rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2013-9-5-551-556rpcardio-232Research ArticlePOINT OF VIEWТОЧКА ЗРЕНИЯPRACTICAL APPLICATION OF DABIGATRAN ETEXILATE FOR STROKE PREVENTION IN PATIENTS WITH ATRIAL FIBRILLATIONПРАКТИЧЕСКОЕ ПРИМЕНЕНИЕ ДАБИГАТРАНА ЭТЕКСИЛАТА ДЛЯ ПРЕДОТВРАЩЕНИЯ ИНСУЛЬТА ПРИ ФИБРИЛЛЯЦИИ ПРЕДСЕРДИЙКосмачеваЕ. Д.KosmachevaE. D.

Доктор медицинских наук, профессор, заведующая кафедрой терапии №1 факультета повышения квалификации и последипломной переподготовки специалистов КубГМУ, главный кардиолог ЮФО и Краснодарского края

kanorskysg@mail.ruКанорскийС. Г.KanorskiyS. G.

Доктор медицинских наук, профессор, заведующий кафедрой терапии №2 факультета повышения квалификации и последипломной переподготовки специалистов

kanorskysg@mail.ruКастанаянА. А.KastanayanA. A.

Доктор медицинских наук, профессор, заведующий кафедрой внутренних болезней №2

kanorskysg@mail.ruХайлоН. В.HayloN. V.

Кандидат медицинских наук,  доцент кафедры внутренних болезней №1

kanorskysg@mail.ruГольтяпинД. Б.GoltyapinD. B.

Кандидат медицинских наук, научный руководитель клиники

kanorskysg@mail.ruЛипницкаяЕ. А.LipnitskayaE. A.

Ассистент кафедры госпитальной терапии

kanorskysg@mail.ruСтаценкоМ. Е.StatsenkoM. E.

Доктор медицинских наук, профессор, заведующий кафедрой внутренних болезней

kanorskysg@mail.ruКубанский государственный медицинский университет, КраснодарРоссияKuban State Medical University, KrasnodarRussian FederationРостовский государственный медицинский университет, Ростов-на-ДонуРоссияRostov State Medical University, Rostov-on-DonRussian FederationКлиника «Департамент Сердца, СтавропольРоссия“Heart Department” Clinic, StavropolRussian FederationАстраханская государственная медицинская академия, АстраханьРоссияAstrakhan State Medical Academy, AstrakhanRussian FederationВолгоградский государственный медицинский университет, ВолгоградРоссияVolgograd State Medical University, VolgogradRussian Federation20132409201595551556Copyright © Kosmacheva E.D., Kanorskiy S.G., Kastanayan A.A., Haylo N.V., Goltyapin D.B., Lipnitskaya E.A., Statsenko M.E., 20152015Космачева Е.Д., Канорский С.Г., Кастанаян А.А., Хайло Н.В., Гольтяпин Д.Б., Липницкая Е.А., Стаценко М.Е.Kosmacheva E.D., Kanorskiy S.G., Kastanayan A.A., Haylo N.V., Goltyapin D.B., Lipnitskaya E.A., Statsenko M.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/232

Disadvantages of vitamin K antagonist warfarin and the benefits of new anticoagulants, including dabigatran etexilate, in the stroke prevention in patients with atrial fibrillation are considered. Factors that influence the choice of dabigatran dose in different individuals are discussed. Dabigatran treatment in special conditions is considered: during stroke development; in electrical or pharmacological cardioversion; in invasive or surgical procedures; during bleeding. Possible organizational system of thromboembolic events prevention in patients with atrial fibrillation is presented.

Рассматриваются недостатки антагониста витамина К варфарина и преимущества новых антикоагулянтов, в частности дабигатрана этексилата, при проведении профилактики инсульта у больных с фибрилляцией предсердий. Обсуждаются факторы, влияющие на выбор дозы дабигатрана у отдельных пациентов. Рассматриваются вопросы лечения дабигатраном при развитии инсульта, при необходимости электрической или фармакологической кардиоверсии, инвазивных процедур или хи- рургических вмешательств, вопросы ведения больных с кровотечением на фоне приема дабигатрана. Представлена возможная система организации профилактики тромбоэмболических осложнений у пациентов с фибрилляцией предсердий.

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The authors declare that there are no conflicts of interest present.