2/1, Moscow, 123995</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Золозова</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Zolozova</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Золозова Елена Александровна – кандидат медицинских наук, доцент, кафедра кардиологии</p><p>123995, Москва, ул. Баррикадная, 2/1</p></bio><bio xml:lang="en"><p>Elena A. Zolozova – MD, PhD, Associate Professor, Chair of Cardiology</p><p>Barrikadnaya ul. 2/1, Moscow, 123995</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российская медицинская академия непрерывного профессионального образования</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Russian Medical Academy of Continuous Professional Education</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>04</day><month>09</month><year>2018</year></pub-date><volume>14</volume><issue>4</issue><fpage>605</fpage><lpage>611</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Bunin Y.A., Miklisanskaya S.A., Chigineva V.V., Zolozova E.A., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Бунин Ю.А., Миклишанская С.В., Чигинева В.В., Золозова Е.А.</copyright-holder><copyright-holder xml:lang="en">Bunin Y.A., Miklisanskaya S.A., Chigineva V.V., Zolozova E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/1732">https://www.rpcardio.online/jour/article/view/1732</self-uri><abstract><p>Atrial fibrillation (AF) is the most common tachyarrhythmia complicating ST segment elevation myocardial infarction (STEMI), while ventricular arrhythmias (VA) can, not only be accompanied by a hemodynamic disorder, but in some cases, worsen its prognosis. The article presents a modern view on risk factors for development of AF (elderly age, left ventricle systolic dysfunction, heart failure, etc.), strategy and tactics of AF treatment in patients with STEMI, the indications for its pharmacological cardioversion and electro-impulse therapy. It is shown that I.V. administration of betablockers and in some cases amiodarone for reducing the frequency of ventricular contractions is advisable. Features and argumentative issues of triple antithrombotic therapy in patients with AF with STEMI, the possibilities and indications for the use of double antithrombotic therapy instead of triple one are described. Clinical significance and peculiarities of treatment of various types of VA have been determined, the role of myocardial revascularization, radiofrequency catheter ablation, normalization of electrolyte imbalance, use of beta-blockers and amiodarone in the prevention and therapy of lifethreatening ventricular arrhythmias has been emphasized. The irrationality, and sometimes the risk of carrying out prophylactic antiarrhythmic therapy for AF and VA in the acute stage of STEMI, as well as the role of the implantable cardioverter-defibrillator in primary prevention of death in certain groups of patients with low left ventricle ejection fraction after myocardial infarction was noted. The value of various antiarrhythmic drugs in their effect on the improvement of prognosis in patients after STEMI is estimated. The material is presented based on modern recommendations for the treatment of patients with STEMI, therapy of AF and VA, prevention of sudden cardiac death, as well as data from several controlled studies and own clinical experience of pharmacotherapy of arrhythmias.</p></abstract><trans-abstract xml:lang="ru"><p>Фибрилляция предсердий (ФП) – самая частая тахиаритмия, осложняющая течение инфаркта миокарда с подъемом сегмента ST (ИМпST), в то же время желудочковые аритмии (ЖА) могут не только сопровождаться нарушением гемодинамики, но и в ряде случаев ухудшать его прогноз. В статье представлен современный взгляд на факторы риска развития (пожилой возраст, систолическая дисфункция левого желудочка, сердечная недостаточность и др), стратегию и тактику лечения ФП у больных ИМпST, уточнены показания для ее фармакологической кардиоверсии и электроимпульсной терапии. Показана целесообразность в\в введения бета-адреноблокаторов, а в ряде случаев амиодарона для урежения частоты желудочковых сокращений. Описаны особенности и дискуссионные вопросы проведения тройной антитромботической терапии у больных с ФП при ИМпST, возможности и показания для применения вместо нее двойной антитромботической терапии. Определена клиническая значимость и особенности лечения различных видов ЖА, подчеркнута роль реваскуляризации миокарда, радиочастотной катетерной аблации, нормализации электролитного дисбаланса, применения бета-адреноблокаторов и амиодарона в терапии жизнеопасных желудочковых нарушений ритма сердца. Отмечена нерациональность, а иногда и опасность проведения профилактической антиаритмической терапии ФП и ЖА в острой стадии ИМпST, а также роль имплантации кардиовертера-дефибриллятора в первичной профилактике смерти у определенных групп больных с низкой фракцией выброса левого желудочка, перенесших ИМ. Дана оценка значению различных антиаритмических препаратов в их влиянии на улучшение прогноза у больных после ИМпST. За основу изложения материала взяты современные рекомендации по лечению больных с ИМпST, терапии ФП и ЖА, профилактике внезапной сердечной смерти, а также данные ряда контролируемых исследований и собственный клинический опыт фармакотерапии аритмий.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фибрилляция предсердий</kwd><kwd>желудочковые аритмии</kwd><kwd>инфаркт миокарда с подъемом сегмента ST</kwd><kwd>бета-адреноблокаторы</kwd><kwd>амиодарон</kwd><kwd>фармакологическая кардиоверсия</kwd><kwd>электроимпульсная терапия</kwd><kwd>имплантируемый кардиовертер-дефибриллятор</kwd></kwd-group><kwd-group xml:lang="en"><kwd>atrial fibrillation</kwd><kwd>ventricular arrhythmias</kwd><kwd>ST-segment elevation myocardial infarction</kwd><kwd>beta-blockers</kwd><kwd>amiodarone</kwd><kwd>pharmacological cardioversion</kwd><kwd>electrical cardioversion</kwd><kwd>implantable cardioverter-defibrillator</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">2017 ESC guidelines for the management of acute myocardial infarction in patients presenting withST-segment elevation. Eur Heart J. 2018;39:119-77. doi: 10.1093/eurheartj/ehx393.</mixed-citation><mixed-citation xml:lang="en">2017 ESC guidelines for the management of acute myocardial infarction in patients presenting withST-segment elevation. Eur Heart J. 2018;39:119-77. doi: 10.1093/eurheartj/ehx393.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Schmitt J., Duray G., Gersh B.J., Hohnloser S.H. Atrial fibrillation in acute myocardial infarction. Eur Heart J. 2009;30:1038-45. doi: 10.1093/eurheartj/ehn579.</mixed-citation><mixed-citation xml:lang="en">Schmitt J., Duray G., Gersh B.J., Hohnloser S.H. Atrial fibrillation in acute myocardial infarction. Eur Heart J. 2009;30:1038-45. doi: 10.1093/eurheartj/ehn579.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Jabre P., Jouven X., Adnet F. et al. Atrial fibrillation and death аfter myocardial infarction: a community study. Circulation. 2011;123:2094-100. doi: 10.1161/CIRCULATIONAHA.110.990192.</mixed-citation><mixed-citation xml:lang="en">Jabre P., Jouven X., Adnet F. et al. Atrial fibrillation and death аfter myocardial infarction: a community study. Circulation. 2011;123:2094-100. doi: 10.1161/CIRCULATIONAHA.110.990192.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Jabre P., Roder V.L., Murad M.H. et al. Mortality associated with atrial fibrillation in patients with myocardial infarction. Circulation. 2011;123:1587-93. doi.org/10.1161/CIRCULATIONAHA. 110.986661.</mixed-citation><mixed-citation xml:lang="en">Jabre P., Roder V.L., Murad M.H. et al. Mortality associated with atrial fibrillation in patients with myocardial infarction. Circulation. 2011;123:1587-93. doi.org/10.1161/CIRCULATIONAHA. 110.986661.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Crenshow B.S., Ward S.R., Granger C.B. et al. Atrial fibrillation in the setting of acute myocardial infarction. J Am Coll Cardiol. 1997;30:406-13.</mixed-citation><mixed-citation xml:lang="en">Crenshow B.S., Ward S.R., Granger C.B. et al. Atrial fibrillation in the setting of acute myocardial infarction. J Am Coll Cardiol. 1997;30:406-13.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Cardiac arrhythmias in acute coronary syndromes: position paper from the joint EHRA, ACCA and EAPCI task force. Europace. 2014;16:1655-673. doi: 10.1093/europace/euu208.</mixed-citation><mixed-citation xml:lang="en">Cardiac arrhythmias in acute coronary syndromes: position paper from the joint EHRA, ACCA and EAPCI task force. Europace. 2014;16:1655-673. doi: 10.1093/europace/euu208.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation. J. Am. Coll. Cardiol. 2014;64(21):e1-e76. doi: 10.1016/j.jacc.2014.03.022.</mixed-citation><mixed-citation xml:lang="en">2014 AHA/ACC/HRS guideline for the management of patients with atrial fibrillation. J. Am. Coll. Cardiol. 2014;64(21):e1-e76. doi: 10.1016/j.jacc.2014.03.022.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS. Eur Heart J. 2018;39(3):213-60. doi.org/10.1093/eurheartj/ehx419.</mixed-citation><mixed-citation xml:lang="en">2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS. Eur Heart J. 2018;39(3):213-60. doi.org/10.1093/eurheartj/ehx419.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Risius T., Mortensen K., Schwermer T.F. et al.Comparison of anterio-lateral versus anterio-posterior electrode position for biphasic external cardioversion of atrial flutter. Am J Cardiol. 2009;104:154750. doi: 10.1016/j.amjcard.2009.07.027.</mixed-citation><mixed-citation xml:lang="en">Risius T., Mortensen K., Schwermer T.F. et al.Comparison of anterio-lateral versus anterio-posterior electrode position for biphasic external cardioversion of atrial flutter. Am J Cardiol. 2009;104:154750. doi: 10.1016/j.amjcard.2009.07.027.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Manegold J.C., Israel C.W., Ehrlich J.R. et al. External cardioversion of atrial fibrillation in patients with implanted pacemaker or cardioverter-defibrillator. Eur Heart J. 2007;28:1731-8. doi: 10.1093/eurheartj/ehm211.</mixed-citation><mixed-citation xml:lang="en">Manegold J.C., Israel C.W., Ehrlich J.R. et al. External cardioversion of atrial fibrillation in patients with implanted pacemaker or cardioverter-defibrillator. Eur Heart J. 2007;28:1731-8. doi: 10.1093/eurheartj/ehm211.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Priori S.G., Blomstrom-Lundgvist C., Mazzanti A. et al. 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur. Heart J. 2015;36:2793-867. doi: 10.1093/europace/euv319.</mixed-citation><mixed-citation xml:lang="en">Priori S.G., Blomstrom-Lundgvist C., Mazzanti A. et al. 2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur. Heart J. 2015;36:2793-867. doi: 10.1093/europace/euv319.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Piccini J.P., Schulte P.J., Pieper K.S. et al. Antiarrhythmic drug therapy for sustained ventricular arrhythmias complicating acute myocardial infarction. Crit Care Med. 2011;39:78-83. doi: 10.1097/CCM.0b013e3181fd6ad7.</mixed-citation><mixed-citation xml:lang="en">Piccini J.P., Schulte P.J., Pieper K.S. et al. Antiarrhythmic drug therapy for sustained ventricular arrhythmias complicating acute myocardial infarction. Crit Care Med. 2011;39:78-83. doi: 10.1097/CCM.0b013e3181fd6ad7.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">He X.Z., Zhou S.H., Wan X.H. et al. The effect early and intensive statin therapy on ventricular premature beat or nonsustained ventricular tachycardia in patients with acute coronary syndrome. Clin Cardiol. 2011;34:59-63. doi: 10.1002/clc.20818.</mixed-citation><mixed-citation xml:lang="en">He X.Z., Zhou S.H., Wan X.H. et al. The effect early and intensive statin therapy on ventricular premature beat or nonsustained ventricular tachycardia in patients with acute coronary syndrome. Clin Cardiol. 2011;34:59-63. doi: 10.1002/clc.20818.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. 2015;36(41):2793-867. doi: 10.1093/eurheartj/ ehv316.</mixed-citation><mixed-citation xml:lang="en">2015 ESC guidelines for the management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. Eur Heart J. 2015;36(41):2793-867. doi: 10.1093/eurheartj/ ehv316.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction. Circulation. 2013;127:e362-e425. doi: 10.1161/CIR.0b013e3182742cf6.</mixed-citation><mixed-citation xml:lang="en">2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction. Circulation. 2013;127:e362-e425. doi: 10.1161/CIR.0b013e3182742cf6.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Cardiac Arrhythmia Suppression Trial (CAST) investigators. Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N Engl J Med. 1989;321(6):406-12. doi: 10.1056/NEJM198908103210629.</mixed-citation><mixed-citation xml:lang="en">Cardiac Arrhythmia Suppression Trial (CAST) investigators. Preliminary report: effect of encainide and flecainide on mortality in a randomized trial of arrhythmia suppression after myocardial infarction. N Engl J Med. 1989;321(6):406-12. doi: 10.1056/NEJM198908103210629.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">The cardiac arrhythmia suppression trial II investigators. Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction. N Engl J Med. 1992;327(4):227-33. doi: 10.1056/NEJM199207233270403.</mixed-citation><mixed-citation xml:lang="en">The cardiac arrhythmia suppression trial II investigators. Effect of the antiarrhythmic agent moricizine on survival after myocardial infarction. N Engl J Med. 1992;327(4):227-33. doi: 10.1056/NEJM199207233270403.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Teo K.K., Yusuf S., Furberg C.D. Effects prophylactic antiarrhythmic drug therapy in acute myocardial infarction. JAMA. 1993;270(13):1589-95.</mixed-citation><mixed-citation xml:lang="en">Teo K.K., Yusuf S., Furberg C.D. Effects prophylactic antiarrhythmic drug therapy in acute myocardial infarction. JAMA. 1993;270(13):1589-95.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Antman E.M. ST-elevation myocardial infarction: management. In Braunwald E., Zipes L., Libby P., Bonow R. (eds). Heart disease. Philadelphia: W.B. Saunders company; 2005. P.1167-1226.</mixed-citation><mixed-citation xml:lang="en">Antman E.M. ST-elevation myocardial infarction: management. In Braunwald E., Zipes L., Libby P., Bonow R. (eds). Heart disease. Philadelphia: W.B. Saunders company; 2005. P.1167-1226.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Бунин Ю.А. Возможности антиаритмической терапии в первичной профилактике смерти у больных с желудочковыми аритмиями. Рациональная Фармакотерапия в Кардиологии. 2010;6(6):870-5. doi: 10.20996/1819-6446-2010-6-6-870-875.</mixed-citation><mixed-citation xml:lang="en">Bunin Y.A. The possibilities of antiarrhythmic therapy in primary prevention of death in patients with ventricular arrhythmias. Rational Pharmacotherapy in Cardiology. 2010;6(6):870-5. (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Bardy G.H., Lee K.L., Mark D.B. et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005;352:225-37. doi: 10.1056/NEJMoa043399.</mixed-citation><mixed-citation xml:lang="en">Bardy G.H., Lee K.L., Mark D.B. et al. Amiodarone or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med. 2005;352:225-37. doi: 10.1056/NEJMoa043399.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Boutitie F., Boissel J.P., Connoly S.J. et al. Amiodarone interaction with beta-blokers: analysis of the merged EMIAT and CAMIAT detabases. Circulation. 1999;99:2268-75. doi: 10.1161/01.CIR. 99.17.2268.</mixed-citation><mixed-citation xml:lang="en">Boutitie F., Boissel J.P., Connoly S.J. et al. Amiodarone interaction with beta-blokers: analysis of the merged EMIAT and CAMIAT detabases. Circulation. 1999;99:2268-75. doi: 10.1161/01.CIR. 99.17.2268.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. ACC (2017). J Am Coll Cardiol. 2017 Oct 25. pii: S07351097(17)41306-4. doi: 10.1016/j.jacc.2017.10.054.</mixed-citation><mixed-citation xml:lang="en">2017 AHA/ACC/HRS guideline for management of patients with ventricular arrhythmias and the prevention of sudden cardiac death. ACC (2017). J Am Coll Cardiol. 2017 Oct 25. pii: S07351097(17)41306-4. doi: 10.1016/j.jacc.2017.10.054.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
