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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">rpcardio</journal-id><journal-title-group><journal-title xml:lang="en">Rational Pharmacotherapy in Cardiology</journal-title><trans-title-group xml:lang="ru"><trans-title>Рациональная Фармакотерапия в Кардиологии</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1819-6446</issn><issn pub-type="epub">2225-3653</issn><publisher><publisher-name>«SILICEA-POLIGRAF» LLC</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.20996/1819-6446-2021-06-02</article-id><article-id custom-type="elpub" pub-id-type="custom">rpcardio-2491</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL STUDIES</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ ИССЛЕДОВАНИЯ</subject></subj-group></article-categories><title-group><article-title>Changes in Cardiovascular Risk Factors in Residents of the Siberian Region (According to Epidemiological Studies)</article-title><trans-title-group xml:lang="ru"><trans-title>Динамика факторов сердечно-сосудистого риска у жителей Сибирского региона (по данным эпидемиологических исследований)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-2279-3307</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Артамонова</surname><given-names>Г. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Artamonova</surname><given-names>G. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Артамонова Галина Владимировна – eLibrary SPIN 3972-2791</p><p>Кемерово</p></bio><bio xml:lang="en"><p>Galina U Artamonova - eLibrary SPIN 3972-2791</p><p>Kemerovo</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-0545-2586</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Максимов</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Maksimov</surname><given-names>S. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Максимов Сергей Алексеевич – eLibrary SPIN 4362-1967</p><p>Москва</p></bio><bio xml:lang="en"><p>Sergey A. Maksimov - eLibrary SPIN 4362-1967</p><p>Moscow</p></bio><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6136-0518</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Цыганкова</surname><given-names>Д. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Tsygankova</surname><given-names>D. P.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Цыганкова Дарья Павловна – eLibrary SPIN 8064-3000</p><p>Кемерово</p></bio><bio xml:lang="en"><p>Daria P Tsygankova - eLibrary SPIN 8064-3000</p><p>Kemerovo</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-3023-6239</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Баздырев</surname><given-names>Е. Д.</given-names></name><name name-style="western" xml:lang="en"><surname>Bazdyrev</surname><given-names>E. D.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Баздырев Евгений Дмитриевич – eLibrary SPIN 4545-0791</p><p>Кемерово</p></bio><bio xml:lang="en"><p>Evgeny D. Bazdyrev - eLibrary SPIN 4545-0791</p><p>Kemerovo</p></bio><email xlink:type="simple">edb624@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-6911-6568</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Индукаева</surname><given-names>Е. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Indukaeva</surname><given-names>E. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Индукаева Елена Владимировна – eLibrary SPIN 9164-5554</p><p>Кемерово</p></bio><bio xml:lang="en"><p>Elena U Indukaeva - eLibrary SPIN 9164-5554</p><p>Kemerovo</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0657-4668</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мулерова</surname><given-names>Т. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Mulerova</surname><given-names>T. A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Мулерова Татьяна Александровна – eLibrary SPIN 1497-5896</p><p>Кемерово</p></bio><bio xml:lang="en"><p>Tatiana A. Mulerova - eLibrary SPIN 1497-5896</p><p>Kemerovo</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4497-0661</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шаповалова</surname><given-names>Э. Б.</given-names></name><name name-style="western" xml:lang="en"><surname>Shapovalova</surname><given-names>E. B.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Шаповалова Эвелина Борисовна – eLibrary SPIN 3339-4670</p><p>Кемерово</p></bio><bio xml:lang="en"><p>Evelina B. Shapovalova - eLibrary SPIN 3339-4670</p><p>Kemerovo</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-5521-4653</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Агиенко</surname><given-names>А. С.</given-names></name><name name-style="western" xml:lang="en"><surname>Agienko</surname><given-names>A. S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Агиенко Алена Сергеевна – eLibrary SPIN 7252-5646</p><p>Кемерово</p></bio><bio xml:lang="en"><p>Alena S. Agienko - eLibrary SPIN 7252-5646</p><p>Kemerovo</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-2778-6926</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нахратова</surname><given-names>О. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Nakhratova</surname><given-names>O. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Нахратова Ольга Владимировна – eLibrary SPIN 5397-6580</p><p>Кемерово</p></bio><bio xml:lang="en"><p>Olga U Nakhratova - eLibrary SPIN 5397-6580</p><p>Kemerovo</p></bio><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-4642-3610</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Барбараш</surname><given-names>О. Л.</given-names></name><name name-style="western" xml:lang="en"><surname>Barbarash</surname><given-names>O. L.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Барбараш Ольга Леонидовна – eLibrary SPIN 5373-7620</p><p>Кемерово</p></bio><bio xml:lang="en"><p>Olga L. Barbarash - eLibrary SPIN 5373-7620</p><p>Kemerovo</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний</institution><country>Россия</country></aff><aff xml:lang="en"><institution>Research Institute for Complex Issues of Cardiovascular Diseases</institution><country>Russian Federation</country></aff></aff-alternatives><aff-alternatives id="aff-2"><aff xml:lang="ru"><institution>Национальный медицинский исследовательский центр терапии и профилактической медицины</institution><country>Россия</country></aff><aff xml:lang="en"><institution>National Medical Research Center for Therapy and Preventive Medicine</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2021</year></pub-date><pub-date pub-type="epub"><day>11</day><month>07</month><year>2021</year></pub-date><volume>17</volume><issue>3</issue><fpage>362</fpage><lpage>368</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Artamonova G.V., Maksimov S.A., Tsygankova D.P., Bazdyrev E.D., Indukaeva E.V., Mulerova T.A., Shapovalova E.B., Agienko A.S., Nakhratova O.V., Barbarash O.L., 2021</copyright-statement><copyright-year>2021</copyright-year><copyright-holder xml:lang="ru">Артамонова Г.В., Максимов С.А., Цыганкова Д.П., Баздырев Е.Д., Индукаева Е.В., Мулерова Т.А., Шаповалова Э.Б., Агиенко А.С., Нахратова О.В., Барбараш О.Л.</copyright-holder><copyright-holder xml:lang="en">Artamonova G.V., Maksimov S.A., Tsygankova D.P., Bazdyrev E.D., Indukaeva E.V., Mulerova T.A., Shapovalova E.B., Agienko A.S., Nakhratova O.V., Barbarash O.L.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.rpcardio.online/jour/article/view/2491">https://www.rpcardio.online/jour/article/view/2491</self-uri><abstract><sec><title>Aim</title><p>Aim. To analyze prevalence of cardiovascular risk factors in the Kemerovo region based on the results of epidemiological studies (2013 and 2016).</p></sec><sec><title>Material and methods</title><p>Material and methods. The study was based on two large epidemiological studies of the Kemerovo region: on 2013, «The epidemiology of cardiovascular diseases and their risk factors in the Russian Federation» and on 2016, «The prospective study of urban and rural epidemiology: study of the influence of social factors on chronic non-infectious diseases in low, middle and high income countries». In the study we analyzed cardiovascular risk factors using identical questionnaires, functional, anthropometric, biochemical means and measured on identical scales. As a result, we analyzed the prevalence of smoking, diabetes mellitus, overweight and obesity, abdominal obesity, hypercholesterolemia and hypertriglyceridemia, high levels of low-density lipoprotein (LDL).</p></sec><sec><title>Results</title><p>Results. Univariate analysis indicates that in the sample of 2016, compared to the sample of 2013, the prevalence of smoking is statistically significantly lower, as well as the proportion of participants with high cholesterol levels, but not taking lipid-lowering drugs. In contrast, the prevalence of diabetes, hypercholesterolemia and hypertriglyceridemia is higher. In women, the frequency of abdominal obesity on 2016 is lower than on 2013: at 35-44 age group odds ratio (OR) =0.67 with 95% confidence interval (CI) 0.44-1.03, at 45-54 age group OR =0.47 with 95% CI 0.31-0.72, 55-65 age group OR =0.49 with 95% CI 0.30-0.79. A high incidence of diabetes, hypercholesterolemia and hypertriglyceridemia is characteristic mainly of older women (55-65 age group): accordingly, OR =1.96 with 95% CI 1.19-3.22, OR =1.42 with 95% CI 1,02-1.97, OR =1.51 at 95% CI 1.08-2.12. In the 45-54 age group of men, they smoked statistically significantly less often on 2016 compared to 2013, OR =0.59 with 95% CI 0.36-0.96. The prevalence of overweight and obesity in both samples is the same: for women, the OR for overweight in different age groups is within 0.74-0.87, for men - within 0.95-1.78; for obesity OR in women is from 0.70 to 0.79, in men - from 1.03 to 1.34.</p></sec><sec><title>Conclusion</title><p>Conclusion. A significant advantage of the study is the analysis of changes in prevalence in age and gender groups, which showed significant differences in the dynamics of men and women in different age categories for a number of risk factors. Analysis of the dynamics of the prevalence of cardiovascular risk factors makes it possible to assess the effectiveness of state and regional policies in the field of health protection and, first of all, "risk groups” that require closer attention, development and implementation of targeted health-saving technologies.</p></sec></abstract><trans-abstract xml:lang="ru"><sec><title>Цель</title><p>Цель. Изучить распространенность факторов сердечно-сосудистого риска в Кемеровской области по результатам эпидемиологических исследований (2013 и 2016 гг).</p></sec><sec><title>Материал и методы</title><p>Материал и методы. В основу исследования легли два крупных эпидемиологических исследования, проводившихся на территории Кемеровской области: в 2013 г - «Эпидемиология сердечно-сосудистых заболеваний и их факторов риска в Российской Федерации» и в 2016 г. - «Проспективное исследование городской и сельской эпидемиологии: изучение влияния социальных факторов на хронические неинфекционные заболевания в странах с низким, средним и высоким уровнем доходов». В работе анализировались факторы сердечнососудистого риска, данные, полученные в ходе обследований с помощью идентичных анкетных, функциональных, антропометрических, биохимических средств и измеренные в идентичных шкалах. В итоге анализировались распространенность курения, сахарного диабета (СД), избыточной массы тела и ожирения, абдоминального ожирения, гиперхолестеринемии и гипертриглицеридемии, высокого уровня липопротеидов низкой плотности (ЛПНП).</p></sec><sec><title>Результаты</title><p>Результаты. Однофакторный анализ свидетельствует о том, что в выборке 2016 г по сравнению с выборкой 2013 г. статистически значимо меньше была распространенность курения, и, напротив, была выше распространенность СД, гиперхолестеринемии и гипертриглицеридемии. У женщин частота абдоминального ожирения по сравнению с 2013 г в 2016 г меньше: в 35-44 лет отношение шансов (ОШ) 0,67 при 95% доверительном интервале (ДИ) 0,44-1,03, в 45-54 лет ОШ=0,47 при 95%ДИ 0,31-0,72, в 55-65 лет ОШ=0,49 при 95%ДИ 0,30-0,79. Высокая частота СД, гиперхолестеринемии и гипертриглицеридемии характерны преимущественно для женщин старшего возраста (55-65 лет): соответственно, ОШ = 1,96 при 95%ДИ 1,19-3,22, ОШ = 1,42 при 95%ДИ 1,02-1,97, ОШ = 1,51 при 95%ДИ 1,08-2,12. Мужчины в возрастной группе 45-54 лет в 2016 г по сравнению с 2013 г статистически значимо реже курили, ОШ=0,59 при 95%ДИ 0,36-0,96. Распространенность избыточной массы тела и ожирения в обеих выборках одинаковая: у женщин ОШ по избыточной массе тела в разных возрастных группах в пределах 0,74-0,87, у мужчин - в пределах 0,95-1,78; по ожирению ОШ у женщин составляют от 0,70 до 0,79, у мужчин - от 1,03 до 1,34.</p></sec><sec><title>Заключение</title><p>Заключение. Существенным достоинством проведенного исследования является анализ изменений распространенности факторов риска в половозрастных группах, который показал по некоторым из них существенные различия динамики у мужчин и женщин в разных возрастных категориях. Анализ динамики распространенности факторов сердечно-сосудистого риска позволяет оценить эффективность государственной и региональной политики в сфере охраны здоровья и, в первую очередь, групп риска, требующих более пристального внимания, разработки и внедрения адресных здоровье-сберегающих технологий.</p></sec></trans-abstract><kwd-group xml:lang="ru"><kwd>сердечно-сосудистый риск</kwd><kwd>эпидемиологические исследования</kwd><kwd>сахарный диабет</kwd><kwd>гиперхолестеринемия</kwd><kwd>гипертригли-церидемия</kwd><kwd>избыточная масса тела</kwd></kwd-group><kwd-group xml:lang="en"><kwd>cardiovascular risk</kwd><kwd>epidemiological studies</kwd><kwd>diabetes</kwd><kwd>hypercholesterolemia</kwd><kwd>hypertriglyceridemia</kwd><kwd>overweight</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Работа выполнена при поддержке компании Пфайзер (грант Р0915)</funding-statement><funding-statement xml:lang="en">The study was supported by Pfizer (grant P0915)</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Hudson SE, Feigenbaum MS, Patil N, et al. 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