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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2019-15-5-725-735</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-2044</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group></article-categories><title-group><article-title>The Role of Magnesium in the Development of Cardiovascular Diseases and the Possibility of their Prevention and Correction with Magnesium Preparations (Part 1)</article-title><trans-title-group xml:lang="ru"><trans-title>Роль магния в развитии сердечно-сосудистой патологии и возможности ее предотвращения и коррекции препаратами магния (Часть 1)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сафарян</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Safaryan</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., в.н.с., отдел профилактики метаболических нарушений,</p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>MD, PhD, Leading Researcher, Department of Metabolic Disorders Prevention, </p><p>Petroverigsky per. 10, Moscow, 101990</p></bio><email xlink:type="simple">ASafaryan@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Саргсян</surname><given-names>В. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Sargsyan</surname><given-names>V. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., с.н.с., отдел профилактики метаболических нарушений,</p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>MD, PhD, Senior Researcher, Department of Metabolic Disorders Prevention,</p><p>Petroverigsky per. 10, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Камышова</surname><given-names>Т. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kamyshova</surname><given-names>T. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., с.н.с., отдел профилактики метаболических нарушений, </p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>MD, PhD, Senior Researcher, Department of Metabolic Disorders Prevention,</p><p>Petroverigsky per. 10, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ахмеджанов</surname><given-names>Н. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Akhmedzhanov</surname><given-names>N. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., в.н.с., отдел профилактики метаболических нарушений, </p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>MD, PhD, Leading Researcher, Department of Metabolic Disorders Prevention, </p><p>Petroverigsky per. 10, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Небиеридзе</surname><given-names>Д. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nebieridze</surname><given-names>D. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, руководитель отдела профилактики метаболических нарушений, </p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>MD, PhD, Professor, Head of Department of Metabolic Disorders Prevention, </p><p>Petroverigsky per. 10, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Поддубская</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Poddubskaya</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., руководитель научно-организационного отдела,</p><p>101990, Москва, Петроверигский пер., 10</p></bio><bio xml:lang="en"><p>MD, PhD, Head of Scientific and Organizational Department,</p><p>Petroverigsky per. 10, Moscow, 101990</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр профилактической медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Preventive Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>06</day><month>11</month><year>2019</year></pub-date><volume>15</volume><issue>5</issue><fpage>725</fpage><lpage>735</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Safaryan A.S., Sargsyan V.S., Kamyshova T.V., Akhmedzhanov N.M., Nebieridze D.V., Poddubskaya E.A., 2019</copyright-statement><copyright-year>2019</copyright-year><copyright-holder xml:lang="ru">Сафарян А.С., Саргсян В.Д., Камышова Т.В., Ахмеджанов Н.М., Небиеридзе Д.В., Поддубская Е.А.</copyright-holder><copyright-holder xml:lang="en">Safaryan A.S., Sargsyan V.S., Kamyshova T.V., Akhmedzhanov N.M., Nebieridze D.V., Poddubskaya E.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/2044">https://www.rpcardio.online/jour/article/view/2044</self-uri><abstract><p>The article is devoted to the influence of magnesium on the homeostasis of the body and, in particular, on the cardiovascular system. It describes the importance of the presence and effects of magnesium on various key processes and functions occurring in the body. The reasons for the lack of magnesium and ways to replenish it both in the natural way (eating, certain foods) and magnesium preparations are considered. The article provides examples of large randomized studies that prove the importance of the influence of normal magnesium levels on human health in general and on the state of the cardiovascular system. These studies show how magnesium deficiency increases the risk of cardiovascular diseases and how it can be reduced. It is also shown which trace elements and vitamins are closely related to magnesium metabolism, and how they (in particular, potassium and vitamin B6) improve and facilitate the normalization of magnesium levels. It is noted how comorbidity decreases with the normalization of magnesium level – the higher the magnesium level in the blood plasma (closer to the upper limit and more), the less comorbidity and longer life expectancy. Magnesium is an absolutely essential ion and a good medicine. Magnesium deficiency and hypomagnesemia are quite common, difficult to diagnose (due to underestimation and rare level control) and accompany many diseases of the cardiovascular system and beyond. The widespread use of organic magnesium salts would improve the situation as a whole, due to their universal multiple effect on many processes in the body. This is an integral part of therapeutic and preventive measures in patients with already existing diseases and in people who do not have diseases, but who are at risk due to existing hypomagnesemia.</p></abstract><trans-abstract xml:lang="ru"><p>Статья посвящена влиянию магния на гомеостаз организма и, в частности, на сердечно-сосудистую систему. В ней описывается важность присутствия и воздействия магния на различные ключевые процессы и функции, происходящие в организме. Отмечаются причины нехватки магния и пути восполнения его как естественным путем (прием пищи, определенных продуктов питания), так и препаратами магния. В статье приведены примеры больших рандомизированных исследований, доказывающих важность влияния нормальных уровней магния на здоровье человека в целом и на состояние сердечно-сосудистой системы. Эти исследования показывают, насколько нехватка магния повышает риск заболеваний сердечно-сосудистой системы, и как можно его уменьшить. Так же показано, какие микроэлементы и витамины тесно связаны с магниевым обменом и насколько улучшается и облегчается нормализация уровня магния в присутствии этих микроэлементов и витаминов (в частности, калия и витамина В6). Отмечается, как уменьшается коморбидность при нормализации уровня магния – чем выше уровень магния в плазме крови (ближе к верхней границе и больше), тем меньше коморбидность и больше продолжительность жизни. Магний является абсолютно необходимым ионом и хорошим лекарством. Дефицит магния и гипомагниемия встречаются часто, трудно диагностируются (в связи с недооценкой и редким контролем уровня) и сопровождают многие заболевания сердечно-сосудистой системы, и не только. Широкое применение органических солей магния улучшило бы ситуацию в целом в связи с их универсальным множественным влиянием на многие процессы в организме. Это составляет неотъемлемую часть терапевтических и профилактических мероприятий как у пациентов с уже возникшей патологией, так и у людей, не имеющих заболеваний, но входящих в группу риска в связи с имеющейся гипомагниемией.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечно-сосудистая патология</kwd><kwd>магний</kwd><kwd>калий</kwd><kwd>витамин В6</kwd><kwd>артериальная гипертония</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>нарушения ритма сердца</kwd><kwd>органические соли магния</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiovascular diseases</kwd><kwd>magnesium</kwd><kwd>potassium</kwd><kwd>vitamin B6</kwd><kwd>arterial hypertension</kwd><kwd>ischemic heart disease</kwd><kwd>heart rhythm disorders</kwd><kwd>organic salts of magnesium</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Кудрин А.В., Громова О.А. Микроэлементы в неврологии. 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