rpcardioRational Pharmacotherapy in CardiologyРациональная Фармакотерапия в Кардиологии1819-64462225-3653«SILICEA-POLIGRAF» LLC10.20996/1819-6446-2014-10-3-312-316rpcardio-257Research ArticlePOINT OF VIEWТОЧКА ЗРЕНИЯRENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM AND REPLICATIVE CELLULAR SENESCENCE: THEIR INTERACTION DURING THE VASCULAR AGEINGРЕНИН-АНГИОТЕНЗИН-АЛЬДОСТЕРОНОВАЯ СИСТЕМА И РЕПЛИКАТИВНОЕ КЛЕТОЧНОЕ СТАРЕНИЕ: ИХ ВЗАИМОДЕЙСТВИЕ В ХОДЕ СТАРЕНИЯ СОСУДОВПыхтинаВ. С.PykhtinaV. S.

лаборант отдела комплексного снижения риска неинфекционных заболеваний

101990, Москва, Петроверигский пер., 10

Petroverigskiy per. 10, Moscow, 101990 Russia

vpykhtina@gnicpm.ruСтражескоИ. Д.StrazheskoI. D.

к.м.н., в.н.с. того же отдела

101990, Москва, Петроверигский пер., 10

Petroverigskiy per. 10, Moscow, 101990 Russia

АгальцовМ. В.AgaltsovM. V.

к.м.н., с.н.с. того же отдела

101990, Москва, Петроверигский пер., 10

Petroverigskiy per. 10, Moscow, 101990 Russia

ТкачеваО. Н.TkachevaO. N.

д.м.н., профессор, руководитель того же отдела

101990, Москва, Петроверигский пер., 10

Petroverigskiy per. 10, Moscow, 101990 Russia

Государственный научно-исследовательский центр профилактической медициныРоссияState Research Center for Preventive MedicineRussian Federation201425092015103312316Copyright © Pykhtina V.S., Strazhesko I.D., Agaltsov M.V., Tkacheva O.N., 20152015Пыхтина В.С., Стражеско И.Д., Агальцов М.В., Ткачева О.Н.Pykhtina V.S., Strazhesko I.D., Agaltsov M.V., Tkacheva O.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.rpcardio.online/jour/article/view/257

The problem of vascular aging is discussed. Special attention among the signs of vascular aging is paid to the activation of the renin-angiotensin-aldosterone system as a source of chronic inflammation and oxidative stress, as well as to its relation to replicative cellular senescence. Potential routes of exposure to these processes are also considered.

Рассматривается проблема сосудистого старения. Среди признаков сосудистого старения особое внимание уделяется активации ренин-ангиотензин-альдостероновой системы как источнику хронического воспаления и окислительного стресса и ее связи с репликативным клеточным старением. Также рассматриваются возможные пути воздействия на данные процессы.

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The authors declare that there are no conflicts of interest present.