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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2021-02-01</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-2392</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>PREVENTIVE CARDIOLOGY AND PUBLIC HEALTH</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ПРОФИЛАКТИЧЕСКАЯ КАРДИОЛОГИЯ И ОБЩЕСТВЕННОЕ ЗДОРОВЬЕ</subject></subj-group></article-categories><title-group><article-title>Basic Aspects of Seasonal Cardiovascular Mortality</article-title><trans-title-group xml:lang="ru"><trans-title>Основные аспекты сезонной сердечно-сосудистой смертности</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6104-0135</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Андреева</surname><given-names>Г. Ф.</given-names></name><name name-style="western" xml:lang="en"><surname>Andreeva</surname><given-names>G. F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Андреева Галия Фатиховна </p><p>Москва</p><p>eLibrary SPIN: 5401-4631</p></bio><bio xml:lang="en"><p>Galiya F. Andreeva</p><p>Moscow</p><p>eLibrary SPIN: 5401-4631</p></bio><email xlink:type="simple">gandreeva@gnicpm.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5195-8997</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Горбунов</surname><given-names>В. М.</given-names></name><name name-style="western" xml:lang="en"><surname>Gorbunov</surname><given-names>V. M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Горбунов Владимир Михайлович </p><p>Москва</p><p>eLibrary SPIN: 5111-1303</p></bio><bio xml:lang="en"><p>Vladimir M. Gorbunov</p><p>Moscow</p><p>eLibrary SPIN: 5111-1303</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр терапии и профилактической медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>02</day><month>03</month><year>2021</year></pub-date><volume>17</volume><issue>1</issue><fpage>92</fpage><lpage>98</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Andreeva G.F., Gorbunov V.M., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Андреева Г.Ф., Горбунов В.М.</copyright-holder><copyright-holder xml:lang="en">Andreeva G.F., Gorbunov V.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/2392">https://www.rpcardio.online/jour/article/view/2392</self-uri><abstract><p>The review demonstrates the main aspects of seasonal cardiovascular mortality. Climatic factors, including seasonal weather changes, have a significant impact on the biosphere. People are also characterized by the seasonal dynamics of the activity of many organs and systems, biochemical parameters, and mortality. Cardiovascular mortality is also characterized by seasonal fluctuations: in winter it is maximum, in summer it is minimal. The same patterns are characteristic of mortality from cardiovascular diseases (myocardial infarction, stroke, cardiac arrhythmias, etc.). The article presents the basic patterns of seasonal cardiovascular mortality in various climatic zones, the cardiovascular mortality of countries located in the equatorial and subequatorial climatic region. In addition, the mortality displacement phenomenon, the paradox of winter mortality. The main trends in changes in cardiovascular mortality over a long period of time are demonstrated. The paper discusses some of the mechanisms that underlie the dynamics of cardiovascular mortality during the year: seasonal fluctuations in the level of vitamin D, lipids in the blood plasma, changes in hemodynamic parameters, the effects of microbial and viral infections in the cold season, etc. In addition, data on seasonal the dynamics of risk factors for cardiovascular diseases is considered: an increase in body weight, a physical activity decrease, a change in the nutrition structure in the winter, the seasonal dynamics of depression, anxiety, hostility, the relationship of seasonal cardiovascular mortality with socio-economic, demographic and other factors. In conclusion, the main ways of development and prevention of seasonal CV cardiovascular mortality M, taking into account modern technologies at the international level, for state health departments, for specific patients, are demonstrated.</p></abstract><trans-abstract xml:lang="ru"><p>В обзоре рассмотрены основные аспекты сезонной сердечно-сосудистой смертности. Климатические факторы, в том числе, и сезонные изменения погоды оказывают значительное воздействие на биосферу, для человека тоже характерна сезонная динамика деятельности многих органов и систем, биохимических показателей, смертности. Сердечно-сосудистая смертность также характеризуется сезонными колебаниями: зимой она максимальна, летом – минимальна. Такие же закономерности характерны и для смертности от определенных сердечно-сосудистых заболеваний (инфаркта миокарда, инсульта, нарушений ритма сердца и др.). В статье представлены основные закономерности сезонной сердечно-сосудистой смертности в различных климатических зонах, особенности сердечно-сосудистой смертности в странах, находящихся в экваториальном и субэкваториальном климатическом регионе. Кроме того, освещен феномен смещения смертности, парадокс зимней смертности, продемонстрированы основные тенденции изменения сердечно-сосудистой смертности на протяжении длительного временного промежутка. В работе рассмотрены некоторые механизмы, которые лежат в основе динамики сердечно-сосудистой смертности в течение года: сезонные колебания уровня витамина D, липидов в плазме крови, изменения гемодинамических показателей, воздействие микробных и вирусных инфекций в холодное время года и др. Кроме того, приведены данные о сезонной динамике факторов риска сердечно-сосудистых заболеваний: увеличении массы тела, снижении физических нагрузок, изменение структуры питания в зимний период. Представлены результаты исследований, изучавших динамику депрессии, тревожности, враждебность в течение различных сезонов, рассмотрена взаимосвязь сезонной сердечно-сосудистой смертности с социально-экономическими, демографическими и др. факторами. В заключении продемонстрированы основные пути развития и профилактики сезонной сердечно-сосудистой смертности с учетом современных технологий на международном уровне, для департаментов здравоохранения государств, для конкретных пациентов.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>общая сезонная смертность</kwd><kwd>сердечно-сосудистая сезонная смертность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>general seasonal mortality</kwd><kwd>seasonal cardiovascular mortality</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Fowler T., Southgate R.J., Waite T., et al. 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