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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2019-15-6-813-819</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-2073</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>NOTES FROM PRACTICE</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>КЛИНИЧЕСКИЙ ОПЫТ</subject></subj-group></article-categories><title-group><article-title>Quantitative Assessment of Myocardial Ischemia in Multi-Vessel Coronary Artery Disease by Multimodal Stress Echocardiography with Semi-Supine Bicycle Ergometry</article-title><trans-title-group xml:lang="ru"><trans-title>Количественная оценка ишемии миокарда при многососудистом поражении коронарных артерий с помощью мультимодальной стресс-эхокардиографии с полугоризонтальной велоэргометрией</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Корецкий</surname><given-names>С. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Koretskiy</surname><given-names>S. N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Корецкий Сергей Николаевич – кандидат медицинских наук, ведущий научный сотрудник, отдел фундаментальных и прикладных аспектов ожирения; врач функциональной диагностики, отделение функциональной диагностики</p><p>101990, Москва, Петроверигский пер., 10 </p></bio><bio xml:lang="en"><p>Sergey N. Koretskiy – MD, PhD, Leading Researcher, Department of Fundamental and Applied Aspects of Obesity; Physician, Functional Diagnostic Department</p><p>Petroverigsky per. 10, Moscow, 101990 </p></bio><email xlink:type="simple">snkoretskiy@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Драпкина</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Drapkina</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Драпкина Оксана Михайловна – доктор медицинских наук, профессор, член корреспондент РАН, директор</p><p>101990, Москва, Петроверигский пер., 10 </p></bio><bio xml:lang="en"><p>Oxana M. Drapkina – MD, PhD, Professor, Corresponding Member of the Russian Academy of Sciences, Director</p><p>Petroverigsky per. 10, Moscow, 101990 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шукуров</surname><given-names>Ф. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Shukurov</surname><given-names>F. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шукуров Фирдавс Баходурович – эндоваскулярный хирург, отделение рентгенхирургических методов диагностики и лечения</p><p>101990, Москва, Петроверигский пер., 10 </p></bio><bio xml:lang="en"><p>Firdavs B. Shukurov – MD, Endovascular Surgeon, Department of Roentgen-Endovascular Diagnostics and Treatment (Interventional Cardiology)</p><p>Petroverigsky per. 10, Moscow, 101990 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Васильев</surname><given-names>Д. К.</given-names></name><name name-style="western" xml:lang="en"><surname>Vasiliev</surname><given-names>D. K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Васильев Дмитрий Константинович – младший научный сотрудник, отдел инновационных эндоваскулярных методов профилактики и лечения сердечно-сосудистых заболеваний</p><p>101990, Москва, Петроверигский пер., 10 </p></bio><bio xml:lang="en"><p>Dmitriy K. Vasiliev – MD, Researcher, Department of Innovative Endovascular Methods for the Prevention and Treatment of Cardiovascular Diseases</p><p>Petroverigsky per. 10, Moscow, 101990 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр профилактической медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Preventive Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2019</year></pub-date><pub-date pub-type="epub"><day>02</day><month>01</month><year>2020</year></pub-date><volume>15</volume><issue>6</issue><fpage>813</fpage><lpage>819</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Koretskiy S.N., Drapkina O.M., Shukurov F.B., Vasiliev D.K., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Корецкий С.Н., Драпкина О.М., Шукуров Ф.Б., Васильев Д.К.</copyright-holder><copyright-holder xml:lang="en">Koretskiy S.N., Drapkina O.M., Shukurov F.B., Vasiliev D.K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/2073">https://www.rpcardio.online/jour/article/view/2073</self-uri><abstract><p>Stress echocardiography is a modern widely used method of noninvasive diagnosis of coronary heart disease and stratification of the risk of cardiovascular complications. In addition, exercise echocardiography is an important tool to clarify the localization of ischemia and establish a symptomassociated artery for management of patient with known coronary angiography data. This is especially important in multivessel lesions, the presence of an occluded artery or borderline stenosis. Currently, various stress agents are used for stress echocardiography in clinical practice: pharmacological drugs (dobutamine or adenosine), transesophageal or endocardial pacing, treadmill, semi-supine bicycle. To detect signs of ischemia usually used only visual estimation of local contractility in the two-dimensional gray-scale mode. Modern modes of myocardial imaging, such as speckletracking echocardiography or three-dimensional visualization, are practically not used. In the presented clinical case, the possibility of combining standard and modern imaging modes to clarify the localization and quantification of ischemia in multivessel coronary lesions, including chronic artery occlusion, is shown. As a stress agent, a semi-supine bicycle was chosen, the use of which allowed to obtain a qualitative image of the left ventricular myocardium at rest and at peak load, suitable for assessing deformation and threedimensional visualization. Evaluation of left ventricular myocardial deformation by speckle-tracking echocardiography was more accurate than standard diagnosis in detecting signs of ischemia in a patient with multivessel lesions. Three-dimensional imaging was inferior in sensitivity to speckletracking stress echocardiography and, at present, seems to have more research value.</p></abstract><trans-abstract xml:lang="ru"><p>Стресс-эхокардиография – современный широко используемый метод неинвазивной диагностики ишемической болезни сердца и стратификации риска сердечно-сосудистых осложнений. Нагрузочная эхокардиография применяется также для уточнения локализации ишемии и установления симптом-связанной артерии при известных данных коронарной ангиографии для определения дальнейшей тактики. Это особенно важно при многососудистом поражении, наличии окклюзированной артерии или пограничного стеноза. В настоящее время в клинической практике для проведения стресс-эхокардиографии используются различные стресс-агенты: фармакологические препараты (добутамин или аденозин), чреспищеводная или эндокардиальная стимуляция, тредмил, «лежачий» велоэргометр. Для выявления признаков ишемии обычно применяется только визуальная оценка локальной сократимости в двухмерном серошкальном режиме. Современные режимы визуализации миокарда, такие как отслеживание пятнистых структур или трехмерная визуализация практически не применяются. В представленном клиническом случае показана возможность сочетания стандартных и современных режимов визуализации для уточнения локализации и количественной оценки ишемии при многососудистом поражении коронарного русла, включающее хроническую окклюзию артерии. В качестве стресс-агента был выбран «лежачий» велоэргометр, применение которого позволило получить пригодное для оценки деформации и трехмерной визуализации качественное изображение миокарда левого желудочка в покое и на пике нагрузки. Оценка деформации миокарда левого желудочка с помощью технологии отслеживания пятнистых структур была более точной по сравнению со стандартной диагностикой при выявлении признаков ишемии у пациента с многососудистым поражением. Трехмерная визуализация уступала в чувствительности стресс-эхокардиографии с отслеживанием пятнистых структур, и в настоящее время, видимо, имеет больше исследовательское значение.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мультимодальная стресс-эхокардиография</kwd><kwd>«лежачий» велоэргометр</kwd><kwd>отслеживание пятнистых структур</kwd><kwd>трехмерная визуализация</kwd><kwd>ишемическая болезнь сердца</kwd><kwd>многососудистое поражение коронарных артерий</kwd></kwd-group><kwd-group xml:lang="en"><kwd>multimodal stress echocardiography</kwd><kwd>semi-supine bicycle</kwd><kwd>speckle tracking</kwd><kwd>three-dimensional visualization</kwd><kwd>coronary heart disease</kwd><kwd>multivessel coronary heart disease</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">National Heart, Lung, and Blood Institute. 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