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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2020-2020-08-17</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-2250</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group></article-categories><title-group><article-title>Features of Structural and Functional Changes in the Heart in Elderly Patients with Coronary Heart Disease and Atrial Fibrillation</article-title><trans-title-group xml:lang="ru"><trans-title>Структурные и функциональные изменения миокарда у больных пожилого возраста с ишемической болезнью сердца и фибрилляцией предсердий</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фоломеева</surname><given-names>Л. И.</given-names></name><name name-style="western" xml:lang="en"><surname>Folomeeva</surname><given-names>L. I.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фоломеева Лариса Игоревна – врач-кардиолог</p><p>119415, Москва, ул. Лобачевского, 42 </p></bio><bio xml:lang="en"><p>Larisa I. Folomeeva – MD, Cardiologist</p><p>Lobachevskogo ul. 42, Moscow, 119415 </p></bio><email xlink:type="simple">larisaigorevna.kudryavtseva@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Филиппов</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Filippov</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Филиппов Евгений Владимирович – доктор медицинских наук, доцент, кафедра поликлинической терапии и профилактической медицины</p><p>390026, Рязань, Высоковольтная ул., 9 </p></bio><bio xml:lang="en"><p>Eugene V. Filippov – MD, PhD, Associate Professor, Chair of Outpatient Therapy and Preventive Medicine</p><p>Vysokovoltnaya ul. 9, Ryazan, 390026 </p></bio><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Городская клиническая больница №31 (Москва)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>City Clinical Hospital №31 (Moscow)</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Рязанский государственный медицинский университет им. академика И.П. Павлова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Ryazan State Medical University named after Academician I.P. Pavlov</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>31</day><month>08</month><year>2020</year></pub-date><volume>16</volume><issue>4</issue><fpage>536</fpage><lpage>541</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Folomeeva L.I., Filippov E.V., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Фоломеева Л.И., Филиппов Е.В.</copyright-holder><copyright-holder xml:lang="en">Folomeeva L.I., Filippov E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/2250">https://www.rpcardio.online/jour/article/view/2250</self-uri><abstract><p>Supraventricular arrhythmias, including atrial fibrillation (AF), are a current problem for patients in the older age group due to the possibility of lifethreatening complications. Elderly patients have pre-conditions for the development of supraventricular rhythm disturbances (age-related structural and functional changes in the myocardium, concomitant diseases).</p><sec><title>Aim</title><p>Aim. To study the features of structural and functional changes in the myocardium of the left heart in elderly patients, depending on the presence of supraventricular arrhythmias.</p></sec><sec><title>Material and methods</title><p>Material and methods. The cross-sectional study included 200 individuals aged 60 to 89 years. All participants underwent echocardiographic examination and 24-hour electrocardiogram (ECG) monitoring. The patients of the study cohort were divided into 3 groups: group 1 consisted of patients with coronary heart disease (CHD) without heart rhythm disturbances (n=80); group 2 consisted of patients with CHD and paroxysmal AF (n=40); group 3 consisted of patients with CHD and supraventricular extrasystoles (n=40). The control group consisted of patients of the older age group without CHD and rhythm disturbances (n=40).</p></sec><sec><title>Results</title><p>Results. In patients with paroxysmal AF and frequent supraventricular extrasystoles, large sizes of the left atrium were revealed (anteroposterior dimension: 4.30±0.07 and 4.12±0.12 cm; upper-lower: 6.15±0.03 and 5.96±0.10 cm; medial-lateral: 4.15±0.11 and 3.87±0.09 cm, respectively). In patients with CHD and rhythm disturbances, the presence of a combined increase in the size of the left atrium and a decrease in myocardial contractility was revealed (ejection fraction of the left atrium in groups 2 and 3 – 27.2±0.1% and 27.9±0.1%, respectively, vs 36.3±0.1% and 38.20±0.02%, respectively in group 1 and control). The duration of ischemic changes during 24-hour ECG monitoring was also greater in group 3 compared with groups 1 and 2 (249.6 vs 27.1 and 66.4 min, respectively). In groups 2 and 3, a discordant effect of the sympathetic and parasympathetic nervous systems on heart rate variability was revealed.</p></sec><sec><title>Conclusion</title><p>Conclusion. For elderly patients, morphological and functional changes are characteristic, which consist in the restructuring of the myocardium and changes in heart rate variability with a prevalence of the sympathetic part of the autonomic nervous system.</p></sec></abstract><trans-abstract xml:lang="ru"><p>Суправентрикулярные аритмии, в том числе, фибрилляция предсердий (ФП) являются актуальной проблемой для пациентов старшей возрастной группы из-за возможности развития жизнеугрожающих осложнений. Пациенты пожилого возраста имеют предпосылки к появлению суправентрикулярных нарушений ритма (возрастные структурно-функциональные изменения миокарда, сопутствующие заболевания).</p><sec><title>Цель</title><p>Цель. Изучить особенности структурно-функциональных изменений миокарда левых отделов сердца у пациентов пожилого возраста в зависимости от наличия суправентрикулярных аритмий.</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В поперечное исследование включены 200 лиц в возрасте от 60 до 89 лет. Всем участникам выполняли эхокардиографическое исследование и суточное мониторирование электрокардиограммы (ЭКГ). Пациенты исследуемой когорты были разделены на 3 группы: 1 группу составили больные с ишемической болезнью сердца (ИБС) без нарушения ритма сердца (n=80); 2 группу составили больные с ИБС и пароксизмальной формой ФП (n=40); 3 группу составили больные с ИБС и суправентрикулярной экстрасистолией (n=40). Группу контроля составили пациенты без ИБС и нарушений ритма старшей возрастной группы (n=40).</p></sec><sec><title>Результаты</title><p>Результаты. У больных с пароксизмальной ФП и частой суправентрикулярной экстрасистолией были выявлены бо̀льшие размеры левого предсердия (переднезадний размер: 4,30±0,07 и 4,12±0,12 см; верхне-нижний: 6,15±0,03 и 5,96±0,10 см; медиально-латеральный: 4,15±0,11 и 3,87±0,09 см, соответственно). У пациентов, страдающих ИБС и нарушением ритма, выявлено наличие сочетанного увеличения размеров левого предсердия и снижения сократительной способности миокарда (фракция выброса левого предсердия в 2 и 3 группах – 27,2±0,1% и 27,9±0,1%, соответственно, против 36,3±0,1% и 38,20±0,02%, соответственно, в группе 1 и в контроле). Длительность ишемических изменений при суточном мониторировании ЭКГ также была больше в 3 группе по сравнению с 1 и 2 группами (249,6 против 27,1 и 66,4 мин, соответственно). В группах 2 и 3 выявлено дискордантное влияние симпатической и парасимпатической нервной системы на вариабельность ритма сердца.</p></sec><sec><title>Заключение</title><p>Заключение. Для пациентов пожилого возраста являются характерными морфофункциональные изменения, которые заключаются в структурной перестройке миокарда и изменении вариабельности сердечного ритма с превалированием симпатического отдела вегетативной нервной системы.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>ишемическая болезнь сердца</kwd><kwd>фибрилляция предсердий</kwd><kwd>левое предсердие</kwd><kwd>суправентрикулярные аритмии</kwd><kwd>левый желудочек</kwd></kwd-group><kwd-group xml:lang="en"><kwd>coronary heart disease</kwd><kwd>atrial fibrillation</kwd><kwd>left atrium</kwd><kwd>supraventricular arrhythmias</kwd><kwd>left ventricle</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Chugh S.S., Havmoeller R., Narayanan K., et al. Worldwide epidemiology of atrial fibrillation: a Global Burden of Disease 2010 Study. Circulation. 2014;129(8):837-47. 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