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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2014-10-5-559-564</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-223</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CURRENT QUESTIONS OF CLINICAL PHARMACOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ  ВОПРОСЫ  КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>USE OF URAPIDIL - ANTIHYPERTENSIVE DRUG WITH DOUBLE ACTION - NEW DIRECTION IN TREATMENT OF HYPERTENSIVE CRISES</article-title><trans-title-group xml:lang="ru"><trans-title>ПРИМЕНЕНИЕ УРАПИДИЛА – АНТИГИПЕРТЕНЗИВНОГО ПРЕПАРАТА С ДВОЙНЫМ МЕХАНИЗМОМ ДЕЙСТВИЯ – НОВОЕ НАПРАВЛЕНИЕ В ЛЕЧЕНИИ ГИПЕРТОНИЧЕСКИХ КРИЗОВ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Абдрахманов</surname><given-names>В. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Abdrakhmanov</surname><given-names>V. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор кафедры скорой медицинской помощи</p><p>127473, Москва, ул. Делегатская, 20/1</p></bio><bio xml:lang="en"><p>Delegatskaya ul. 20/1, Moscow, 127473 Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гапонова</surname><given-names>Н. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Gaponova</surname><given-names>N. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор той же кафедры</p><p>127473, Москва, ул. Делегатская, 20/1</p></bio><bio xml:lang="en"><p>Delegatskaya ul. 20/1, Moscow, 127473 Russia</p></bio><email xlink:type="simple">nade-gaponova@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Плавунов</surname><given-names>Н. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Plavunov</surname><given-names>N. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, заведующий той же кафедрой</p><p>127473, Москва, ул. Делегатская, 20/1</p></bio><bio xml:lang="en"><p>Delegatskaya ul. 20/1, Moscow, 127473 Russia</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Московский государственный медико-стоматологический университет им. А.И. Евдокимова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Moscow State University of Medicine and Dentistry named after A.I. Evdokimov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2014</year></pub-date><pub-date pub-type="epub"><day>24</day><month>09</month><year>2015</year></pub-date><volume>10</volume><issue>5</issue><fpage>559</fpage><lpage>564</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Abdrakhmanov V.R., Gaponova N.I., Plavunov N.F., 2015</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="ru">Абдрахманов В.Р., Гапонова Н.И., Плавунов Н.Ф.</copyright-holder><copyright-holder xml:lang="en">Abdrakhmanov V.R., Gaponova N.I., Plavunov N.F.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/223">https://www.rpcardio.online/jour/article/view/223</self-uri><abstract><p>Results of clinical trials devoted to urapidil, antihypertensive drug having central and peripheral mode of actions are reviewed. Target groups of patients for urapidil use are specified. Dosage regimen and methods of urapidil use in different clinical situations with acute increase in arterial blood pressure are described in details.</p></abstract><trans-abstract xml:lang="ru"><p>Обсуждаются результаты клинических исследований, посвященных антигипертензивному действию препарата урапидил, обладающего центральным и периферическим действием. Выделены группы пациентов, которым показано применение урапидила. Подробно изложен режим дозирования и способы применения урапидила при различных клинических ситуациях, сопровождающихся острым повышением артериального давления.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>артериальная гипертензия</kwd><kwd>гипертонический криз</kwd><kwd>антигипертензивная терапия</kwd><kwd>урапидил</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial hypertension</kwd><kwd>hypertensive crisis</kwd><kwd>antihypertensive therapy</kwd><kwd>urapidil</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Giilis R.A., Kellar K.J., Quest J.A., et al. Experimental studies on the neurocardiovascular effects of urapidil. Drugs 1988; 35: 20-33.</mixed-citation><mixed-citation xml:lang="en">Giilis R.A., Kellar K.J., Quest J.A., et al. Experimental studies on the neurocardiovascular effects of urapidil. 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