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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2014-10-5-554-558</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-222</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group></article-categories><title-group><article-title>EVOLUTION OF THROMBOLYTIC THERAPY IN THE TREATMENT OF MYOCARDIAL INFARCTION</article-title><trans-title-group xml:lang="ru"><trans-title>ЭВОЛЮЦИЯ ТРОМБОЛИТИЧЕСКОЙ ТЕРАПИИ В ЛЕЧЕНИИ ИНФАРКТА МИОКАРДА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кесов</surname><given-names>П. Г.</given-names></name><name name-style="western" xml:lang="en"><surname>Kesov</surname><given-names>P. G.</given-names></name></name-alternatives><bio xml:lang="ru"><p>врач-кардиолог</p><p>625023, Тюмень, ул. Одесская, 46А</p></bio><bio xml:lang="en"><p>Odesskaya ul. 46A, Tyumen, 625023 Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Рейтблат</surname><given-names>О. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Reytblat</surname><given-names>O. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., зав. кардиологическим отделением</p><p>625023, Тюмень, ул. Одесская, 46А</p></bio><bio xml:lang="en"><p>Odesskaya ul. 46A, Tyumen, 625023 Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сафиуллина</surname><given-names>З. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Safiullina</surname><given-names>Z. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор кафедры кардиологии</p></bio><bio xml:lang="en"><p>Odesskaya ul. 46A, Tyumen, 625023 Russia</p></bio><email xlink:type="simple">safiullina@tokb.ru</email><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шалаев</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Shalaev</surname><given-names>S. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, зав. той же кафедрой; руководитель</p><p>625023, Тюмень, ул. Одесская, 46А</p><p>625023, Тюмень, ул. Одесская, 54</p></bio><bio xml:lang="en"><p>Odesskaya ul. 46A, Tyumen, 625023 Russia</p><p>Odesskaya ul. 46A, Tyumen, 625023 Russia</p></bio><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Областной кардиологический диспансер Областной клинической больницы №1</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Cardiology Clinic of Tyumen Regional Hospital №1</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Тюменская государственная медицинская академия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Tyumen State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-3"><aff xml:lang="ru"><institution>Областной кардиологический диспансер Областной клинической больницы №1, Тюменская государственная медицинская академия</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Regional Cardiology Clinic of Tyumen Regional Hospital №1, Tyumen State Medical Academy</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>24</day><month>09</month><year>2015</year></pub-date><volume>10</volume><issue>5</issue><fpage>554</fpage><lpage>558</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Kesov P.G., Reytblat O.M., Safiullina Z.M., Shalaev S.V., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Кесов П.Г., Рейтблат О.М., Сафиуллина З.М., Шалаев С.В.</copyright-holder><copyright-holder xml:lang="en">Kesov P.G., Reytblat O.M., Safiullina Z.M., Shalaev S.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/222">https://www.rpcardio.online/jour/article/view/222</self-uri><abstract><p>History of thrombolytic therapy is shortly reflected, main trials of various thrombolytics in acute ST-segment elevation myocardial infarction (STEMI) are analyzed. Perspectives of modern thrombolytic therapy in patients with STEMI are discussed.</p></abstract><trans-abstract xml:lang="ru"><p>Отражается краткая история тромболитической терапии (ТЛТ), рассматриваются основные исследования по применению различных тромболитических препаратов в лечении инфаркта миокарда (ИМ) с подъёмом сегмента ST. Освещаются позиции ТЛТ в современном лечении ИМ.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>тромболитическая терапия</kwd><kwd>инфаркт миокарда с подъёмом сегмента ST</kwd></kwd-group><kwd-group xml:lang="en"><kwd>thrombolytic therapy</kwd><kwd>ACS with ST-segment elevation</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chazov E.I., Ruda M.J. Development of the main directions in the treatment of patients with myocardial infarction in the last 25 years. Cardiology 1989; (11): 11-5. Russian (Чазов Е.И., Руда М.Я. 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