rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2021-08-09rpcardio-2545Research ArticlePOINT OF VIEWТОЧКА ЗРЕНИЯAssessment of Arterial Stiffness Using the Cardio-Ankle Vascular Index – What We Know and What We Strive forОценка артериальной жесткости с помощью сердечно-лодыжечного сосудистого индекса – что мы знаем, и к чему стремимсяhttps://orcid.org/0000-0002-0963-4793СуминА. Н.SuminA. N.

Сумин Алексей Николаевич

eLibrary SPIN 5772-7038

Кемерово

Alexey N. Sumin

eLibrary SPIN 5772-7038

Kemerovo

an_sumin@mail.ruhttps://orcid.org/0000-0002-4108-164XЩегловаА. В.ShcheglovaA. V.

Щеглова Анна Викторовна

Кемерово

Anna V. Shcheglova 

Kemerovo

Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеванийРоссияResearch Institute for Complex Issues of Cardiovascular DiseasesRussian Federation202102092021174619627Copyright © Sumin A.N., Shcheglova A.V., 20212021Сумин А.Н., Щеглова А.В.Sumin A.N., Shcheglova A.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/2545

Currently, the importance of assessing arterial stiffness as an integral indicator of cardiovascular risk, an indicator of arteriosclerosis, and a predictor of cardiovascular events has been demonstrated. The traditional indicator of arterial stiffness-pulse wave velocity-depends on the level of blood pressure, which makes it difficult to use it for dynamic assessment. The proposed new arterial stiffness index-the cardio-ankle vascular index (CAVI), does not depend on the level of blood pressure and is more convenient in practical use. CAVI has been widely used in clinical medicine for the past 15 years as an index for assessing cardiovascular diseases and risk factors, which has allowed for the expansion and deepening of research on this topic. This review focuses primarily on recent publications and new opportunities for evaluating vascular function using CAVI. The review provides information on solving methodological problems in evaluating CAVI, highlights the relationship between CAVI and future cardiovascular events, and provides cross-sectional data on the Association of CAVI with the presence of cardiovascular diseases and their risk factors. The results of studies on the effect of drug therapy and measures to control risk factors for cardiovascular diseases on CAVI are presented. While it remains unclear how much changes in CAVI over time can affect the forecast, research is currently being conducted in this direction. The use of CAVI also opens up new perspectives in the assessment of cardiovascular interactions, the study of vascular function in vasculitis and vascular injuries, as well as in geriatric medicine (concepts of premature vascular aging and excess vascular aging).

В настоящее время продемонстрирована важность оценки артериальной жесткости как интегрального показателя сердечно-сосудистого риска, индикатора артериосклероза и предиктора сердечно-сосудистых событий. Традиционный показатель артериальной жесткости – скорость пульсовой волны – зависит от уровня артериального давления (АД), что затрудняет его использование для динамической оценки. Предложенный новый индекс артериальной жесткости – сердечно-лодыжечный сосудистый индекс (cardio-ankle vascular index, CAVI), не зависит от уровня АД и более удобен в практическом использовании. CAVI широко применялся в клинической медицине в течение последних 15 лет в качестве индекса для оценки сосудистой функции при сердечно-сосудистых заболеваниях (ССЗ) и факторов риска ССЗ, что позволило достичь расширения и углубления исследований по данной тематике. Настоящий обзор посвящен преимущественно публикациям последнего года и новым возможностям в оценке сосудистой функции с использованием CAVI. В обзоре представлены сведения о решении методологических проблем в оценке CAVI, подчеркивается связь между CAVI и будущими сердечно-сосудистыми событиями, приводятся данные перекрестных исследованиях об ассоциации CAVI с наличием ССЗ и их факторами риска. Приведены результаты исследований по влиянию на CAVI медикаментозной терапии и мероприятий по контролю факторов риска сердечно-сосудистых заболеваний. Пока остается неясным, насколько изменения CAVI с течением времени могут влиять на прогноз, сейчас проводятся исследования в данном направлении. Использование CAVI также открывает новые перспективы в оценке кардиоваскулярных взаимодействий, изучению сосудистой функции при системных заболеваниях соединительной ткани, а также в гериатрической медицине (концепции преждевременного сосудистого старения и сверхнормального старения сосудов).

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The authors declare that there are no conflicts of interest present.