rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2019-15-1-69-76rpcardio-1861Research ArticleASSOCIATED PROBLEMS OF CARDIOLOGYСМЕЖНЫЕ ВОПРОСЫ КАРДИОЛОГИИAtherosclerosis and Osteoporosis. Common Targets for the Effects of Cardiovascular and Anti-osteoporotic Drugs (Part I). The Effect of Cardiovascular Drugs on Bone StrengthАтеросклероз и остеопороз. Общие мишени для влияния сердечно-сосудистых и антиостеопорозных препаратов (Часть I). Влияние сердечно-сосудистых препаратов на прочность костной тканиСкрипниковаИ. А.SkripnikovaI. A.

д.м.н., руководитель отдела профилактики остеопороза,

101990, Москва, Петроверигский пер., 10

MD, PhD., Head of Osteoporosis Prevention Department,

Petroverigsky per. 10, Moscow, 101990

ISkripnikova@gnicpm.ruАлихановаН. А.AlikhanovaN. A.

м.н.с., отдел профилактики остеопороза,

101990, Москва, Петроверигский пер., 10

PhD, Junior Researcher, Osteoporosis Prevention Department,

Petroverigsky per. 10, Moscow, 101990

КолчинаМ. А.KolchinаM. A.

врач, консультативное отделение,

101990, Москва, Петроверигский пер., 10

MD, Doctor, Advisory Department,

Petroverigsky per. 10, Moscow, 101990

МягковаМ. А.MyagkovaM. A.

н.с., отдел профилактики остеопороза,

101990, Москва, Петроверигский пер., 10

Researcher, Osteoporosis Prevention Department, 

Petroverigsky per. 10, Moscow, 101990

КосматоваО. В.KosmatovaO. V.

к.м.н., с.н.с., отдел профилактики остеопороза,

101990, Москва, Петроверигский пер., 10

MD, PhD, Senior Researcher, Osteoporosis Prevention Department, 

Petroverigsky per. 10, Moscow, 101990

Национальный медицинский исследовательский центр профилактической медициныРоссияNational Medical Research Center for Preventive MedicineRussian Federation2019030320191516976Copyright © Skripnikova I.A., Alikhanova N.A., Kolchinа M.A., Myagkova M.A., Kosmatova O.V., 20192019Скрипникова И.А., Алиханова Н.А., Колчина М.А., Мягкова М.А., Косматова О.В.Skripnikova I.A., Alikhanova N.A., Kolchinа M.A., Myagkova M.A., Kosmatova O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1861

Daily use of antihypertensive and lipid-lowering drugs in clinical practice dictates the need for knowledge of their pleiotropic effects. The article presents the results of studies of the effect of cardiovascular drugs, such as statins, beta-blockers, ACE inhibitors, diuretics, calcium antagonists and nitrates on bone mineral density and fractures associated with osteoporosis. The mechanisms of action of drugs on bone mass, markers of bone metabolism, the frequency of fractures in osteoporosis are discussed. Most studies show that the use of cardiac drugs along with a positive effect on the vascular wall, slow bone resorption and increase bone mass. Knowledge of the additional effect on bone metabolism of drugs used in cardiovascular diseases allows to choose an adequate therapy and improve the prognosis of both diseases.

Повседневное применение в клинической практике гипотензивных и липидснижающих препаратов диктует необходимость знаний их разнообразных плейотропных эффектов. В статье представлены результаты работ по влиянию сердечно-сосудистых препаратов, таких как статины, бета-адреноблокаторы, ингибиторы ангиотензин-превращающего фермента, диуретики, антагонисты кальция и нитраты на минеральную плотность кости и развитие переломов, связанных с остеопорозом. Раскрыты механизмы действия препаратов на костную массу, маркеры костного метаболизма, на частоту переломов при остеопорозе. Большинство работ свидетельствуют о том, что использование кардиологических препаратов наряду с положительным влиянием на сосудистую стенку замедляют костную резорбцию и повышают костную массу. Знания о дополнительном влиянии на костный обмен сердечно-сосудистых препаратов позволят выбрать адекватную терапию и улучшить прогноз обоих заболеваний.

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The authors declare that there are no conflicts of interest present.