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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2020-08-02</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-2261</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>POINT OF VIEW</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ТОЧКА ЗРЕНИЯ</subject></subj-group></article-categories><title-group><article-title>The Peculiarity of Process and Treatment of Arterial Hypertension in Patients with Type 2 Diabetes Mellitus</article-title><trans-title-group xml:lang="ru"><trans-title>Особенности течения и лечение артериальной гипертензии у пациентов с сахарным диабетом 2 типа</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Демидова</surname><given-names>Т. Ю.</given-names></name><name name-style="western" xml:lang="en"><surname>Demidova</surname><given-names>T. Yu.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Демидова Татьяна Юльевна – доктор медицинских наук, профессор, заведующая кафедрой эндокринологии</p><p>117997, Москва, ул. Островитянова, 1 </p></bio><bio xml:lang="en"><p>Tatyana Yu. Demidova – MD, PhD, Professor, Head of Chair of Endocrinology</p><p>Ostrovitianova ul. 1, Moscow, 117997 </p></bio><email xlink:type="simple">t.y.demidova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кисляк</surname><given-names>О. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kislyak</surname><given-names>O. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кисляк Оксана Андреевна – доктор медицинских наук, профессор, заведующая кафедрой факультетской терапии</p><p>117997, Москва, ул. Островитянова, 1 </p></bio><bio xml:lang="en"><p>Oksana A. Kislyak – MD, PhD, Professor, Head of Chair of Faculty Therapy</p><p>Ostrovitianova ul. 1, Moscow, 117997 </p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Российский национальный исследовательский медицинский университет им. Н.И. Пирогова</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Pirogov Russian National Research Medical University</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2020</year></pub-date><pub-date pub-type="epub"><day>02</day><month>09</month><year>2020</year></pub-date><volume>16</volume><issue>4</issue><fpage>623</fpage><lpage>634</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Demidova T.Y., Kislyak O.A., 2020</copyright-statement><copyright-year>2020</copyright-year><copyright-holder xml:lang="ru">Демидова Т.Ю., Кисляк О.А.</copyright-holder><copyright-holder xml:lang="en">Demidova T.Y., Kislyak O.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/2261">https://www.rpcardio.online/jour/article/view/2261</self-uri><abstract><p>Arterial hypertension (AH) is powerful and modifying factor of developing macrovascular and microvascular complications of diabetes. Patients with AH and diabetes belong to group with high and very high levels risk of developing cardiovascular complications and chronic kidney disease. The combination of type 2 diabetes mellitus and AH dramatically increases the risk of developing terminal stages of microvascular and macrovascular diabetic complications: blindness, end-stage chronic kidney disease, amputation of the lower extremities, myocardial infarction, cerebral stroke, worsens the patients prognosis and quality of life. There is ample evidence that blood pressure control in diabetic patients may be critical for improving long-term prognosis. This observation does not lose its relevance even with the emergence of new antidiabetic drugs with proven cardio- and nephroprotective effects. Modern clinical researchers and meta-analysis show the priority of combined antihypertensive therapy, which increases the efficacy of blood pressure correction and prophylaxis of long-term complications in patients with type 2 diabetes. In this article we want to pay attention to features of AH in patients with diabetes, to bi-directional pathogenic mechanisms, to discuss the new algorithms of the treatment and therapeutic needs of these patients. It is important to accent the understanding of the integrity and unity of pathogenic mechanisms which are needed in correction. Innovative antihyperglycemic therapy demonstrates the ability of blood pressure decrease. The synergy of effects let us successfully realize the strategy of multi-factor control and reduce a risk of micro- and macrovascular complications.</p></abstract><trans-abstract xml:lang="ru"><p>Артериальная гипертензия (АГ) является мощным и модифицируемым фактором риска развития макрососудистых и микрососудистых осложнений сахарного диабета (СД). Больные с АГ, страдающие СД, относятся к группе высокого и очень высокого риска развития сердечно-сосудистых осложнений и хронической болезни почек. Сочетание СД 2 типа и АГ резко увеличивает риск развития терминальных стадий микрососудистых и макрососудистых диабетических осложнений: слепоты, терминальной стадии хронической болезни почек, ампутации нижних конечностей, инфаркта миокарда, мозгового инсульта, ухудшает прогноз и качество жизни больных. Многочисленные данные свидетельствуют, что контроль за уровнем АД у больных СД может иметь решающее значение для улучшения долгосрочного прогноза. Это наблюдение не теряет своей актуальности даже при появлении новых противодиабетических препаратов, обладающих доказанными кардио- и нефропротективными эффектами. Современные клинические исследования и метаанализы продемонстрировали приоритет комбинированной антигипертензивной терапии, повышающей эффективность целевой коррекции АД и профилактики отдаленных осложнений у больных СД 2 типа. В данной статье мы хотим обратить внимание на особенности АГ у больных СД, на двунаправленность патогенетических механизмов этих заболеваний, обсудить новые алгоритмы лечения и терапевтические потребности таких пациентов. Важно подчеркнуть понимание целостности и единства патологических механизмов, коррекция которых крайне важна. Не удивительно, что инновационная патогенетически ориентированная сахароснижающая терапия логично демонстрирует способность снижать АД. Синергизм эффектов впервые позволяет успешно реализовывать стратегию многофакторного контроля у больных СД 2 типа и снижать риски микро- и макрососудистых осложнений.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>мартериальная гипертензия</kwd><kwd>сахарный диабет 2 типа</kwd><kwd>сердечно-сосудистые риски</kwd><kwd>гипотензивные препараты</kwd></kwd-group><kwd-group xml:lang="en"><kwd>arterial hypertension</kwd><kwd>type 2 diabetes mellitus</kwd><kwd>cardiovascular risk</kwd><kwd>antihypertensive medicine</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">2018 ESC/ESH Guidelines for the management of arterial hypertension. The Task Force for the management of arterial hypertension of the European Society of Cardiology (ESC) and the European Society of Hypertension (ESH). Eur Heart J. 2018;39(33):3021-104. 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