rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2021-03-01rpcardio-2412Research ArticleCURRENT QUESTIONS OF CLINICAL PHARMACOLOGYАКТУАЛЬНЫЕ ВОПРОСЫ КЛИНИЧЕСКОЙ ФАРМАКОЛОГИИThe Importance of Antihypertensive and Lipid-Lowering Therapy in the Treatment of Patients with a New Coronavirus Infection COVID-19Значение антигипертензивной и гиполипидемической терапии в лечении пациентов, перенесших новую коронавирусную инфекцию COVID-19https://orcid.org/0000-0002-0758-5609ПодзолковВ. И.PodzolkovV. I.

Подзолков Валерий Иванович – eLibrary SPIN 8683-2155Москва

Valery I. Podzolkov - eLibrary SPIN 8683-2155

Moscow

ТарзимановаА. И.TarzimanovaA. I.

Тарзиманова Аида Ильгизовна – eLibrary SPIN 2685-4078

Москва

Aida I. Tarzimanova - eLibrary SPIN 2685-4078

Moscow

tarzimanova@mail.ruПервый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, RussiaRussian Federation202107052021172310314Copyright © Podzolkov V.I., Tarzimanova A.I., 20212021Подзолков В.И., Тарзиманова А.И.Podzolkov V.I., Tarzimanova A.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/2412

At the end of 2020, a new term “post-COVID-19 syndrome” appeared in the medical community. The prevalence of this syndrome reaches more than 30% among patients who have had COVID-19, and its duration can vary from 12 weeks to 6 months. One of the most severe consequences of COVID- 19 is the defeat of the cardiovascular system, which has a variety of mechanisms: dysregulation of the renin-angiotensin-aldosterone system; pathological systemic inflammatory response; direct action of the virus on the myocardium with the development of myocarditis; respiratory failure with hypoxia, leading to damage to cardiomyocytes; microvascular damage due to hypoperfusion, increased vascular permeability, angiospasm and the direct damaging effect of the virus on the endothelium of the coronary arteries; thrombotic complications due to the procoagulant and prothrombogenic effect of systemic inflammation. One of the most promising directions in the treatment and prevention of damage to the cardiovascular system in patients with hypertension who have undergone COVID-19 is the appointment of antihypertensive drugs that have the most pronounced organoprotective properties together with statins. The single pill combination of lisinopril, amlodipine and rosuvastatin is an effective drug that allows achieving not only adequate hypotensive and lipid-lowering effects, but also due to its pronounced organoprotective properties, to expect a reduction in cardiovascular risk and complications in patients who have suffered a new coronavirus infection caused by the SARS-CoV-2 virus.

В конце 2020 г. в медицинском сообществе появился новый термин «постковидный синдром» (post-COVID-19 syndrome). Распространенность данного синдрома достигает более 30% среди пациентов, перенесших COVID-19, а его продолжительность может варьировать от 12 нед до 6 мес. Одним из наиболее тяжелых последствий COVID-19 является поражение сердечно-сосудистой системы, имеющее разнообразные механизмы: дисрегуляция ренин-ангиотензин-альдостероновой системы; патологический системный воспалительный ответ; прямое действие вируса на миокард с развитием миокардита; дыхательная недостаточность с гипоксией, приводящие к повреждению кардиомиоцитов; мик- роваскулярное повреждение из-за гипоперфузии, повышенной сосудистой проницаемости, ангиоспазма и прямого повреждающего действия вируса на эндотелии коронарных артерии; тромботические осложнения вследствие прокоагулянтного и протромбогенного эффекта системного воспаления. Одним из наиболее перспективных направлений в лечении и профилактике повреждений сердечно-сосудистой системы у пациентов с артериальной гипертензией, перенесших COVID-19, является назначение антигипертензивных препаратов, обладающих наиболее выраженными органопротективными свойствами, совместно со статинами. Фиксированная комбинация лизиноприла, амлодипина и розу- вастатина представляет собой эффективный лекарственный препарат, который позволяет достигнуть не только адекватного гипотензивного и липидснижающего эффектов, но и, благодаря его выраженным органопротективным свойствам, ожидать уменьшения сердечно-сосудистого риска и осложнений у больных, перенесших новую коронавирусную инфекцию, вызванную вирусом SARS-CoV-2.

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The authors declare that there are no conflicts of interest present.