rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2021-04-08rpcardio-2435Research ArticlePOINT OF VIEWТОЧКА ЗРЕНИЯPost-COVID Syndrome and Tachycardia: Theoretical Base and Treatment ExperienceПостковидный синдром и тахикардия: теоретические основы и опыт леченияhttps://orcid.org/0000-0002-0758-5609ПодзолковВ. И.PodzolkovV. I.

Подзолков Валерий Иванович – eLibrary SPIN 8683-2155

Москва

Valery I. Podzolkov - eLibrary SPIN 8683-2155

Moscow

https://orcid.org/0000-0002-2699-1610БрагинаА. Е.BraginaA. E.

Брагина Анна Евгеньевна – eLibrary SPIN 3753-5539

Москва

Anna E. Bragina - eLibrary SPIN 3753-5539

Moscow

anna.bragina@mail.ruhttps://orcid.org/0000-0001-9536-8307ТарзимановаА. И.TarzimanovaA. I.

Тарзиманова Аида Ильгизовна – eLibrary SPIN 2685-4078

Москва

Aida I. Tarzimanova - eLibrary SPIN 2685-4078

Moscow

https://orcid.org/0000-0001-5730-7837ВасильеваЛ. В.Vasil'evaL. V.

Васильева Любовь Викторовна – eLibrary SPIN 9111-1333

Москва

Lubov V. Vasil'eva - eLibrary SPIN 9111-1333

Moscow

https://orcid.org/0000-0002-9386-3790БатраковаЕ. В.BatrakovaE. P.

Батракова Елена Павловна

Москва

Elena P. Batrakova

Moscow

https://orcid.org/0000-0002-2835-1852ЛобоваН. В.LobovaN. V.

Лобова Наталья Вячеславовна

Москва

Natalya V. Lobova

Moscow

https://orcid.org/0000-0002-4830-624XБыковаЕ. Е.BykovaE. E.

Быкова Екатерина Евгеньевна - eLibrary SPIN 8932-8731

Москва

Ekaterina E. Bykova - eLibrary SPIN 8932-8731

Moscow

https://orcid.org/0000-0003-3482-5791ХачуроеваМ. М.KhachuroevaM. M.

Хачуроева Марха Магомедовна

Москва

Markha M. Khachuroeva

Moscow

Первый Московский государственный медицинский университет им. И.М. Сеченова Минздрава России (Сеченовский Университет)РоссияI.M. Sechenov First Moscow State Medical University (Sechenov University)Russian Federation202106052021172256262Copyright © Podzolkov V.I., Bragina A.E., Tarzimanova A.I., Vasil'eva L.V., Batrakova E.P., Lobova N.V., Bykova E.E., Khachuroeva M.M., 20212021Подзолков В.И., Брагина А.Е., Тарзиманова А.И., Васильева Л.В., Батракова Е.В., Лобова Н.В., Быкова Е.Е., Хачуроева М.М.Podzolkov V.I., Bragina A.E., Tarzimanova A.I., Vasil'eva L.V., Batrakova E.P., Lobova N.V., Bykova E.E., Khachuroeva M.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/2435

The coronavirus pandemic showed not only an increase in levels of excess morbidity and mortality in the acute phase, but also persisting symptoms 4 weeks after the onset of the disease. A review of international studies on the prevalence and diversity of the manifestations of postcoid syndrome is presented. The data on such a manifestation of post-COVID syndrome as postural orthostatic tachycardia syndrome (POTS) are accumulating. Pathogenetic mechanisms, modern diagnostic criteria and research data on the prevalence of this syndrome are presented in the article. The Canadian Cardiovascular Society has proposed medications as a treatment for POTS, including the sinus node If channel inhibitor ivabradine. Data from several studies showing the effectiveness of this drug for POTS, including after suffering COVID-19, are presented in the article. Clinical data on the prevalence of tachycardia among patients admitted to the Sechenov University hospital are presented. About 18% of patients with hypertension and 21% of patients with normal blood pressure had a high heart rate. A clinical example of the use of ivabradine in a patient after a coronavirus infection is presented. Drug interactions and individual tolerance of ivabradine in patients after coronavirus infection are being discussed. The authors put forward the hypothesis about the further prospect of using ivabradine in the treatment of clinical manifestations of postcoid syndrome on the basis of literature data and their own experience.

Пандемия коронавирусной инфекции показала не только рост показателей избыточной заболеваемости и смертности в острую фазу, но также наличие сохраняющихся симптомов через 4 нед после начала проявления заболевания. Проведен обзор международных исследований, посвященных распространенности и разнообразия проявлений постковидного синдрома. Накапливаются данные о таком проявлении по- стковидного синдрома, как синдром постуральной ортостатической тахикардии (ПОТ). В статье представлены патогенетические механизмы, современные диагностические критерии и данные исследований о распространенности этого синдрома. Канадское кардиоваскулярное общество предложило в качестве лечения ПОТ-синдрома перечень медикаментозных средств, в числе которых - ингибитор If-каналов синусового узла ивабрадин. В статье приведены данные нескольких исследований, показавших эффективность данного препарата в отношении ПОТ-синдрома, в том числе, и после перенесенного COVID-19. Представлены клинические данные о распространенности тахикардии среди пациентов, госпитализированных в ковидный госпиталь, функционировавший на базе Университетской клинической больницы №4 (Сеченовский Университет), около 18% пациентов, имеющих артериальную гипертонию, и 21% пациентов с нормальными значениями АД имели высокую частоту сердечных сокращений. Приведен пример применения ивабрадина у пациентки, перенесшей коронавирусную инфекцию. Обсуждаются лекарственные взаимодействия и индивидуальная переносимость этого препарата у пациентов после коронавирусной инфекции. На основании данных литературы и собственного наблюдения авторами высказано предположение о дальнейшей перспективе применения ивабрадина в лечении клинических проявлений постковидного синдрома.

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The authors declare that there are no conflicts of interest present.