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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2019-15-1-105-114</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-1866</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group></article-categories><title-group><article-title>New Guidelines on Management of Arterial Hypertension: Key Similarities and Differences</article-title><trans-title-group xml:lang="ru"><trans-title>Современные рекомендации по артериальной гипертонии: согласованные и несогласованные позиции</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кобалава</surname><given-names>Ж. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Kobalava</surname><given-names>Zh. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, зав. кафедрой внутренних болезней с курсом кардиологии и функциональной диагностики им. академика В.С. Моисеева, </p><p>117198, Москва, ул. Миклухо-Маклая, 6</p></bio><bio xml:lang="en"><p>MD, PhD, Professor, Head of Chair of Internal Medicine with the Subspecialty of Cardiology and Functional Diagnostics named after V.S. Moiseev,</p><p>Miklukho-Maklaya ul. 6, Moscow, 117198 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Троицкая</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Troitskaya</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., доцент, кафедра внутренних болезней с курсом кардиологии и функциональной диагностики им. академика В.С. Моисеева,  </p><p>117198, Москва, ул. Миклухо-Маклая, 6</p></bio><bio xml:lang="en"><p>MD, PhD, Associate Professor, Chair of Internal Medicine with the Subspecialty of Cardiology and Functional Diagnostics named after V.S. Moiseev,</p><p>Miklukho-Maklaya ul. 6, Moscow, 117198 </p></bio><email xlink:type="simple">trelen@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Колесник</surname><given-names>Э. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Kolesnik</surname><given-names>E. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., ассистент, кафедра внутренних болезней с курсом кардиологии и функциональной диагностики им. академика В.С. Моисеева,  </p><p>117198, Москва, ул. Миклухо-Маклая, 6</p></bio><bio xml:lang="en"><p>MD, PhD, Assistant, Chair of Internal Medicine with the Subspecialty of Cardiology and Functional Diagnostics named after V.S. Moiseev,</p><p>Miklukho-Maklaya ul. 6, Moscow, 117198 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский университет дружбы народов, Медицинский институт</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Peoples’ Friendship University of Russia (RUDN University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>03</day><month>03</month><year>2019</year></pub-date><volume>15</volume><issue>1</issue><fpage>105</fpage><lpage>114</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kobalava Z.D., Troitskaya E.A., Kolesnik E.L., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Кобалава Ж.К., Троицкая Е.А., Колесник Э.Л.</copyright-holder><copyright-holder xml:lang="en">Kobalava Z.D., Troitskaya E.A., Kolesnik E.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/1866">https://www.rpcardio.online/jour/article/view/1866</self-uri><abstract><p>Steady increase in worldwide prevalence of hypertension and hypertension-related cardiovascular morbidity and mortality necessitate new approaches to the management of hypertensive patients. It`s important to recognize that despite several differences the convergence of the 2017 ACC/AHA (US) and 2018 ESC/ESH (European) guidelines is greater now than ever before. The present review focuses on the key similarities and differences of these two documents. Among similarities we analyzed positions regarding the importance of cardiovascular risk evaluation for treatment initiation and choice of optimal treatment strategy: blood pressure (BP) treatment thresholds; drugs of choice for the initiation of antihypertensive therapy and treatment targets in different groups including elderly patients. Among key differences we analyzed sections concerning the classification of BP levels and target BP levels in patients with chronic kidney disease. In conclusion, we may say that in many ways the guidelines are just a different interpretation of the same data. There is no doubt in the importance of lowering high BP and evaluation and correction of high cardiovascular risk. One of the main purposes is to focus attention on younger patients with hypertension.</p></abstract><trans-abstract xml:lang="ru"><p>Неуклонный рост распространенности артериальной гипертонии (АГ) и ассоциированных с ней сердечно-сосудистых заболеваний диктует необходимость новых подходов к диагностике и лечению АГ. Опубликованные в 2017 г. рекомендации Американской коллегии кардиологов (ACC/AHA) и опубликованные в 2018 г. рекомендации Европейского кардиологического общества (ESC/ESH), несмотря на некоторые отличия, как никогда раньше сходятся по ключевым вопросам лечения пациентов с АГ. Цель обзора – обсудить позиции сходства и отличия двух документов. В обзоре представлен подробный анализ разделов рекомендаций, касающихся важности оценки сердечно-сосудистого риска для начала и выбора терапии, пороговых уровней артериального давления (АД) для инициации медикаментозного лечения, препаратов выбора для стартовой терапии АГ, целевых значений АД на фоне лечения (в том числе у пожилых). Среди позиций различия подробно проанализированы разделы, касающиеся классификации АД и диагностики АГ, взглядов на лечение АГ при хронической болезни почек. Обсуждаются возможные причины введения нижней границы безопасности снижения АД в европейских рекомендациях. В заключение подчеркивается, что рекомендации ESC/ESH (2018 г.) и ACC/AHA (2017 г.) по многим позициям представляют собой разную трактовку результатов одних и тех же исследований и мета-анализов. Нет сомнений в необходимости снижения повышенного АД и параллельной глобальной оценке и коррекции сердечно-сосудистого риска, причем одной из главных целей рекомендаций 2017 и 2018 гг. является привлечение внимания к данной проблеме у молодых лиц.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальное давление</kwd><kwd>артериальная гипертония</kwd><kwd>антигипертензивная терапия</kwd><kwd>рекомендации по лечению артериальной гипертонии</kwd><kwd>сердечно-сосудистый риск</kwd></kwd-group><kwd-group xml:lang="en"><kwd>blood pressure</kwd><kwd>arterial hypertension</kwd><kwd>antihypertensive therapy</kwd><kwd>hypertension guidelines</kwd><kwd>cardiovascular risk</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lim S.S., Vos T., Flaxman A.D. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2224-60. doi:10.1016/S0140-6736(12)61766-8.</mixed-citation><mixed-citation xml:lang="en">Lim S.S., Vos T., Flaxman A.D. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990-2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012;380(9859):2224-60. doi:10.1016/S0140-6736(12)61766-8.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants. Lancet. 2017;389(10064):37-55. doi:10.1016/S0140-6736(16)31919-5.</mixed-citation><mixed-citation xml:lang="en">NCD Risk Factor Collaboration (NCD-RisC). Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19.1 million participants. Lancet. 2017;389(10064):37-55. doi:10.1016/S0140-6736(16)31919-5.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Roth G.A., Johnson C., Abajobir A. et al. Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015. J Am Coll Cardiol. 2017;70(1):1-25. doi:10.1016/j.jacc.2017.04.052</mixed-citation><mixed-citation xml:lang="en">Roth G.A., Johnson C., Abajobir A. et al. Global, regional, and national burden of cardiovascular diseases for 10 causes, 1990 to 2015. J Am Coll Cardiol. 2017;70(1):1-25. doi:10.1016/j.jacc.2017.04.052</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">GBD 2013 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1659-724. doi:10.1016/S0140-6736(16)31679-8.</mixed-citation><mixed-citation xml:lang="en">GBD 2013 Risk Factors Collaborators. Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet. 2016;388(10053):1659-724. doi:10.1016/S0140-6736(16)31679-8.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Gaziano T.A., Bitton A., Anand S., Weinstein M.C. The global cost of nonoptimal blood pressure. J Hypertens. 2009;27(7):1472-7. doi:10.1097/HJH.0b013e32832a9ba3.</mixed-citation><mixed-citation xml:lang="en">Gaziano T.A., Bitton A., Anand S., Weinstein M.C. The global cost of nonoptimal blood pressure. J Hypertens. 2009;27(7):1472-7. doi:10.1097/HJH.0b013e32832a9ba3.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Бойцов С. А., Баланова Ю. А., Шальнова С. А. и др. Артериальная гипертония среди лиц 25-64 лет: распространенность, осведомленность, лечение и контроль. По материалам исследования ЭССЕ. Кардиоваскулярная Терапия и Профилактика. 2014;13(4):4-14. doi:10.15829/1728-8800-2014-4-4-14.</mixed-citation><mixed-citation xml:lang="en">Boytsov S.A., Balanova Y.A., Shalnova S.A. et al. Arterial hypertension among individuals of 25-64 years old: prevalence, awareness, treatment and control. By the data from ECCD. Cardiovascular Therapy and Prevention 2014;13(4):4-14 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Оганов Р.Г., Тимофеева Т. Н., Колтунов И. Е. и др. Эпидемиология артериальнойгипертонии в России. Результаты федерального мониторинга 2003-2010 гг. Кардиоваскулярная Терапия и Профилактика. 2011;10(1):9-13.</mixed-citation><mixed-citation xml:lang="en">Oganov R.G., Timofeeva T.N., Koltunov I.E. et al. Arterial hypertension epidemiology in Russia; the results of 2003-2010 federal monitoring. Cardiovascular Therapy and Prevention 2011;10(1):9-13 (In Russ.)</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Noncommunicable Diseases Global Monitoring Framework: Indicator Definitions and Specifications [cited by Feb 12, 2019]. Available from: https://www.who.int/nmh/ncd-tools/indicators/GMF_Indicator_Definitions_FinalNOV2014.pdf?ua=1.</mixed-citation><mixed-citation xml:lang="en">Noncommunicable Diseases Global Monitoring Framework: Indicator Definitions and Specifications [cited by Feb 12, 2019]. Available from: https://www.who.int/nmh/ncd-tools/indicators/GMF_Indicator_Definitions_FinalNOV2014.pdf?ua=1.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Whelton P.K., Carey R.M., Aronow W.S. et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71(6):1269-324. doi:10.1161/HYP.0000000000000066.</mixed-citation><mixed-citation xml:lang="en">Whelton P.K., Carey R.M., Aronow W.S. et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71(6):1269-324. doi:10.1161/HYP.0000000000000066.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Williams B., Mancia G., Spiering W. et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens. 2018;36(10):1953-2041. doi:10.1097/HJH.0000000000001940.</mixed-citation><mixed-citation xml:lang="en">Williams B., Mancia G., Spiering W. et al. 2018 ESC/ESH Guidelines for the management of arterial hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension: The Task Force for the management of arterial hypertension of the European Society of Cardiology and the European Society of Hypertension. J Hypertens. 2018;36(10):1953-2041. doi:10.1097/HJH.0000000000001940.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Кобалава Ж.Д., Конради А.О., Недогода С.В. и др. Меморандум экспертов Российского кардиологического общества по рекомендациям Европейского общества кардиологов/Европейского общества по артериальной гипертензии по лечению артериальной гипертензии 2018 г. Российский Кардиологический Журнал. 2018;(12):131-42. doi:10.15829/1560-4071-2018-12-131-142.</mixed-citation><mixed-citation xml:lang="en">Kobalava Z.D., Konradi A.O., Nedogoda S.V. et al. Russian Society of Cardiology position paper on 2018 Guidelines of the European Society of Cardiology/European Society of Arterial Hypertension for the management of arterial hypertension. Russian Journal of Cardiology. 2018;(12):131-42 (In Russ.). doi:10.15829/1560-4071-2018-12-131-142.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Whelton P.K., Williams B. The 2018 European Society of Cardiology/European Society of Hypertension and 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines: more similar than different. JAMA. 2018;320(17):1749-50. doi:10.1001/jama.2018. 16755.</mixed-citation><mixed-citation xml:lang="en">Whelton P.K., Williams B. The 2018 European Society of Cardiology/European Society of Hypertension and 2017 American College of Cardiology/American Heart Association Blood Pressure Guidelines: more similar than different. JAMA. 2018;320(17):1749-50. doi:10.1001/jama.2018. 16755.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Bakris G., Sorrentino M. Perspective on the new blood-pressure guidelines. Eur Heart J. 2018;39(33):3008-9. doi:10.1093/eurheartj/ehy280</mixed-citation><mixed-citation xml:lang="en">Bakris G., Sorrentino M. Perspective on the new blood-pressure guidelines. Eur Heart J. 2018;39(33):3008-9. doi:10.1093/eurheartj/ehy280</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Goff D.C. Jr, Lloyd-Jones D.M., Bennett G. et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(25 Suppl 2):S49-73. doi:10.1161/01.cir.0000437741.48606.98.</mixed-citation><mixed-citation xml:lang="en">Goff D.C. Jr, Lloyd-Jones D.M., Bennett G. et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 2014;129(25 Suppl 2):S49-73. doi:10.1161/01.cir.0000437741.48606.98.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Blood Pressure Lowering Treatment Trialists’ Collaboration. Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data. Lancet. 2014;384(9943):591-8. doi:10.1016/S0140-6736(14)61212-5.</mixed-citation><mixed-citation xml:lang="en">Blood Pressure Lowering Treatment Trialists’ Collaboration. Blood pressure-lowering treatment based on cardiovascular risk: a meta-analysis of individual patient data. Lancet. 2014;384(9943):591-8. doi:10.1016/S0140-6736(14)61212-5.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Lüscher T.F. What is a normal blood pressure? Eur Heart J. 2018;39(24):2233-40. doi:10.1093/eurheartj/ehy330.</mixed-citation><mixed-citation xml:lang="en">Lüscher T.F. What is a normal blood pressure? Eur Heart J. 2018;39(24):2233-40. doi:10.1093/eurheartj/ehy330.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Thomopoulos C., Parati G., Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension: 2. Effects at different baseline and achieved blood pressure levels--overview and metaanalyses of randomized trials. J Hypertens. 2014;32(12):2296-304. doi:10.1097/HJH.0000000000000379.</mixed-citation><mixed-citation xml:lang="en">Thomopoulos C., Parati G., Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension: 2. Effects at different baseline and achieved blood pressure levels--overview and metaanalyses of randomized trials. J Hypertens. 2014;32(12):2296-304. doi:10.1097/HJH.0000000000000379.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Brunström M., Carlberg В. Association of blood pressure lowering with mortality and cardiovascular disease across blood pressure levels: a systematic review and meta-analysis. JAMA Intern Med. 2018;178(1):28-36. doi:10.1001/jamainternmed.2017.6015.</mixed-citation><mixed-citation xml:lang="en">Brunström M., Carlberg В. Association of blood pressure lowering with mortality and cardiovascular disease across blood pressure levels: a systematic review and meta-analysis. JAMA Intern Med. 2018;178(1):28-36. doi:10.1001/jamainternmed.2017.6015.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Sundström J., Arima H., Jackson R. et al. Effects of blood pressure reduction in mild hypertension: a systematic review and meta-analysis. Ann Intern Med. 2015;162(3):184-91. doi:10.7326/M14- 0773.</mixed-citation><mixed-citation xml:lang="en">Sundström J., Arima H., Jackson R. et al. Effects of blood pressure reduction in mild hypertension: a systematic review and meta-analysis. Ann Intern Med. 2015;162(3):184-91. doi:10.7326/M14- 0773.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Julius S., Nesbitt S.D., Egan B.M. et al. Feasibility of treating prehypertension with an angiotensinreceptor blocker. N Engl J Med. 2006;354(16):1685-97. doi:10.1056/NEJMoa060838.</mixed-citation><mixed-citation xml:lang="en">Julius S., Nesbitt S.D., Egan B.M. et al. Feasibility of treating prehypertension with an angiotensinreceptor blocker. N Engl J Med. 2006;354(16):1685-97. doi:10.1056/NEJMoa060838.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Lüders S., Schrader J., Berger J. et al. The PHARAO study: prevention of hypertension with the angiotensin-converting enzyme inhibitor ramipril in patients with high-normal blood pressure: a prospective, randomized, controlled prevention trial of the German Hypertension League. J Hypertens. 2008;26(7):1487-96. doi:10.1097/HJH.0b013e3282ff8864.</mixed-citation><mixed-citation xml:lang="en">Lüders S., Schrader J., Berger J. et al. The PHARAO study: prevention of hypertension with the angiotensin-converting enzyme inhibitor ramipril in patients with high-normal blood pressure: a prospective, randomized, controlled prevention trial of the German Hypertension League. J Hypertens. 2008;26(7):1487-96. doi:10.1097/HJH.0b013e3282ff8864.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Fuchs S., Poli-de-Figueiredo C., Figueiredo Neto J. et al. Effectiveness of Chlorthalidone Plus Amiloride for the Prevention of Hypertension: The PREVER-Prevention Randomized Clinical Trial. J Am Heart Assoc. 2016;5:e004248. doi:10.1161/JAHA.116.004248.</mixed-citation><mixed-citation xml:lang="en">Fuchs S., Poli-de-Figueiredo C., Figueiredo Neto J. et al. Effectiveness of Chlorthalidone Plus Amiloride for the Prevention of Hypertension: The PREVER-Prevention Randomized Clinical Trial. J Am Heart Assoc. 2016;5:e004248. doi:10.1161/JAHA.116.004248.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Wald D.S., Law M., Morris J.K. et al. Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials. Am J Med. 2009;122(3):290-300. doi:10.1016/j.amjmed.2008.09.038.</mixed-citation><mixed-citation xml:lang="en">Wald D.S., Law M., Morris J.K. et al. Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials. Am J Med. 2009;122(3):290-300. doi:10.1016/j.amjmed.2008.09.038.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">MacDonald T.M., Williams B., Webb D.J. et al. Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: a double-blind randomized controlled trial. J Am Heart Assoc. 2017;6(11):pii: e006986. doi:10.1161/JAHA.117.006986.</mixed-citation><mixed-citation xml:lang="en">MacDonald T.M., Williams B., Webb D.J. et al. Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: a double-blind randomized controlled trial. J Am Heart Assoc. 2017;6(11):pii: e006986. doi:10.1161/JAHA.117.006986.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Gupta A.K., Arshad S., Poulter N.R. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis. Hypertension. 2010;55(2):399-407. doi:10.1161/HYPERTENSIONAHA.109.139816.</mixed-citation><mixed-citation xml:lang="en">Gupta A.K., Arshad S., Poulter N.R. Compliance, safety, and effectiveness of fixed-dose combinations of antihypertensive agents: a meta-analysis. Hypertension. 2010;55(2):399-407. doi:10.1161/HYPERTENSIONAHA.109.139816.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Xu W., Goldberg S.I., Shubina M., Turchin A. Optimal systolic blood pressure target, time to intensification, and time to follow-up in treatment of hypertension: population based retrospective cohort study. BMJ. 2015;350:h158. doi:10.1136/bmj.h158.</mixed-citation><mixed-citation xml:lang="en">Xu W., Goldberg S.I., Shubina M., Turchin A. Optimal systolic blood pressure target, time to intensification, and time to follow-up in treatment of hypertension: population based retrospective cohort study. BMJ. 2015;350:h158. doi:10.1136/bmj.h158.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Egan B.M., Bandyopadhyay D., Shaftman S.R. et al. Initial monotherapy and combination therapy and hypertension control the first year. Hypertension. 2012;59(6):1124-31. doi:10.1161/HYPERTENSIONAHA.112.194167.</mixed-citation><mixed-citation xml:lang="en">Egan B.M., Bandyopadhyay D., Shaftman S.R. et al. Initial monotherapy and combination therapy and hypertension control the first year. Hypertension. 2012;59(6):1124-31. doi:10.1161/HYPERTENSIONAHA.112.194167.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Jung O., Gechter J.L., Wunder C. et al. Resistant hypertension? Assessment of adherence by toxicological urine analysis. J Hypertens. 2013;31(4):766-74. doi:10.1097/HJH.0b013e32835e2286.</mixed-citation><mixed-citation xml:lang="en">Jung O., Gechter J.L., Wunder C. et al. Resistant hypertension? Assessment of adherence by toxicological urine analysis. J Hypertens. 2013;31(4):766-74. doi:10.1097/HJH.0b013e32835e2286.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Conn V.S., Ruppar T.M., Chase J.A. et al. Interventions to improve medication adherence in hypertensive patients: systematic review and meta-analysis. Curr Hypertens Rep. 2015;17(12):94. doi:10.1007/s11906-015-0606-5.</mixed-citation><mixed-citation xml:lang="en">Conn V.S., Ruppar T.M., Chase J.A. et al. Interventions to improve medication adherence in hypertensive patients: systematic review and meta-analysis. Curr Hypertens Rep. 2015;17(12):94. doi:10.1007/s11906-015-0606-5.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Corrao G., Parodi A., Zambon A. et al. Reduced discontinuation of antihypertensive treatment by two-drug combination as first step. Evidence from daily life practice. J Hypertens. 2010;28(7):1584- 90. doi:10.1097/HJH.0b013e328339f9fa.</mixed-citation><mixed-citation xml:lang="en">Corrao G., Parodi A., Zambon A. et al. Reduced discontinuation of antihypertensive treatment by two-drug combination as first step. Evidence from daily life practice. J Hypertens. 2010;28(7):1584- 90. doi:10.1097/HJH.0b013e328339f9fa.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Thomopoulos C., Parati G., Zanchetti A. Effects of blood-pressure-lowering treatment in hypertension: 9. Discontinuations for adverse events attributed to different classes of antihypertensive drugs: metaanalyses of randomized trials. J Hypertens. 2016;34(10):1921-32. doi:10.1097/HJH.0000000000001052.</mixed-citation><mixed-citation xml:lang="en">Thomopoulos C., Parati G., Zanchetti A. Effects of blood-pressure-lowering treatment in hypertension: 9. Discontinuations for adverse events attributed to different classes of antihypertensive drugs: metaanalyses of randomized trials. J Hypertens. 2016;34(10):1921-32. doi:10.1097/HJH.0000000000001052.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Lonn E.M., Bosch J., López-Jaramillo P. et al. Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease. N Engl J Med. 2016;374(21):2009-20. doi:10.1056/NEJMoa1600175.</mixed-citation><mixed-citation xml:lang="en">Lonn E.M., Bosch J., López-Jaramillo P. et al. Blood-Pressure Lowering in Intermediate-Risk Persons without Cardiovascular Disease. N Engl J Med. 2016;374(21):2009-20. doi:10.1056/NEJMoa1600175.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Thomopoulos C., Parati G., Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension. 1. Overview, meta-analyses, and meta-regression analyses of randomized trials. J Hypertens. 2014;32(12):2285-95. doi:10.1097/HJH.0000000000000378.</mixed-citation><mixed-citation xml:lang="en">Thomopoulos C., Parati G., Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension. 1. Overview, meta-analyses, and meta-regression analyses of randomized trials. J Hypertens. 2014;32(12):2285-95. doi:10.1097/HJH.0000000000000378.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Thomopoulos C., Parati G., Zanchetti A. Effects of blood pressure-lowering treatment. 6. Prevention of heart failure and new-onset heart failure – meta-analyses of randomized trials. J Hypertens. 2016;34(3):373-84. doi:10.1097/HJH.0000000000000848.</mixed-citation><mixed-citation xml:lang="en">Thomopoulos C., Parati G., Zanchetti A. Effects of blood pressure-lowering treatment. 6. Prevention of heart failure and new-onset heart failure – meta-analyses of randomized trials. J Hypertens. 2016;34(3):373-84. doi:10.1097/HJH.0000000000000848.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Thomopoulos C., Parati G., Zanchetti A. Effects of blood pressure-lowering on outcome incidence in hypertension: 5. Head-to-head comparisons of various classes of antihypertensive drugs – overview and meta-analyses. J Hypertens. 2015;33(7):1321-41. doi:10.1097/HJH.0000000000000614.</mixed-citation><mixed-citation xml:lang="en">Thomopoulos C., Parati G., Zanchetti A. Effects of blood pressure-lowering on outcome incidence in hypertension: 5. Head-to-head comparisons of various classes of antihypertensive drugs – overview and meta-analyses. J Hypertens. 2015;33(7):1321-41. doi:10.1097/HJH.0000000000000614.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Böhm M., Schumacher H., Teo K.K. et al. Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials. Lancet. 2017;389(10085):2226-37. doi:10.1016/S0140-6736(17)30754-7.</mixed-citation><mixed-citation xml:lang="en">Böhm M., Schumacher H., Teo K.K. et al. Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials. Lancet. 2017;389(10085):2226-37. doi:10.1016/S0140-6736(17)30754-7.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Kjeldsen S.E., Berge E., Bangalore S. et al. No evidence for a J-shaped curve in treated hypertensive patients with increased cardiovascular risk: The VALUE trial. Blood Press. 2016;25(2):83-92. doi:10.3109/08037051.2015.1106750.</mixed-citation><mixed-citation xml:lang="en">Kjeldsen S.E., Berge E., Bangalore S. et al. No evidence for a J-shaped curve in treated hypertensive patients with increased cardiovascular risk: The VALUE trial. Blood Press. 2016;25(2):83-92. doi:10.3109/08037051.2015.1106750.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Mancia G., Kjeldsen S.E., Zappe D.H. et al. Cardiovascular outcomes at different on-treatment blood pressures in the hypertensive patients of the VALUE trial. Eur Heart J. 2016;37(12):955-64. doi:10.1093/eurheartj/ehv633.</mixed-citation><mixed-citation xml:lang="en">Mancia G., Kjeldsen S.E., Zappe D.H. et al. Cardiovascular outcomes at different on-treatment blood pressures in the hypertensive patients of the VALUE trial. Eur Heart J. 2016;37(12):955-64. doi:10.1093/eurheartj/ehv633.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Bundy J.D., Li C., Stuchlik P. et al. Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis. JAMA Cardiol. 2017;2(7):775-81. doi:10.1001/jamacardio.2017.1421.</mixed-citation><mixed-citation xml:lang="en">Bundy J.D., Li C., Stuchlik P. et al. Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis. JAMA Cardiol. 2017;2(7):775-81. doi:10.1001/jamacardio.2017.1421.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Xie X., Atkins E., Lv J. et al. Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis. Lancet. 2016;387(10017):435-43. doi:10.1016/S0140-6736(15)00805-3.</mixed-citation><mixed-citation xml:lang="en">Xie X., Atkins E., Lv J. et al. Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis. Lancet. 2016;387(10017):435-43. doi:10.1016/S0140-6736(15)00805-3.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Bangalore S., Toklu B., Gianos E. et al. Optimal systolic blood pressure target after SPRINT: insights from a network meta-analysis of randomized trials. Am J Med. 2017;130(6):707-19.e8. doi:10.1016/j.amjmed.2017.01.004.</mixed-citation><mixed-citation xml:lang="en">Bangalore S., Toklu B., Gianos E. et al. Optimal systolic blood pressure target after SPRINT: insights from a network meta-analysis of randomized trials. Am J Med. 2017;130(6):707-19.e8. doi:10.1016/j.amjmed.2017.01.004.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Verdecchia P., Angeli F., Gentile G., Reboldi G. More versus less intensive blood pressure-lowering strategy: cumulative evidence and trial sequential analysis. Hypertension. 2016;68(3):642-53. doi:10.1161/HYPERTENSIONAHA.116.07608.</mixed-citation><mixed-citation xml:lang="en">Verdecchia P., Angeli F., Gentile G., Reboldi G. More versus less intensive blood pressure-lowering strategy: cumulative evidence and trial sequential analysis. Hypertension. 2016;68(3):642-53. doi:10.1161/HYPERTENSIONAHA.116.07608.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Thomopoulos C., Parati G., Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension: 7. Effects of more vs. less intensive blood pressure lowering and different achieved blood pressure levels - updated overview and meta-analyses of randomized trials. J Hypertens. 2016;34(4):613-22. doi:10.1097/HJH.0000000000000881.</mixed-citation><mixed-citation xml:lang="en">Thomopoulos C., Parati G., Zanchetti A. Effects of blood pressure lowering on outcome incidence in hypertension: 7. Effects of more vs. less intensive blood pressure lowering and different achieved blood pressure levels - updated overview and meta-analyses of randomized trials. J Hypertens. 2016;34(4):613-22. doi:10.1097/HJH.0000000000000881.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Ettehad D., Emdin C.A., Kiran A. et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. 2016;387(10022):957-67. doi:10.1016/S0140-6736(15)01225-8.</mixed-citation><mixed-citation xml:lang="en">Ettehad D., Emdin C.A., Kiran A. et al. Blood pressure lowering for prevention of cardiovascular disease and death: a systematic review and meta-analysis. Lancet. 2016;387(10022):957-67. doi:10.1016/S0140-6736(15)01225-8.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">SPRINT Research Group, Wright J.T. Jr, Williamson J..D, Whelton P.K. et al. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373(22):2103-16. doi:10.1056/NEJMoa1511939.</mixed-citation><mixed-citation xml:lang="en">SPRINT Research Group, Wright J.T. Jr, Williamson J..D, Whelton P.K. et al. A randomized trial of intensive versus standard blood-pressure control. N Engl J Med. 2015;373(22):2103-16. doi:10.1056/NEJMoa1511939.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Williamson J.D., Supiano M.A., Applegate W.B. et al. Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged ≥75 years: a randomized clinical trial. JAMA. 2016;315(24):2673-82. doi:10.1001/jama.2016.7050</mixed-citation><mixed-citation xml:lang="en">Williamson J.D., Supiano M.A., Applegate W.B. et al. Intensive vs standard blood pressure control and cardiovascular disease outcomes in adults aged ≥75 years: a randomized clinical trial. JAMA. 2016;315(24):2673-82. doi:10.1001/jama.2016.7050</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Odden M.C., Peralta C.A., Berlowitz D.R. et al. Effect of intensive blood pressure control on gait speed and mobility limitation in adults 75 years or older: a randomized clinical trial. JAMA Intern Med. 2017;177(4):500-7. doi:10.1001/jamainternmed.2016.9104.</mixed-citation><mixed-citation xml:lang="en">Odden M.C., Peralta C.A., Berlowitz D.R. et al. Effect of intensive blood pressure control on gait speed and mobility limitation in adults 75 years or older: a randomized clinical trial. JAMA Intern Med. 2017;177(4):500-7. doi:10.1001/jamainternmed.2016.9104.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Johnson K.C., Whelton P.K., Cushman W.C. et al. Blood pressure measurement in SPRINT (Systolic Blood Pressure Intervention Trial). Hypertension. 2018;71(5):848-57. doi:10.1161/HYPERTENSIONAHA.117.10479.</mixed-citation><mixed-citation xml:lang="en">Johnson K.C., Whelton P.K., Cushman W.C. et al. Blood pressure measurement in SPRINT (Systolic Blood Pressure Intervention Trial). Hypertension. 2018;71(5):848-57. doi:10.1161/HYPERTENSIONAHA.117.10479.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Kjeldsen S.E., Lund-Johansen P., Nilsson P.M., Mancia G. Unattended blood pressure measurements in the Systolic Blood Pressure Intervention trial: implications for entry and achieved blood pressure values compared with other trials. Hypertension. 2016;67:808-12. doi:10.1161/HYPERTENSION - AHA.116.07257.</mixed-citation><mixed-citation xml:lang="en">Kjeldsen S.E., Lund-Johansen P., Nilsson P.M., Mancia G. Unattended blood pressure measurements in the Systolic Blood Pressure Intervention trial: implications for entry and achieved blood pressure values compared with other trials. Hypertension. 2016;67:808-12. doi:10.1161/HYPERTENSION - AHA.116.07257.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Kjeldsen S.E., Mancia G. Unobserved automated office blood pressure measurement in the Systolic Blood Pressure Intervention Trial (SPRINT): systolic blood pressure treatment target remains below 140 mmHg. Eur Heart J Cardiovasc Pharmacother. 2016;2(2):79-80. doi:10.1093/ehjcvp/pvw002.</mixed-citation><mixed-citation xml:lang="en">Kjeldsen S.E., Mancia G. Unobserved automated office blood pressure measurement in the Systolic Blood Pressure Intervention Trial (SPRINT): systolic blood pressure treatment target remains below 140 mmHg. Eur Heart J Cardiovasc Pharmacother. 2016;2(2):79-80. doi:10.1093/ehjcvp/pvw002.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Горбунов В.М. Проблемы оценки результатов измерения артериального давления в современных клинических исследованиях (на примере исследования SPRINT). Рациональная Фармакотерапия в Кардиологии. 2018;14(1):122-30. doi:10.20996/1819-6446-2018-14-1-122-130.</mixed-citation><mixed-citation xml:lang="en">Gorbunov V.M. Problems of Evaluating Blood Pressure Measurement in Modern Clinical Trials (the case of SPRINT Study Results). Rational Pharmacotherapy in Cardiology. 2018;14(1):122-30. (In Russ.) doi:10.20996/1819-6446-2018-14-1-122-130.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Vidal-Petiot E., Elbez Y., Lüscher T.F. et al. The 2018 ESC-ESH guidelines for the management of arterial hypertension leave clinicians facing a dilemma in half of the patients. Eur Heart J. 2018;39(45):4040-1. doi:10.1093/eurheartj/ehy495.</mixed-citation><mixed-citation xml:lang="en">Vidal-Petiot E., Elbez Y., Lüscher T.F. et al. The 2018 ESC-ESH guidelines for the management of arterial hypertension leave clinicians facing a dilemma in half of the patients. Eur Heart J. 2018;39(45):4040-1. doi:10.1093/eurheartj/ehy495.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Thomopoulos C., Parati G., Zanchetti A. Effects of blood pressure-lowering treatment on cardiovascular outcomes and mortality: 13 - benefits and adverse events in older and younger patients with hypertension: overview, meta-analyses and meta-regression analyses of randomized trials. J Hypertens. 2018;36(8):1622-36. doi:10.1097/HJH.0000000000001787.</mixed-citation><mixed-citation xml:lang="en">Thomopoulos C., Parati G., Zanchetti A. Effects of blood pressure-lowering treatment on cardiovascular outcomes and mortality: 13 - benefits and adverse events in older and younger patients with hypertension: overview, meta-analyses and meta-regression analyses of randomized trials. J Hypertens. 2018;36(8):1622-36. doi:10.1097/HJH.0000000000001787.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Bavishi C., Bangalore S., Messerli F.H. Outcomes of intensive blood pressure lowering in older hypertensive patients. J Am Coll Cardiol. 2017;69(5):486-93. doi:10.1016/j.jacc.2016.10.077.</mixed-citation><mixed-citation xml:lang="en">Bavishi C., Bangalore S., Messerli F.H. Outcomes of intensive blood pressure lowering in older hypertensive patients. J Am Coll Cardiol. 2017;69(5):486-93. doi:10.1016/j.jacc.2016.10.077.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Stamler J., Stamler R., Neaton J.D. Blood pressure, systolic and diastolic, and cardiovascular risks. US population data. Arch Intern Med. 1993;153(5):598-615.</mixed-citation><mixed-citation xml:lang="en">Stamler J., Stamler R., Neaton J.D. Blood pressure, systolic and diastolic, and cardiovascular risks. US population data. Arch Intern Med. 1993;153(5):598-615.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Guo X., Zhang X, Guo L. et al. Association between pre-hypertension and cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Curr Hypertens Rep. 2013;15(6):703- 16. doi:10.1007/s11906-013-0403-y.</mixed-citation><mixed-citation xml:lang="en">Guo X., Zhang X, Guo L. et al. Association between pre-hypertension and cardiovascular outcomes: a systematic review and meta-analysis of prospective studies. Curr Hypertens Rep. 2013;15(6):703- 16. doi:10.1007/s11906-013-0403-y.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Huang Y., Cai X., Zhang J. et al. Prehypertension and Incidence of ESRD: a systematic review and meta-analysis. Am J Kidney Dis. 2014;63(1):76-83. doi:10.1053/j.ajkd.2013.07.024.</mixed-citation><mixed-citation xml:lang="en">Huang Y., Cai X., Zhang J. et al. Prehypertension and Incidence of ESRD: a systematic review and meta-analysis. Am J Kidney Dis. 2014;63(1):76-83. doi:10.1053/j.ajkd.2013.07.024.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Lee M., Saver J.L., Chang B. et al. Presence of baseline prehypertension and risk of incident stroke: a meta-analysis. Neurology. 2011;77(14):1330-7. doi:10.1212/WNL.0b013e3182315234.</mixed-citation><mixed-citation xml:lang="en">Lee M., Saver J.L., Chang B. et al. Presence of baseline prehypertension and risk of incident stroke: a meta-analysis. Neurology. 2011;77(14):1330-7. doi:10.1212/WNL.0b013e3182315234.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Shen L., Ma H., Xiang M.X., Wang J.A. Meta-analysis of cohort studies of baseline prehypertension and risk of coronary heart disease. Am J Cardiol. 2013;112(2):266-71. doi:10.1016/j.amjcard.2013.03.023.</mixed-citation><mixed-citation xml:lang="en">Shen L., Ma H., Xiang M.X., Wang J.A. Meta-analysis of cohort studies of baseline prehypertension and risk of coronary heart disease. Am J Cardiol. 2013;112(2):266-71. doi:10.1016/j.amjcard.2013.03.023.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Böhm M., Schumacher H., Teo K.K. et al. Achieved diastolic blood pressure and pulse pressure at target systolic blood pressure (120-140 mmHg) and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials. Eur Heart J. 2018;39(33):3105-14. doi:10.1093/eurheartj/ehy287.</mixed-citation><mixed-citation xml:lang="en">Böhm M., Schumacher H., Teo K.K. et al. Achieved diastolic blood pressure and pulse pressure at target systolic blood pressure (120-140 mmHg) and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials. Eur Heart J. 2018;39(33):3105-14. doi:10.1093/eurheartj/ehy287.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Beddhu S., Rocco M.V., Toto R. et al. Effects of Intensive Systolic Blood Pressure Control on Kidney and Cardiovascular Outcomes in Persons Without Kidney Disease: A Secondary Analysis of a Randomized Trial. Ann Intern Med. 2017;167(6):375-83. doi:10.7326/M16-2966.</mixed-citation><mixed-citation xml:lang="en">Beddhu S., Rocco M.V., Toto R. et al. Effects of Intensive Systolic Blood Pressure Control on Kidney and Cardiovascular Outcomes in Persons Without Kidney Disease: A Secondary Analysis of a Randomized Trial. Ann Intern Med. 2017;167(6):375-83. doi:10.7326/M16-2966.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Cheung A.K., Rahman M., Reboussin D.M. et al. Effects of Intensive BP Control in CKD. J Am Soc Nephrol. 2017;28(9):2812-23. doi:10.1681/ASN.2017020148.</mixed-citation><mixed-citation xml:lang="en">Cheung A.K., Rahman M., Reboussin D.M. et al. Effects of Intensive BP Control in CKD. J Am Soc Nephrol. 2017;28(9):2812-23. doi:10.1681/ASN.2017020148.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
