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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2021-02-08</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-2399</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>CURRENT QUESTIONS OF CLINICAL PHARMACOLOGY</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>АКТУАЛЬНЫЕ  ВОПРОСЫ  КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИ</subject></subj-group></article-categories><title-group><article-title>A Clinical Case: the Risk Factors of Acute Kidney Injury in a Cardiological Patient</article-title><trans-title-group xml:lang="ru"><trans-title>Клиническое наблюдение: факторы риска развития острого почечного повреждения у кардиологического пациента</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5168-8752</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сон</surname><given-names>Е. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Son</surname><given-names>E. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Сон Елена Алексеевна </p><p>Москва</p><p>eLibrary 1224-7753</p></bio><bio xml:lang="en"><p>Elena A. Son</p><p>Moscow</p><p>eLibrary 1224-7753</p></bio><email xlink:type="simple">sonalex1110@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-8880-1464</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кондратюк</surname><given-names>М. Р.</given-names></name><name name-style="western" xml:lang="en"><surname>Kondratyuk</surname><given-names>M. R.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Кондратюк Михаил Родионович </p><p>Москва</p></bio><bio xml:lang="en"><p>Mikhail R. Kondratiuk</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3733-4381</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фоминых</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fominykh</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фоминых Екатерина Викторовна </p><p>Москва</p></bio><bio xml:lang="en"><p>Ekaterina V. Fominykh</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2682-4417</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Фомин</surname><given-names>В. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Fomin</surname><given-names>V. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Фомин Виктор Викторович </p><p>Москва</p><p>eLibrary 8465-2747</p></bio><bio xml:lang="en"><p>Viktor V. Fomin</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Первый Московский государственный медицинский университет им. И. М. Сеченова Минздрава России (Сеченовский Университет)</institution><country>Россия</country></aff><aff xml:lang="en"><institution>I.M. Sechenov First Moscow State Medical University (Sechenov University)</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>03</day><month>03</month><year>2021</year></pub-date><volume>17</volume><issue>1</issue><fpage>140</fpage><lpage>145</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Son E.A., Kondratyuk M.R., Fominykh E.V., Fomin V.V., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Сон Е.А., Кондратюк М.Р., Фоминых Е.В., Фомин В.В.</copyright-holder><copyright-holder xml:lang="en">Son E.A., Kondratyuk M.R., Fominykh E.V., Fomin V.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/2399">https://www.rpcardio.online/jour/article/view/2399</self-uri><abstract><p>Recent epidemiological studies have demonstrated that the development of a potentially reversible moderate acute kidney injury is associated with worsening clinical outcomes and an increased risk of death. This is especially true for patients with plural comorbidities who require procedures with IV radiopaque agents. This paper presents a clinical case of an elderly patient who requires coronary angiography, and who has common clinical conditions such as hypertension, multifocal atherosclerosis with the development of renal artery disease and the presence of a history of acute cerebrovascular accident and myocardial infarction, and chronic heart failure as well. Particular attention is given to assessing the risk of developing contrast-induced acute kidney injury in patients with cardiovascular disease, as well as discussing current views on the possibility of prescribing drugs that affect the reninangiotensin system in cardiac patients with concomitant renal artery disease.</p></abstract><trans-abstract xml:lang="ru"><p>Данные эпидемиологических исследований последних лет убедительно демонстрируют, что развитие даже умеренного потенциально обратимого острого почечного повреждения ассоциировано с ухудшением клинических исходов и повышением риска смерти. Особенно это относится к пациентам с коморбидной патологией, которым необходимо проведение медицинских манипуляций с внутривенным введением рентгеноконтрастных препаратов. В работе приводится клиническое наблюдение достаточно типичного в практике терапевта пожилого пациента, нуждающегося в проведении ангиографии коронарных артерий, у которого имеются такие широко распространенные клинические состояния, как артериальная гипертензия, мультифокальный атеросклероз с развитием ишемической болезни почек и наличием в анамнезе острого нарушения мозгового кровообращения и инфаркта миокарда, а также хроническая сердечная недостаточность. Особое внимание было уделено оценке риска развития контраст-индуцированной нефропатии у пациентов с сердечно-сосудистой патологией, а также обсужден вопрос о современных взглядах на возможность назначения препаратов, влияющих на ренин-ангиотензиновую систему, у пациентов кардиологического профиля с сопутствующей ишемической болезнью почек.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>острое почечное повреждение</kwd><kwd>контраст-индуцированная нефропатия</kwd><kwd>стеноз почечных артерий</kwd><kwd>ишемическая болезнь почек</kwd><kwd>ингибиторы АПФ</kwd></kwd-group><kwd-group xml:lang="en"><kwd>acute kidney injury</kwd><kwd>contrast-induced nephropathy</kwd><kwd>renal artery stenosis</kwd><kwd>renal artery disease</kwd><kwd>angiotensin-converting enzyme inhibitor</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Lewington A.J., Cerda J., Mehta R.L. 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