rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2019-15-1-95-104rpcardio-1865Research ArticlePOINT OF VIEWТОЧКА ЗРЕНИЯPharmacological Basis of the Clinical Efficacy of Varenicline Used to Facilitate Smoking CessationФармакологические основы клинической эффективности варениклина, применяемого с целью облегчения прекращения куренияГиляревскийС. Р.GilyarevskiyS. R.

д.м.н., профессор, кафедра клинической фармакологии и терапии,

125993, Москва, ул. Баррикадная, 2/1

MD, PhD, Professor, Chair of Clinical Pharmacology and Therapy,

Barrikadnaya ul. 2/1, Moscow, 125993

sgilarevsky@rambler.ruРоссийская медицинская академия непрерывного профессионального образованияРоссияRussian Medical Academy of Continuing Professional EducationRussian Federation20190303201915195104Copyright © Gilyarevskiy S.R., 20192019Гиляревский С.Р.Gilyarevskiy S.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1865

Modern problems caused by the high prevalence of smoking, as well as pharmacological approaches that facilitate quitting smoking are discussed in the review. Data on the mechanisms of formation of nicotine addiction, which determine the choice of drug interventions aimed at increasing the probability of quitting smoking are presented. The pharmacological characteristics of the most commonly used drugs used to facilitate smoking cessation are given. Special attention is paid to data on the mechanisms of action of varenicline and evidence of its clinical efficacy and safety, including in patients with concomitant cardiovascular diseases, as well as in patients with a history of acute coronary syndrome. Evidence on the effectiveness of the combined use of varenicline and nicotine replacement therapy are presented.

В обзоре литературы рассматриваются современные проблемы, обусловленные высокой распространенностью курения, а также фармакологические подходы, облегчающие отказ от курения. Приводятся данные о механизмах формирования никотиновой зависимости, которые определяют выбор медикаментозных вмешательств, направленных на увеличение вероятности отказа от курения. Приводятся фармакологические характеристики наиболее часто применяемых препаратов для облегчения отказа от курения. Особое внимание уделяется данным о механизмах действия варениклина и доказательствам его клинической эффективности и безопасности, в том числе, у больных с сопутствующими сердечно-сосудистыми заболеваниями в целом, и у больных, перенесших острый коронарный синдром. Приводятся доказательные данные об эффективности сочетанного применения варениклина и никотинзамещающей терапии.

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The authors declare that there are no conflicts of interest present.