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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2020-06-15</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-2216</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group></article-categories><title-group><article-title>Possibilities of Pulse Wave Contour Analysis in Diagnostics of Early Vascular Aging</article-title><trans-title-group xml:lang="ru"><trans-title>Возможности контурного анализа пульсовой волны в диагностике раннего сосудистого старения</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Туктаров</surname><given-names>А. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Tuktarov</surname><given-names>A. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Туктаров Артур Марсович - ординатор, кафедра госпитальной терапии, медицинский факультет, СПбГУ; врач-терапевт, Международный медицинский центр «СОГАЗ».</p><p>199034, Санкт-Петербург, Университетская наб., 7/9; 191186, Санкт-Петербург, ул. Малая Конюшенная, 8.</p></bio><bio xml:lang="en"><p>Arthur M. Tuktarov - MD, Resident, Chair of Hospital Therapy, Faculty of Medicine, Saint Petersburg State University; Therapist, International Medical Center “SOGAZ”.</p><p>Universitetskaya nab. 7/9, Saint Petersburg, 199034; Malaya Konyushennaya ul. 8, Saint Petersburg, 191186.</p></bio><email xlink:type="simple">artur-tuktarov@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филиппов</surname><given-names>А. Е.</given-names></name><name name-style="western" xml:lang="en"><surname>Filippov</surname><given-names>A. E.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Филиппов Александр Евгеньевич - доктор медицинских наук, профессор, кафедра госпитальной терапии, медицинский факультет, СПбГУ; руководитель центра атеросклероза и нарушений липидного обмена, Международный медицинский центр «СОГАЗ».</p><p>199034, Санкт-Петербург, Университетская наб., 7/9; 191186, Санкт-Петербург, ул. Малая Конюшенная, 8.</p></bio><bio xml:lang="en"><p>Alexander E. Filippov - MD, PhD, Professor, Chair of Hospital Therapy, Faculty of Medicine, Saint Petersburg State University; Head of Center for Atherosclerosis and Lipid Metabolism Disorders, International Medical Center “SOGAZ”.</p><p>Universitetskaya nab. 7/9, Saint Petersburg, 199034; Malaya Konyushennaya ul. 8, Saint Petersburg, 191186.</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Обрезан</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Obrezan</surname><given-names>A. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Обрезан Андрей Андреевич - ординатор, кафедра госпитальной терапии, медицинский факультет, СПбГУ.</p><p>199034, Санкт-Петербург, Университетская наб., 7/9.</p></bio><bio xml:lang="en"><p>Andrey A. Obrezan - Resident, Chair of Hospital Therapy, Faculty of Medicine, Saint Petersburg State University.</p><p>Universitetskaya nab. 7/9, Saint Petersburg, 199034.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куколь</surname><given-names>Л. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kukol'</surname><given-names>L. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Куколь Лидия Владимировна - доктор медицинских наук, профессор, кафедра госпитальной терапии, медицинский факультет, СПбГУ.</p><p>199034, Санкт-Петербург, Университетская наб., 7/9.</p></bio><bio xml:lang="en"><p>Lidia V. Kukol' - MD, PhD, Professor, Chair of Hospital Therapy, Faculty of Medicine, Saint Petersburg State University.</p><p>Universitetskaya nab. 7/9, Saint Petersburg, 199034.</p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Санкт-Петербургский государственный университет; ООО Международный медицинский центр «СОГАЗ»</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg State University; LLC International Medical Center “SOGAZ”.</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Санкт-Петербургский государственный университет</institution><country>Россия</country></aff><aff xml:lang="en"><institution>St. Petersburg State University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>03</day><month>07</month><year>2020</year></pub-date><volume>16</volume><issue>3</issue><fpage>356</fpage><lpage>362</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Tuktarov A.M., Filippov A.E., Obrezan A.A., Kukol' L.V., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Туктаров А.М., Филиппов А.Е., Обрезан А.А., Куколь Л.В.</copyright-holder><copyright-holder xml:lang="en">Tuktarov A.M., Filippov A.E., Obrezan A.A., Kukol' L.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/2216">https://www.rpcardio.online/jour/article/view/2216</self-uri><abstract><sec><title>Aim</title><p>Aim. To study the possibilities of photoplethysmography (PPG) in evaluation of arterial stiffness, arterial age and early vascular aging (EVA) in healthy individuals and patients with cardiovascular risk factors.</p></sec><sec><title>Material and methods</title><p>Material and methods. The material of the study was the data from a survey of large teams undergoing medical examination in a group of clinics of Medical Center “SOGAZ”. A total of 783 men aged from 20 to 92 years were examined. The mean age was 48.2±10.32 years. PPG was used as a special research method, performed using the AngioScan-01 diagnostic complex. The following indicators were evaluated: stiffness index (SI), reflection index (RI), augmentation index (Alp75), age index (AGI) and pulse wave types (PV-type). For determining the vascular age (VA), correlation field of the dependence of AGI on the age of the subject was built, and then the VA was calculated by the value of the AGI.</p></sec><sec><title>Results</title><p>Results. The greatest correlation with passport age was revealed for the AGI indicator (r=0.54) at the first stage of the study. EVA-syndrome criteria were considered as values of the AGI, beyond the 90th percentile (n=65), and the criteria for “young vascular age” (n=87) were AGI values below 10 percentile with age correction. Comparison of these two alternative subgroups (in men aged from 40 to 59) in terms of arterial stiffness showed significant differences in SI (8.2±0.99 vs 7.6±0.89, respectively, p=0.001), Alp75 (-0.2±14.54 vs 20.5±10.31, respectively, p=0.0001), PV-type. The frequency of detection of multiple risk factors according to the results of questionnaires and laboratory diagnostics in patients with EVA-syndrome was also significantly higher. Assessment of the contribution of vascular risk factors to vascular aging showed that the leading positions are occupied by hypertension, hypertriglyceridemia, abdominal obesity, hyperglycemia, and smoking.</p></sec><sec><title>Conclusion</title><p>Conclusion. PPG is a simple, fast, and informative method that allows to evaluate the parameters of the vascular wall stiffness. It can be assumed that its use in screening examinations of middle-aged men can help in identifying patients requiring observation and intensive prevention.</p></sec></abstract><trans-abstract xml:lang="ru"><sec><title>Цель</title><p>Цель. Изучить возможности фотоплетизмографии (ФПГ) в оценке артериальной жесткости, артериального возраста и раннего сосудистого старения у здоровых и больных лиц с факторами риска сердечно-сосудистых заболеваний.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. Материалом исследования послужили данные обследования крупных коллективов, проходивших диспансеризацию в группе клиник медицинского центра «СОГАЗ». Всего обследовано 783 мужчин в возрасте от 20 до 92 лет. Средний возраст составил 48,2±10,32 лет. В качестве специального метода исследования использовалась ФПГ, проводимая с помощью диагностического комплекса «АнгиоСкан-01». Оценивались показатели: индекс жесткости (SI), индекс отражения (RI), индекс аугментации (Alp75), возрастной индекс (AGI) и типы пульсовой волны (PV-type). Для определения сосудистого возраста (VA) строилось корреляционное поле зависимости AGI от возраста испытуемого, и затем по величине AGI рассчитывался VA.</p></sec><sec><title>Результаты</title><p>Результаты. При анализе взаимосвязи показателей ФПГ наиболее сильная связь с паспортным возрастом была выявлена для показателя AGI (r=0,54). Критериями раннего сосудистого старения (EVA-синдрома) считались значения AGI, выходящие за пределы 90-го перцентиля (n=65), критериями «молодого сосудистого возраста» (n=87) - значения AGI менее 1 0 перцентиля с коррекцией по возрасту. Сравнение этих двух альтернативных подгрупп (мужчин в возрасте от 40 до 59 лет) по параметрам артериальной жесткости показало значимые различия по показателям SI (8,2±0,99 против 7,6±0,89, соответственно; p=0,001), Alp75 (-0,2±14,54 против 20,5±10,31, соответственно; p=0,0001), PV-type. Частота выявления множественных факторов риска по результатам анкетирования и лабораторной диагностики у пациентов с EVA-синдромом была также значимо больше. Оценка вклада сосудистых факторов риска в сосудистое старение показала, что лидирующие позиции занимают артериальная гипертензия, гипертриглицеридемия, абдоминальное ожирение, гипергликемия и курение. </p></sec><sec><title>Заключение</title><p>Заключение. ФПГ является простым, быстрым и информативным методом, позволяющим оценить параметры жесткости сосудистой стенки. Можно полагать, что ее использование в скрининговых обследованиях мужчин среднего возраста может помочь в выявлении пациентов, требующих наблюдения и интенсивной профилактики.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная ригидность</kwd><kwd>сосудистый возраст</kwd><kwd>фотоплетизмография</kwd><kwd>раннее сосудистое старение</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial stiffness</kwd><kwd>vascular age</kwd><kwd>photoplethysmography</kwd><kwd>early vascular aging</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Townsend N., Wilson L., Bhatnagar P., et al. Cardiovascular disease in Europe: Epidemiological update 2016. Eur Heart J. 2016;37(42):3232-45. 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