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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2019-15-4-478-483</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-1998</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group></article-categories><title-group><article-title>The Association of Smoking Status and Intensity of Smoking with Blood Lipid Spectrum in a Sample of Middle-Aged Men</article-title><trans-title-group xml:lang="ru"><trans-title>Ассоциация курительного статуса и интенсивности курения с липидным спектром крови в выборке мужчин среднего возраста</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Александров</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Alexandrov</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Александров Александр Александрович – д.м.н., профессор, руководитель лаборатории профилактики хронических неинфекционных заболеваний у детей и подростков, отдел первичной профилактики хронических неинфекционных заболеваний в системе здравоохранения, НМИЦ ПМ</p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>Alexander A. Alexandrov – MD, PhD, Professor, Head of the Laboratory for the Prevention of Chronic Non-Communicable Diseases in Children and Adolescents, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Health System</p><p>Petroverigsky per. 10, Moscow, 101990 Russia</p></bio><email xlink:type="simple">aalexandrov@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Розанов</surname><given-names>В. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Rozanov</surname><given-names>V. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Розанов Вячеслав Борисович – д.м.н., в.н.с., лаборатория профилактики хронических неинфекционных заболеваний у детей и подростков, отдел первичной профилактики хронических неинфекционных заболеваний в системе здравоохранения, НМИЦ ПМ</p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>Vyatcheslav B. Rozanov – MD, PhD, Leading Researcher, Laboratory for the Prevention of Chronic Non-Communicable Diseases in Children and Adolescents, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Health System</p><p>Petroverigsky per. 10, Moscow, 101990 Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Котова</surname><given-names>М. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Kotova</surname><given-names>M. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Котова Марина Борисовна – к.п.н., в.н.с., лаборатория профилактики хронических неинфекционных заболеваний у детей и подростков, отдел первичной профилактики хронических неинфекционных заболеваний в системе здравоохранения, НМИЦ ПМ</p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>Marina B. Kotova – PhD (Psychology), Leading Researcher, Laboratory for the Prevention of Chronic Non-Communicable Diseases in Children and Adolescents, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Health System</p><p>Petroverigsky per. 10, Moscow, 101990 Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дадаева</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Dadaeva</surname><given-names>V. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Дадаева Валида Арсланалиевна – к.м.н., н.с., лаборатория профилактики хронических неинфекционных заболеваний у детей и подростков, отдел первичной профилактики хронических неинфекционных заболеваний в системе здравоохранения, НМИЦ ПМ</p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>Valida A. Dadaeva – MD, PhD, Researcher, Laboratory of the Chronic Non-Communicable Diseases of Children and Adolescents, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Health System</p><p>Petroverigsky per. 10, Moscow, 101990 Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Иванова</surname><given-names>Е. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Ivanova</surname><given-names>E. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Иванова Елена Ильинична – н.с., лаборатория профилактики хронических неинфекционных заболеваний у детей и подростков, отдел первичной профилактики хронических неинфекционных заболеваний в системе здравоохранения, НМИЦ ПМ</p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>Elena I. Ivanova – MD, Researcher, Laboratory for the Prevention of Chronic Non-Communicable Diseases in Children and Adolescents, Department of Primary Prevention of Chronic Non-Communicable Diseases in the Health System</p><p>Petroverigsky per. 10, Moscow, 101990 Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр профилактической медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Preventive Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>01</day><month>09</month><year>2019</year></pub-date><volume>15</volume><issue>4</issue><fpage>478</fpage><lpage>483</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Alexandrov A.A., Rozanov V.B., Kotova M.B., Dadaeva V.A., Ivanova E.I., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Александров А.А., Розанов В.Б., Котова М.Б., Дадаева В.А., Иванова Е.И.</copyright-holder><copyright-holder xml:lang="en">Alexandrov A.A., Rozanov V.B., Kotova M.B., Dadaeva V.A., Ivanova E.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/1998">https://www.rpcardio.online/jour/article/view/1998</self-uri><abstract><sec><title>Material and methods</title><p>Material and methods. A 32-year prospective cohort follow-up of males from childhood (11-12 years) was carried out. After 32 years of 1005 participants 301 (30.0%) were examined. The survey included: a survey on a standard questionnaire (passport data, the presence of bad habits [smoking, alcohol consumption]), a three-time measurement of blood pressure. The levels of total cholesterol, high and low density lipoprotein cholesterol, triglycerides were determined.</p></sec><sec><title>Results</title><p>Results. There is no established relationship between the average level of total cholesterol and hypercholesterolemia with smoking status and smoking intensity. It is shown that the level of triglycerides is statistically significantly higher in smokers as compared to non-smokers. Hypertriglyceridemia was not associated with smoking status, but was associated with the smoking index in current smokers, and only with the highest values of this index in past smokers. The probability of being in a group with dyslipidemia was more than 2 times higher in smokers as compared to non-smokers. The differences in the chances of getting into a group with dyslipidemia between smokers and nonsmokers in the past were statistically insignificant. The linear dependence of the frequency of dyslipidemia on the intensity of smoking at the present time, i.e. with increasing intensity of smoking increases the frequency of dyslipidemia. Such a dependence between smoking in the past and the frequency of dyslipidemia was not revealed. The probability of being in a group with a high atherogenic risk is 2 times higher in both smokers at present and smokers in the past as compared to non-smokers. The linear dependence of the frequency of high atherogenic risk on the intensity of smoking both now and in the past is established, i.e. with the increase in the intensity of smoking the frequency of high atherogenic risk increases in both smokers at present and smokers in the past as compared to non-smokers.</p></sec><sec><title>Conclusion</title><p>Conclusion. Close association of smoking with dyslipidemia was confirmed. The high probability of being in a group with a high atherogenic risk not only in smokers at present, but also smokers in the past indicates the importance of not only secondary, but also primary prevention of smoking.</p></sec></abstract><trans-abstract xml:lang="ru"><sec><title>Цель</title><p>Цель. Оценить связь курительного статуса и интенсивности курения с нарушениями липидного спектра крови в выборке мужчин среднего возраста.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Проведено 32-летнее проспективное когортное наблюдение за лицами мужского пола, начиная с детского возраста (11-12 лет). Через 32 года из 1005 участников исследования обследованы 301 (30,0%). Обследование включало: опрос по стандартной анкете (паспортные данные, наличие вредных привычек [курения, употребления алкоголя]), трехкратное измерение артериального давления. Определяли уровни общего холестерина, холестерина липопротеинов высокой и низкой плотности, триглицеридов.</p></sec><sec><title>Результаты</title><p>Результаты. Не установлена зависимость между средним уровнем общего холестерина и гиперхолестеринемией со статусом курения и интенсивностью курения. Показано, что уровень триглицеридов статистически достоверно выше у курящих в настоящее время по сравнению с некурящими. Гипертриглицеридемия не была связана со статусом курения, но была связана с индексом курения человека у лиц, курящих в настоящее время, и только с наиболее высокими значениями этого индекса у куривших в прошлом. Вероятность оказаться в группе с дислипедемией была выше более чем в 2 раза у курящих в настоящее время по сравнению с некурящими мужчинами. Различия в шансах попасть в группу с дислипидемией между некурящими и курившими в прошлом статистически незначимы. Установлена линейная зависимость частоты дислипидемии от интенсивности курения в настоящее время, т.е. с увеличением интенсивности курения в настоящее время увеличивается частота дислипидемии. Такой зависимости между курением в прошлом и частотой дислипидемии не выявлено. Вероятность оказаться в группе с высоким атерогенным риском выше в 2 раза как у курящих в настоящее время, так и куривших в прошлом по сравнению с некурящими мужчинами. Установлена линейная зависимость частоты высокого атерогенного риска от интенсивности курения как в настоящее время, так и в прошлом, т.е. с увеличением интенсивности курения увеличивается частота высокого атерогенного риска как у курящих в настоящее время, так и куривших в прошлом, по сравнению с некурящими мужчинами.</p></sec><sec><title>Заключение</title><p>Заключение. Подтверждена тесная связь курения с дислипидемией. Высокая вероятность оказаться в группе с высоким атерогенным риском не только у курящих в настоящее время, но и куривших в прошлом говорит о важности не только вторичной, но и первичной профилактики курения.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>частота курения</kwd><kwd>мужчины</kwd><kwd>факторы риска сердечно-сосудистых заболеваний</kwd><kwd>дислипопротеидемия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>smoking rate</kwd><kwd>men</kwd><kwd>risk factors for cardiovascular diseases</kwd><kwd>dyslipoproteidemia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Global Adult Tobacco Survey, Russian Federation, 2016, Executive summary [cited by Aug 01, 2019]. 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