rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2013-9-5-532-541rpcardio-229Research ArticleINNOVATIVE CARDIOLOGYИННОВАЦИОННАЯ КАРДИОЛОГИЯLIPID METABOLISM CORRECTION BY ANTISENSE TECHNOLOGYKОРРЕКЦИЯ ЛИПИДНОГО ОБМЕНА С ИСПОЛЬЗОВАНИЕМ АНТИСЕНС-ТЕХНОЛОГИЙАфанасьеваО. И.AfanasievaO. I.

Доктор биологических наук, ведущий научный сотрудник лаборатории проблем атеросклероза института экспериментальной кардиологии

afanasieva@cardio.ruПокровскийС. Н.PokrovskyS. N.

Доктор биологических наук, профессор, руководитель лаборатории проблем атеросклероза института экспериментальной кардиологии

afanasieva@cardio.ruРоссийский кардиологический научно-производственный комплекс, МоскваРоссияRussian Cardiology Research and Production Complex, MoscowRussian Federation20132409201595532541Copyright © Afanasieva O.I., Pokrovsky S.N., 20152015Афанасьева О.И., Покровский С.Н.Afanasieva O.I., Pokrovsky S.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/229

Antisense oligonucleotides (ASO) technology in elaboration of drugs for lipid metabolism correction is discussed. The main ASO types and modes of its action on the target mRNA are analyzed. Advantages and disadvantages of different ASO are considered in the context of requirements for their therapeutic applications.Methods of ASO chemical modification; advantages and disadvantages of different ways of ASO delivery into the cells; developments state of ASO-drugs for therapy of lipid metabolism disturbances; data from clinical trials of these drugs are described.

Обсуждают использование антисмысловых олигонуклеотидов (АСО) для разработки препаратов для коррекции нарушений липидного обмена. Анализируют основные типы АСО и механизмы их действия на целевую мРНК. Рассматривают достоинства и недостатки различных АСО с точки зрения требований для их терапевтического применения.Описывают методы химической модификации олигонуклеотидов; преимущества и недостатки различных способов доставки АСО препаратов в клетки; состояние разработок крупнейшими фармакологическими компаниями АСО препаратов для коррекции нарушений липидного обмена; данные, полученные при проведении клинических испытаний таких препаратов.

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The authors declare that there are no conflicts of interest present.