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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2018-14-5-691-698</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-1757</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NOTES FROM PRACTICE</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ ОПЫТ</subject></subj-group></article-categories><title-group><article-title>Clinical Case: Tuberculous Myopericarditis in the Cardiology Practice</article-title><trans-title-group xml:lang="ru"><trans-title>Клиническое наблюдение: туберкулезный миоперикардит в практике врача кардиолога</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Скрипка</surname><given-names>А. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Skripka</surname><given-names>A. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119435, Москва, ул. Большая Пироговская, д.2, стр. 4.</p></bio><bio xml:lang="en"><p>Alena I. Skripka – MD, Post-Graduate Student, Chair of Faculty Therapy N1, Medical Faculty.</p><p>Bolshaya Pirogovskaya ul. 2-4, Moscow, 119435.</p><p> </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бучнева</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Buchneva</surname><given-names>A. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>119435, Москва, ул. Большая Пироговская, д.2, стр. 4.</p></bio><bio xml:lang="en"><p>Anna V. Buchneva – 6-th Year Student.</p><p>Bolshaya Pirogovskaya ul. 2-4, Moscow, 119435.</p><p> </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ванхин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Vankhin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Ванхин Вера Владимировна – студентка 5 курса, лечебный факультет.</p><p>119435, Москва, ул. Большая Пироговская, д.2, стр. 4.</p><p> </p></bio><bio xml:lang="en"><p>Vera V. Vankhin  – 5-th Year Student.</p><p>Bolshaya Pirogovskaya ul. 2-4, Moscow, 119435.</p><p> </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лисянская</surname><given-names>Н. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lisyanskaya</surname><given-names>N. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Лисянская Наталия Владимировна – студентка 5 курса, Международная школа «Медицина будущего», Научно-технологический парк биомедицины.</p><p>119435, Москва, ул. Большая Пироговская, д.2, стр. 4.</p><p> </p></bio><bio xml:lang="en"><p>Natalia V. Lisyanskaya – 5-th Year Student, Sechenov University International School, Science and Technology Park for Biomedicine.</p><p>Bolshaya Pirogovskaya ul. 2-4, Moscow, 119435.</p><p> </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Бабырэ</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Babyre</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Бабырэ Виктория Васильевна – кандидат медицинских наук,  ассистент, кафедра факультетской терапии №1, лечебный факультет.</p><p>119435, Москва, ул. Большая Пироговская, д.2, стр. 4.</p><p> </p></bio><bio xml:lang="en"><p>Victoria V. Babyre – MD, PhD, Assistant, Chair of Faculty Therapy N1, Medical Faculty.</p><p>Bolshaya Pirogovskaya ul. 2-4, Moscow, 119435.</p><p> </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сенчихин</surname><given-names>П. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Senchikhin</surname><given-names>P. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сенчихин Павел Владимирович – кандидат медицинских наук, доцент, кафедра фтизиопульмонологии и торакальной хирургии.</p><p>119435, Москва, ул. Большая Пироговская, д.2, стр. 4.</p><p> </p></bio><bio xml:lang="en"><p>Pavel V. Senchikhin – MD, PhD, Associate Professor, Chair of Phthisiopulmonology and Thoracic Surgery.</p><p>Bolshaya Pirogovskaya ul. 2-4, Moscow, 119435.</p><p> </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Соколова</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Sokolova</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Соколова Анастасия Андреевна – кандидат медицинских наук,  ассистент, кафедра  факультетской терапии №1, лечебный факультет.</p><p>119435, Москва, ул. Большая Пироговская, д.2, стр. 4.</p><p> </p></bio><bio xml:lang="en"><p>Anastasiya A. Sokolova – MD, PhD, Assistant, Chair of Faculty Therapy N1, Medical Faculty.</p><p>Bolshaya Pirogovskaya ul. 2-4, Moscow, 119435.</p><p> </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Напалков</surname><given-names>Д. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Napalkov</surname><given-names>D. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Напалков Дмитрий Александрович – доктор медицинских наук, профессор, кафедра  факультетской терапии №1, лечебный факультет.</p><p>119435, Москва, ул. Большая Пироговская, д.2, стр. 4.</p><p> </p></bio><bio xml:lang="en"><p>Dmitry A. Napalkov – MD, PhD, Professor, Chair of Faculty Therapy N1, Medical Faculty.</p><p>Bolshaya Pirogovskaya ul. 2-4, Moscow, 119435.</p><p> </p></bio><email xlink:type="simple">dminap@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фомин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fomin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фомин Виктор Викторович – доктор медицинских наук, профессор, член-корреспондент РАН, заведующий кафедрой факультетской терапии №1, лечебный факультет.</p><p>119435, Москва, ул. Большая Пироговская, д.2, стр. 4.</p><p> </p></bio><bio xml:lang="en"><p>Viktor V. Fomin – MD, PhD, Professor, Corresponding Member of the Russian Academy of Sciences, Head of Chair of Faculty Therapy N1, Medical Faculty.</p><p>Bolshaya Pirogovskaya ul. 2-4, Moscow, 119435.</p><p> </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И.М. Сеченова (Сеченовский университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow  State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>02</day><month>11</month><year>2018</year></pub-date><volume>14</volume><issue>5</issue><fpage>691</fpage><lpage>698</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Skripka A.I., Buchneva A.V., Vankhin V.V., Lisyanskaya N.V., Babyre V.V., Senchikhin P.V., Sokolova A.A., Napalkov D.A., Fomin V.V., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Скрипка А.И., Бучнева А.В., Ванхин В.В., Лисянская Н.В., Бабырэ В.В., Сенчихин П.В., Соколова А.А., Напалков Д.А., Фомин В.В.</copyright-holder><copyright-holder xml:lang="en">Skripka A.I., Buchneva A.V., Vankhin V.V., Lisyanskaya N.V., Babyre V.V., Senchikhin P.V., Sokolova A.A., Napalkov D.A., Fomin V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/1757">https://www.rpcardio.online/jour/article/view/1757</self-uri><abstract><p>Pericarditis is not enough researched and described in literature despite the emergence of a large quantity of up-to-date laboratory and instrumental methods of verification. The main problem is that  pericarditis might be a sign of many infectious and non-infectious diseases. It is quite difficult to define the etiopathogenetic reason of process. The article presents a clinical observation of a 53 years old mail patient with paroxysms of atrial flutter, non-symptomatic febrile fever, arthralgia and  signs of exudative pericarditis, which were  manifested after  the acute  viral infection. The symptoms have been lasting for 8 months before the patient’s hospitalization. In lab tests anemia, leucopenia, increase level of platelets and increase antinuclear antibody level were found. Several conceptions were considered: cancer with paraneoplastic syndrome, systemic disease, infectious process, myeloma, which were subsequently excluded. Due to the fact that pericardial effusion may often be associated with tuberculosis Diaskin test and T-SPOT were performed and they appeared to be positive. After several months of antituberculous treatment temperature normalized, atrial flutter episodes and arthralgia diminished. So empirically and  laboratory tuberculous pericarditis with atypical manifestation was  confirmed. The particularity of this observation is a nontypical clinical picture and the absence of a primary focus of infection. That is why the clinicians could not define the diagnosis rapidly.</p></abstract><trans-abstract xml:lang="ru"><p>Перикардит является  проявлением многих  инфекционных и неинфекционных заболеваний, это – основная сложность, с которой  может столкнуться клиницист, поэтому  нередко установить  этиопатогенетическую природу процесса в кратчайшие сроки  не представляется возможным. В статье приводится клиническое наблюдение пациента 53-х  лет с пароксизмами фибрилляции предсердий, асимптомной фебрильной лихорадкой, артралгиями и признаками экссудативного перикардита. Данные  симптомы  манифестировали после перенесенной вирусной инфекции, а длительность заболевания до обращения к докторам факультетской терапевтической клиники Университетской клинической  больницы №1 г. Москвы составила 8 мес. По результатам лабораторных тестов у пациента наблюдались признаки анемии, лейкопении,  тромбоцитоза и повышения уровня  антинуклеарных антител. Были рассмотрены следующие концепции этиопатогенеза: онкологический  процесс   с  паранеопластическим синдромом,  системное заболевание  соединительное ткани,  инфекционное заболевание, множественная миелома, которые в дальнейшем были исключены.  Хронизация процесса в виде постепенной нормализации температуры и острофазовых показателей, изменения характера перикардита на констриктивный позволила клиницистам предположить туберкулезный характер перикардита, после получения положительных результатов T-SPOT и диаскин-теста пациенту было назначено противотуберкулезное лечение. После нескольких месяцев проведения противотуберкулезной терапии наблюдалась положительная динамика в состоянии пациента – нормализовалась температура, эпизоды артралгии не беспокоили, пароксизмы фибрилляции предсердий стали редкими. Таким образом, эмпирически и лабораторно был поставлен диагноз туберкулезного миоперикардита с атипичной манифестацией. Особенностью данного клинического случая является нетипичная клиническая картина и отсутствие первичного очага инфекции, что не позволило клиницистам поставить диагноз в короткие  сроки.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>туберкулезный перикардит</kwd><kwd>туберкулезный миокардит</kwd><kwd>фибрилляция предсердий</kwd><kwd>лихорадка неясного  генеза</kwd></kwd-group><kwd-group xml:lang="en"><kwd>tuberculous pericarditis</kwd><kwd>tuberculous myocarditis</kwd><kwd>atrial flutter</kwd><kwd>fever of unknown origin</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Sagristà-Sauleda J., Permanyer-Miralda G., Soler-Soler J. Tuberculous pericarditis: ten-year experience with a prospective protocol for diagnosis and treatment. 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