rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2019-15-3-407-415rpcardio-1964Research ArticleINNOVATIVE CARDIOLOGYИННОВАЦИОННАЯ КАРДИОЛОГИЯGenetic, Epigenetic and Transcription Factors in Atrial FibrillationЗначение генетических, эпигенетических факторов и факторов транскрипции в фибрилляции предсердийСапельниковО. В.SapelnikovO. V.

д.м.н, н.с., отдел сердечно-сосудистой хирургии

Россия, 121552, Москва, 3-я Черепковская ул., 15а

MD, PhD, Researcher, Department of Cardiovascular Surgery

Tretya Cherepkovskaya ul. 15а, Moscow, 121552 Russia

КуликовА. А.KulikovA. A.

м.н.с., отдел сердечно-сосудистой хирургии

Россия, 121552, Москва, 3-я Черепковская ул., 15а

Junior Researcher, Department of Cardiovascular Surgery

Tretya Cherepkovskaya ul. 15а, Moscow, 121552 Russia

Zeart@mail.ruФавороваО. О.FavorovaO. O.

д.б.н., профессор, руководитель лаборатории функциональной геномики сердечно-сосудистых заболеваний; зав. кафедрой молекулярной биологии и медицинской биотехнологии

Россия, 121552, Москва, 3-я Черепковская ул., 15а

Россия, 117997, Москва, ул. Островитянова, 1

 

PhD (Biology), Professor, Head of Laboratory of Functional Genomics of Cardiovascular Diseases; Head of Chair of Molecular Biology and Medical Biotechnology

Tretya Cherepkovskaya ul. 15а, Moscow, 121552 Russia

Ostrovitianova ul. 1, Moscow, 117997 Russia

МатвееваН. А.MatveevaN. A.

к.б.н., н.с., лаборатория функциональной геномики сердечно-сосудистых заболеваний; н.с., кафедра молекулярной биологиии медицинской биотехнологии

Россия, 121552, Москва, 3-я Черепковская ул., 15а

Россия, 117997, Москва, ул. Островитянова, 1

PhD (Biology), Researcher, Laboratory of Functional Genomics of Cardiovascular Diseases; Researcher, Chair of Molecular Biology and Medical Biotechnology

Tretya Cherepkovskaya ul. 15а, Moscow, 121552 Russia

Ostrovitianova ul. 1, Moscow, 117997 Russia

ЧеркашинД. И.CherkashinD. I.

к.м.н., врач сердечно-сосудистый хирург, отдел сердечно-сосудистойхирургии

Россия, 121552, Москва, 3-я Черепковская ул., 15а

MD, PhD, Cardiovascular Surgeon, Department of Cardiovascular Surgery

Tretya Cherepkovskaya ul. 15а, Moscow, 121552 Russia

НиколаеваО. А.NikolaevaO. A.

м.н.с., лаборатория хирургических и рентгенхирургических методов лечения нарушений ритма сердца, отдел сердечно-сосудистой  хирургии

Россия, 121552, Москва, 3-я Черепковская ул., 15а

Junior Researcher, Laboratory of Surgical and X-ray Surgery for the Treatment of Cardiac Arrhythmias, Department of Cardiovascular Surgery

Tretya Cherepkovskaya ul. 15а, Moscow, 121552 Russia

АкчуринР. С.AkchurinR. S.

академик РАН, д.м.н., профессор, руководитель отдела сердечно-сосудистой хирургии, зам. генерального директора по хирургии

Россия, 121552, Москва, 3-я Черепковская ул., 15а

MD, PhD, Professor, Academician of the Russian Academy of Sciences, Head of Department of Cardiovascular Surgery, Deputy General Director for Surgery

Tretya Cherepkovskaya ul. 15а, Moscow, 121552 Russia

Национальный медицинский исследовательский центр кардиологииРоссияNational Medical Research Center of CardiologyRussian FederationНациональный медицинский исследовательский центр кардиологии Российский национальный исследовательский медицинский университет им. Н. И. ПироговаРоссияNational Medical Research Center of Cardiology Pirogov Russian National Research Medical UniversityRussian Federation201903072019153407415Copyright © Sapelnikov O.V., Kulikov A.A., Favorova O.O., Matveeva N.A., Cherkashin D.I., Nikolaeva O.A., Akchurin R.S., 20192019Сапельников О.В., Куликов А.А., Фаворова О.О., Матвеева Н.А., Черкашин Д.И., Николаева О.А., Акчурин Р.С.Sapelnikov O.V., Kulikov A.A., Favorova O.O., Matveeva N.A., Cherkashin D.I., Nikolaeva O.A., Akchurin R.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/1964

Atrial fibrillation (AF) is one of the most common arrhythmia that occurs in patients with cardiovascular diseases. Congenital forms of AF are quite rare. Many studies have shown that genetic, epigenetic and transcription factors may play an important role in the development and the progression of AF. In our review, studies have been conducted on the identification of mutations in ionic and non-ionic channels, possibly associated with AF. These mutations were found only in isolated groups of patients with AF, and in general, monogenic forms of AF are a rare subtype of the disease. Genomic association studies have helped to identify potential links between single nucleotide polymorphisms and AF. The risk of AF in the general population is likely to be determined by the interaction between environmental factors and many alleles. In recent years, the emergence of a genome-wide associative studies has significantly expanded the understanding of the genetic basis for the inheritance of AF and has led to the emergence of new evidence of the important role of genetic factors in the development of AF, in the risk stratification of AF and the recurrence of AF. Epigenetic factors are also important in AF. Epigenetic therapy aimed at treating a disease through exposure to epigenome is currently under development. A newly emerged area of ablatogenomics includes the use of genetic profiles that allow assessing the likelihood of recurrence of AF after catheter ablation. The results of genetic studies in AF show that, in addition to their role in the appearance of congenital heart pathologies, transcription factors play an important role in the pathogenesis of AF.

Одной из самых распространенных аритмий, возникающих у пациентов с сердечно-сосудистыми заболеваниями, является фибрилляция предсердий (ФП). Врожденные формы ФП достаточно редки. Многие исследования показали, что генетические, эпигенетические факторы и факторы транскрипции могут играть важную роль в возникновении и прогрессировании ФП. В нашем обзоре проведено изучение работ, посвященных выявлению мутаций ионных и не ионных каналов, возможно, связанных с ФП. Эти мутации были обнаружены только в изолированных группах пациентов с ФП, и в целом моногенные формы ФП представляют собой редкий подтип заболевания. Исследования геномных ассоциаций помогли определить потенциальные связи между однонуклеотидными полиморфизмами и ФП. Риск развития ФП в общей популяции, вероятно, определяется взаимодействием между факторами среды и множеством аллелей. В последние годы появление полногеномного ассоциативного сканирования существенно расширило понимание генетических основ наследования ФП и привело к появлению новых доказательств важной роли генетических факторов в развитии ФП, в стратификации риска ФП и рецидиве ФП. Эпигенетические факторы также имеют большое значение при ФП. В настоящее время разрабатывается эпигенетическая терапия, направленная на лечение заболевания посредством воздействия на эпигеном. Недавно возникшая область аблатогеномики включает использование генетических профилей, позволяющих оценить возможность возникновения рецидива ФП после катетерной абляции. Результаты генетических исследований при ФП показывают, что, помимо роли в появлении врожденных патологий сердца, факторы транскрипции играют важную роль в патогенезе ФП.

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The authors declare that there are no conflicts of interest present.