rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2020-06-08rpcardio-2230Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИDrug Interactions and Side Effects of Co-Administration of Chloroquine/Hydroxychloroquine and Azithromycin: on the Issue of Rational Pharmacotherapy of Patients with COVID-19 with Antimalarial DrugsЛекарственные взаимодействия и побочные эффекты совместного назначения хлорохина/гидроксихлорохина и азитромицина: к вопросу рациональной фармакотерапии пациентов с COVID-19 противомалярийными препаратамиГайсенокО. В.GaisenokO. V.

Гайсенок Олег Владимирович - кандидат медицинских наук, заведующий терапевтическим отделением, Объединенная больница с поликлиникой Управления делами Президента РФ.

119285, Москва, Мичуринский пр-т, 6.

Oleg V. Gaisenok - MD, PhD, Head of Therapeutic Department, United Hospital with Outpatient Department, Administrative Department of the President of the Russian Federation.

Michurinskypr. 6, Moscow, 119285.

ovgaisenok@fgu-obp.ruОбъединенная больница с поликлиникой Управления делами Президента РФРоссияUnited Hospital with Outpatient Department, Administrative Department of the President of the Russian FederationRussian Federation202004072020163481486Copyright © Gaisenok O.V., 20202020Гайсенок О.В.Gaisenok O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/2230

This review analyzes existing approaches to the treatment of COVID-19 patients with antimalarial drugs from the standpoint of rational pharmacotherapy. Particular attention is paid to drug interactions and side effects of co-administration of chloroquine/hydroxychloroquine and azithromycin, considering the problem of cardiotoxicity and the high likelihood of cardiovascular disease in middle-aged and elderly people with COVID-19. The article discusses the prospects of using another representative from the group of antimalarial drugs - mefloquine in the treatment of COVID-19. Special attention is paid to the “proarrhythmogenic” side effects of azithromycin therapy, as well as to the problem of resistance of microorganisms to macrolides during antibiotic therapy of pneumonia, in particular to azithromycin. In conclusion, the article discusses the possibilities of alternative methods in the treatment of this disease.

С позиций рациональной фармакотерапии проведен анализ существующих подходов к лечению пациентов с COVID-19 противомалярийными препаратами. Особое внимание уделено лекарственным взаимодействиям и побочным эффектам совместного назначения хлорохина/гид-роксихлорохина и азитромицина, с учетом проблемы кардиотоксичности и большой вероятности наличия сердечно-сосудистых заболеваний у лиц среднего и пожилого возраста с COVID-19. Рассматриваются перспективы применения еще одного представителя из группы противомалярийных препаратов - мефлохина в лечении COVID-1 9. Отдельное внимание уделено «проаритмогенным» побочным эффектам терапии азитромицином, а также проблеме резистентности микроорганизмов к макролидам при антибиотикотерапии пневмоний, в частности, к азитромицину. В заключении статьи рассматриваются возможности альтернативных методов лечения данного заболевания.

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The authors declare that there are no conflicts of interest present.